Gabbr1 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comGabbr1 ELISA Kit for Rat(Rattus norvegicus)

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Gabbr1 (Gene name),

Gamma-aminobutyric acid type B receptor subunit 1 (Protein name ), GABR1_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Gabbr1;

Protein name:

Gamma-aminobutyric acid type B receptor subunit 1(GABA-B receptor 1;GABA-B-R1;GABA-BR1;GABABR1;Gb1);

Alternative:

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Interacts with the leucine zipper of the C-terminal bZIP domain of ATF4 via its C-terminal region. Interacts with JAKMIP1.

Function:

Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.

Subcellular Location:

Cell membrane Multi-pass membrane protein Cell junction synapse postsynaptic cell membrane Multi-pass membrane protein Moreover coexpression of GABA-B-R1 and GABA-B-R2 appears to be a prerequisite for maturation and transport of GABA-B-R1 to the plasma membrane. Colocalizes with ATF4 in hippocampal neuron dendritic membranes.

Protein Attributes:

Sequence length:

991

Sequence:

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950:

991:

QLRSRRHPPT | PPDPSGGLPR | GPSEPPDRLS | CDGSRVHLLY | K

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Rn.30059

String:

Q9Z0U4

Pfam:

PF00003

SMR:

Q9Z0U4

KEGG:

rno:81657

Uniprot:

Q9Z0U4

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ELISA Kit for Rat GABA-B receptor 1

Cat.:

E2151h

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Manual:

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MSDS:

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Packing:

96T

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ELISA Kit for Rat GABA-B receptor 1

Cat.:

E2151r

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MSDS:

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Packing:

96T

ELISA Kit for Rat GABA-B receptor 1

Cat.:

E2151m

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MSDS:

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Packing:

96T

CLIA Kit for Rat GABA-B receptor 1

Cat.:

U2151m

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MSDS:

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Packing:

96T

CLIA Kit for Rat GABA-B receptor 1

Cat.:

U2151r

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Rat GABA-B receptor 1

Cat.:

U2151h

Price:

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MSDS:

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Packing:

96T

Polyclonal Antibody for Rat GABA-B receptor 1

Cat.:

P2151Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat GABA-B receptor 1

Cat.:

P2151Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Rat GABA-B receptor 1

Cat.:

P2151Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Rat GABA-B receptor 1

Protein for Rat GABA-B receptor 1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors."
Kaupmann K. , Huggel K. , Heid J. , Flor P.J. , Bischoff S. , Mickel S.J. , McMaster G. , Angst C. , Bittiger H. , Froestl W. , Bettler B.
Nature386:239-246(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1A AND 1B);FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
strain: RICO.
tissue: Brain cortex.
tissue: Cerebellum.
2.

"Cloning and tissue distribution of novel splice variants of the rat GABAB receptor."
Isomoto S. , Kaibara M. , Sakurai-Yamashita Y. , Nagayama Y. , Uezono Y. , Yano K. , Taniyama K.
Biochem. Biophys. Res. Commun.253:10-15(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1C AND 1D);TISSUE SPECIFICITY
tissue: Cerebellum.
3.

"Alternative splicing generates a novel isoform of the rat metabotropic GABA(B)R1 receptor."
Pfaff T. , Malitschek B. , Kaupmann K. , Prezeau L. , Pin J.-P. , Bettler B. , Karschin A.
Eur. J. Neurosci.11:2874-2882(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];ALTERNATIVE SPLICING (ISOFORM 1E)
strain: Wistar.
tissue: Hippocampus.
4.

"Identification of a GABAB receptor subunit, gb2, required for functional GABAB receptor activity."
Ng G.Y.K. , Clark J. , Coulombe N. , Ethier N. , Hebert T.E. , Sullivan R. , Kargman S. , Chateauneuf A. , Tsukamoto N. , McDonald T. , Whiting P. , Mezey E. , Johnson M.P. , Liu Q. , Kolakowski L.F. Jr. , Evans J.F. , Bonner T.I. , O'Neill G.P.
J. Biol. Chem.274:7607-7610(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1A);INTERACTION WITH GABBR2
tissue: Brain.
5.

"Synthesis of the nanomolar photoaffinity GABA(B) receptor ligand CGP 71872 reveals diversity in the tissue distribution of GABA(B) receptor forms."
Belley M. , Sullivan R. , Reeves A. , Evans J.F. , O'Neill G.P. , Ng G.Y.K.
Bioorg. Med. Chem.7:2697-2704(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
6.

"Role of heteromer formation in GABAB receptor function."
Kuner R. , Koehr G. , Gruenewald S. , Eisenhardt G. , Bach A. , Kornau H.-C.
Science283:74-77(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GABBR2
7.

"The metabotropic GABAB receptor directly interacts with the activating transcription factor 4."
Nehring R.B. , Horikawa H.P.M. , El Far O. , Kneussel M. , Brandstatter J.H. , Stamm S. , Wischmeyer E. , Betz H. , Karschin A.
J. Biol. Chem.275:35185-35191(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ATF4;SUBCELLULAR LOCATION
8.

"Ca(2+) requirement for high-affinity gamma-aminobutyric acid (GABA) binding at GABA(B) receptors: involvement of serine 269 of the GABA(B)R1 subunit."
Galvez T. , Urwyler S. , Prezeau L. , Mosbacher J. , Joly C. , Malitschek B. , Heid J. , Brabet I. , Froestl W. , Bettler B. , Kaupmann K. , Pin J.-P.
Mol. Pharmacol.57:419-426(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF SER-247; SER-268 AND SER-269
9.

"Marlin-1, a novel RNA-binding protein associates with GABA receptors."
Couve A. , Restituito S. , Brandon J.M. , Charles K.J. , Bawagan H. , Freeman K.B. , Pangalos M.N. , Calver A.R. , Moss S.J.
J. Biol. Chem.279:13934-13943(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH JAKMIP1
10.

"Structural analysis of the complement control protein (CCP) modules of GABA(B) receptor 1a: only one of the two CCP modules is compactly folded."
Blein S. , Ginham R. , Uhrin D. , Smith B.O. , Soares D.C. , Veltel S. , McIlhinney R.A. , White J.H. , Barlow P.N.
J. Biol. Chem.279:48292-48306(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 96-159;DISULFIDE BONDS

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