GABBR2 ELISA Kit for Human(Homo sapiens) | EIAab.comGABBR2 ELISA Kit for Human(Homo sapiens) | EIAab.com

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GABBR2 (Gene name),

Gamma-aminobutyric acid type B receptor subunit 2 (Protein name ), GABR2_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

GABBR2(GPR51;GPRC3B);

Protein name:

Gamma-aminobutyric acid type B receptor subunit 2(GABA-B receptor 2;GABA-B-R2;GABA-BR2;GABABR2;Gb2);

Alternative:

HG20;G-protein coupled receptor 51;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Interacts with ATF4 via its C-terminal region.

Function:

Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.

Subcellular Location:

Cell membrane Multi-pass membrane protein Cell junction synapse postsynaptic cell membrane Multi-pass membrane protein Moreover coexpression of GABA-B-R1 and GABA-B-R2 appears to be a prerequisite for maturation and transport of GABA-B-R1 to the plasma membrane.

Protein Attributes:

Sequence length:

941

Sequence:

50:

MASPRSSGQP | GPPPPPPPPP | ARLLLLLLLP | LLLPLAPGAW | GWARGAPRPP |

100:

PSSPPLSIMG | LMPLTKEVAK | GSIGRGVLPA | VELAIEQIRN | ESLLRPYFLD |

150:

LRLYDTECDN | AKGLKAFYDA | IKYGPNHLMV | FGGVCPSVTS | IIAESLQGWN |

200:

LVQLSFAATT | PVLADKKKYP | YFFRTVPSDN | AVNPAILKLL | KHYQWKRVGT |

250:

LTQDVQRFSE | VRNDLTGVLY | GEDIEISDTE | SFSNDPCTSV | KKLKGNDVRI |

300:

ILGQFDQNMA | AKVFCCAYEE | NMYGSKYQWI | IPGWYEPSWW | EQVHTEANSS |

350:

RCLRKNLLAA | MEGYIGVDFE | PLSSKQIKTI | SGKTPQQYER | EYNNKRSGVG |

400:

PSKFHGYAYD | GIWVIAKTLQ | RAMETLHASS | RHQRIQDFNY | TDHTLGRIIL |

450:

NAMNETNFFG | VTGQVVFRNG | ERMGTIKFTQ | FQDSREVKVG | EYNAVADTLE |

500:

IINDTIRFQG | SEPPKDKTII | LEQLRKISLP | LYSILSALTI | LGMIMASAFL |

550:

FFNIKNRNQK | LIKMSSPYMN | NLIILGGMLS | YASIFLFGLD | GSFVSEKTFE |

600:

TLCTVRTWIL | TVGYTTAFGA | MFAKTWRVHA | IFKNVKMKKK | IIKDQKLLVI |

650:

VGGMLLIDLC | ILICWQAVDP | LRRTVEKYSM | EPDPAGRDIS | IRPLLEHCEN |

700:

THMTIWLGIV | YAYKGLLMLF | GCFLAWETRN | VSIPALNDSK | YIGMSVYNVG |

750:

IMCIIGAAVS | FLTRDQPNVQ | FCIVALVIIF | CSTITLCLVF | VPKLITLRTN |

800:

PDAATQNRRF | QFTQNQKKED | SKTSTSVTSV | NQASTSRLEG | LQSENHRLRM |

850:

KITELDKDLE | EVTMQLQDTP | EKTTYIKQNH | YQELNDILNL | GNFTESTDGG |

900:

KAILKNHLDQ | NPQLQWNTTE | PSRTCKDPIE | DINSPEHIQR | RLSLQLPILH |

941:

HAYLPSIGGV | DASCVSPCVS | PTASPRHRHV | PPSFRVMVSG | L

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

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Related Databases

SMR:

STRING:

9606.ENSP00000259455

String:

MIM:

Pfam:

UniGene:

KEGG:

Uniprot:

FOR

ELISA Kit for Human GABA-B receptor 2

ELISA Kit for Human GABA-B receptor 2

ELISA Kit for Human GABA-B receptor 2

CLIA Kit for Human GABA-B receptor 2

CLIA Kit for Human GABA-B receptor 2

CLIA Kit for Human GABA-B receptor 2

Polyclonal Antibody for Human GABA-B receptor 2

Polyclonal Antibody for Human GABA-B receptor 2

Polyclonal Antibody for Human GABA-B receptor 2

Monoclonal Antibody for Human GABA-B receptor 2

Monoclonal Antibody for Human GABA-B receptor 2

Monoclonal Antibody for Human GABA-B receptor 2

Protein for Human GABA-B receptor 2

Protein for Human GABA-B receptor 2

Protein for Human GABA-B receptor 2

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Heterodimerization is required for the formation of a functional GABA(B) receptor."
White J.H. , Wise A. , Main M.J. , Green A. , Fraser N.J. , Disney G.H. , Barnes A.A. , Emson P. , Foord S.M. , Marshall F.H.
Nature396:679-682(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBUNIT;INTERACTION WITH GABBR1;SUBCELLULAR LOCATION
tissue: Cerebellum.
2.

"Cloning of a novel G-protein-coupled receptor GPR 51 resembling GABAB receptors expressed predominantly in nervous tissues and mapped proximal to the hereditary sensory neuropathy type 1 locus on chromosome 9."
Ng G.Y.K. , McDonald T. , Bonnert T. , Rigby M. , Heavens R. , Whiting P. , Chateauneuf A. , Coulombe N. , Kargman S. , Caskey T. , Evans J.F. , O'Neill G.P. , Liu Q.
Genomics56:288-295(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
tissue: Fetal brain.
3.

"Molecular identification of the human GABABR2: cell surface expression and coupling to adenylyl cyclase in the absence of GABABR1."
Martin S.C. , Russek S.J. , Farb D.H.
Mol. Cell. Neurosci.13:180-191(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION;SUBCELLULAR LOCATION;TISSUE SPECIFICITY;VARIANTS PHE-628 AND ALA-869
tissue: Brain.
4.

"Distribution of the GABA(B) receptor subunit gb2 in rat CNS."
Clark J.A. , Mezey E. , Lam A.S. , Bonner T.I.
Brain Res.860:41-52(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
tissue: Brain.
5.

"Cloning and characterization of a novel human GABA-B receptor subtype with high affinity for GABA and low affinity for baclofen."
Liu M. , Parker R. , McCrea K. , Watson J. , Baker E. , Sutherland G. , Herzog H.
Submitted (1998-11) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
6.

Borowsky B. , Laz T. , Gerald C.
Submitted (1999-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Hippocampus.
7.

"DNA sequence and analysis of human chromosome 9."
Humphray S.J. , Oliver K. , Hunt A.R. , Plumb R.W. , Loveland J.E. , Howe K.L. , Andrews T.D. , Searle S. , Hunt S.E. , Scott C.E. , Jones M.C. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Ashwell R.I.S. , Babbage A.K. , Babbage S. , Bagguley C.L. , more...
Nature429:369-374(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 14-941
tissue: Hippocampus.
9.

"Identification of a GABAB receptor subunit, gb2, required for functional GABAB receptor activity."
Ng G.Y.K. , Clark J. , Coulombe N. , Ethier N. , Hebert T.E. , Sullivan R. , Kargman S. , Chateauneuf A. , Tsukamoto N. , McDonald T. , Whiting P. , Mezey E. , Johnson M.P. , Liu Q. , Kolakowski L.F. Jr. , Evans J.F. , Bonner T.I. , O'Neill G.P.
J. Biol. Chem.274:7607-7610(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GABBR1
10.

"Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor."
Sullivan R. , Chateauneuf A. , Coulombe N. , Kolakowski L.F. Jr. , Johnson M.P. , Hebert T.E. , Ethier N. , Belley M. , Metters K. , Abramovitz M. , O'Neill G.P. , Ng G.Y.K.
J. Pharmacol. Exp. Ther.293:460-467(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GABBR1
11.

"Subcellular distribution of GABA(B) receptor homo- and hetero-dimers."
Villemure J.F. , Adam L. , Bevan N.J. , Gearing K. , Chenier S. , Bouvier M.
Biochem. J.388:47-55(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT;SUBCELLULAR LOCATION
12.

"Direct detection of the interaction between recombinant soluble extracellular regions in the heterodimeric metabotropic gamma-aminobutyric acid receptor."
Nomura R. , Suzuki Y. , Kakizuka A. , Jingami H.
J. Biol. Chem.283:4665-4673(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT;INTERACTION WITH GABBR1
13.

"Structure and functional interaction of the extracellular domain of human GABA(B) receptor GBR2."
Geng Y. , Xiong D. , Mosyak L. , Malito D.L. , Kniazeff J. , Chen Y. , Burmakina S. , Quick M. , Bush M. , Javitch J.A. , Pin J.P. , Fan Q.R.
Nat. Neurosci.15:970-978(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.38 ANGSTROMS) OF 42-466;PARTIAL PROTEIN SEQUENCE;FUNCTION;INTERACTION WITH GABBR1;MUTAGENESIS OF TYR-118;GLYCOSYLATION AT ASN-90; ASN-389; ASN-404 AND ASN-453;DISULFIDE BONDS
14.

"Structural mechanism of ligand activation in human GABA(B) receptor."
Geng Y. , Bush M. , Mosyak L. , Wang F. , Fan Q.R.
Nature504:254-259(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.9 ANGSTROMS) OF 42-466 IN COMPLEXES WITH GABBR1; AGONISTS AND ANTAGONISTS;FUNCTION;SUBUNIT;GLYCOSYLATION AT ASN-404;DISULFIDE BOND

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