Gab2 ELISA Kit for Mouse(Mus musculus) | EIAab.comGab2 ELISA Kit for Mouse(Mus musculus)

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Gab2 (Gene name),

GRB2-associated-binding protein 2 (Protein name ), GAB2_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Gab2;

Protein name:

GRB2-associated-binding protein 2;

Alternative:

Growth factor receptor bound protein 2-associated protein 2;GRB2-associated binder 2;PH domain-containing adaptor molecule p97;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with SHC1; may mediate interaction with receptors. Interacts with SYK. Interacts with PI-3 kinase. Interacts with GRB2 (via SH3 2 domain). Interacts with PTPN11. Interacts with TNFRSF11A (via cytoplasmic domain). Interacts (phosphorylated) with 14-3-3 family proteins SFN, YWHAB, YWHAE, YWHAG, YWHAH, YWHAQ and YWHAZ; prevents interaction with GRB2 and attenuates GAB2 signaling.

Function:

Adapter protein which acts downstream of several membrane receptors including cytokine, antigen, hormone, cell matrix and growth factor receptors to regulate multiple signaling pathways. Regulates osteoclast differentiation mediating the TNFRSF11A/RANK signaling. In allergic response, it plays a role in mast cells activation and degranulation through PI-3-kinase regulation. Also involved in the regulation of cell proliferation and hematopoiesis.

Subcellular Location:

Cytoplasm Cell membrane

Protein Attributes:

Sequence length:

665

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

650:

665:

TDVRQSSEPS | KGAKL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Mm.42033

SMR:

Q9Z1S8

String:

Q9Z1S8

Pfam:

PF00169

Uniprot:

Q9Z1S8

FOR

ELISA Kit for Mouse GRB2-associated-binding protein 2

Cat.:

E2740m

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MSDS:

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Packing:

96T

ELISA Kit for Mouse GRB2-associated-binding protein 2

Cat.:

E2740r

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96T

ELISA Kit for Mouse GRB2-associated-binding protein 2

Cat.:

E2740h

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96T

CLIA Kit for Mouse GRB2-associated-binding protein 2

Cat.:

U2740m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse GRB2-associated-binding protein 2

Cat.:

U2740r

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96T

CLIA Kit for Mouse GRB2-associated-binding protein 2

Cat.:

U2740h

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Packing:

96T

Polyclonal Antibody for Mouse GRB2-associated-binding protein 2

Cat.:

P2740Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse GRB2-associated-binding protein 2

Cat.:

P2740Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse GRB2-associated-binding protein 2

Cat.:

P2740Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse GRB2-associated-binding protein 2

Protein for Mouse GRB2-associated-binding protein 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Cloning of p97/Gab2, the major SHP2-binding protein in hematopoietic cells, reveals a novel pathway for cytokine-induced gene activation."
Gu H. , Pratt J.C. , Burakoff S.J. , Neel B.G.
Mol. Cell2:729-740(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 2-5; 81-91; 251-270; 277-293; 512-529; 630-635 AND 640-648;FUNCTION;PHOSPHORYLATION;INTERACTION WITH GRB2; PTPN11 AND SHC1;TISSUE SPECIFICITY
2.

"Gab-family adapter proteins act downstream of cytokine and growth factor receptors and T- and B-cell antigen receptors."
Nishida K. , Yoshida Y. , Itoh M. , Fukada T. , Ohtani T. , Shirogane T. , Atsumi T. , Takahashi-Tezuka M. , Ishihara K. , Hibi M. , Hirano T.
Blood93:1809-1816(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;TISSUE SPECIFICITY;PHOSPHORYLATION;DEPHOSPHORYLATION BY PTPN11;INTERACTION WITH GRB2; PTPN11 AND PI-3 KINASE
3.

"Essential role for Gab2 in the allergic response."
Gu H. , Saito K. , Klaman L.D. , Shen J. , Fleming T. , Wang Y. , Pratt J.C. , Lin G. , Lim B. , Kinet J.-P. , Neel B.G.
Nature412:186-190(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
4.

"The molecular scaffold Gab2 is a crucial component of RANK signaling and osteoclastogenesis."
Wada T. , Nakashima T. , Oliveira-dos-Santos A.J. , Gasser J. , Hara H. , Schett G. , Penninger J.M.
Nat. Med.11:394-399(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE;INTERACTION WITH TNFRSF11A;PHOSPHORYLATION AT TYR-441
5.

"Scaffolding adapter Grb2-associated binder 2 requires Syk to transmit signals from FcepsilonRI."
Yu M. , Lowell C.A. , Neel B.G. , Gu H.
J. Immunol.176:2421-2429(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SYK;LIPID-BINDING;MUTAGENESIS OF ARG-32
6.

"Abnormal hematopoiesis in Gab2 mutant mice."
Zhang Y. , Diaz-Flores E. , Li G. , Wang Z. , Kang Z. , Haviernikova E. , Rowe S. , Qu C.-K. , Tse W. , Shannon K.M. , Bunting K.D.
Blood110:116-124(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
7.

"Quantitative time-resolved phosphoproteomic analysis of mast cell signaling."
Cao L. , Yu K. , Banh C. , Nguyen V. , Ritz A. , Raphael B.J. , Kawakami Y. , Kawakami T. , Salomon A.R.
J. Immunol.179:5864-5876(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-261; THR-262; TYR-263 AND TYR-290;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Mast cell.
8.

"Phosphorylation-dependent binding of 14-3-3 terminates signalling by the Gab2 docking protein."
Brummer T. , Larance M. , Herrera Abreu M.T. , Lyons R.J. , Timpson P. , Emmerich C.H. , Fleuren E.D.G. , Lehrbach G.M. , Schramek D. , Guilhaus M. , James D.E. , Daly R.J.
EMBO J.27:2305-2316(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF ARG-32;PHOSPHORYLATION AT SER-211 AND THR-388

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