Gabbr2 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comGabbr2 ELISA Kit for Rat(Rattus norvegicus)

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Gabbr2 (Gene name),

Gamma-aminobutyric acid type B receptor subunit 2 (Protein name ), GABR2_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Gabbr2(Gpr51);

Protein name:

Gamma-aminobutyric acid type B receptor subunit 2(GABA-B receptor 2;GABA-B-R2;GABA-BR2;GABABR2;Gb2);

Alternative:

G-protein coupled receptor 51;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Heterodimer of GABA-B-R1 and GABA-B-R2. Neither of which is effective on its own and homodimeric assembly does not seem to happen. Interacts with ATF4 via its C-terminal region.

Function:

Receptor for GABA. The activity of this receptor is mediated by G-proteins that inhibit adenylyl cyclase activity, stimulates phospholipase A2, activates potassium channels, inactivates voltage-dependent calcium-channels and modulates inositol phospholipids hydrolysis. Plays a critical role in the fine-tuning of inhibitory synaptic transmission. Pre-synaptic GABA-B-R inhibit neurotransmitter release by down-regulating high-voltage activated calcium channels, whereas postsynaptic GABA-B-R decrease neuronal excitability by activating a prominent inwardly rectifying potassium (Kir) conductance that underlies the late inhibitory postsynaptic potentials. Not only implicated in synaptic inhibition but also in hippocampal long-term potentiation, slow wave sleep, muscle relaxation and antinociception.

Subcellular Location:

Cell membrane Multi-pass membrane protein Cell junction synapse postsynaptic cell membrane Multi-pass membrane protein Moreover coexpression of GABA-B-R1 and GABA-B-R2 appears to be a prerequisite for maturation and transport of GABA-B-R1 to the plasma membrane.

Protein Attributes:

Sequence length:

940

Sequence:

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940:

AYLPSIGGVD | ASCVSPCVSP | TASPRHRHVP | PSFRVMVSGL |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

rno:83633

UniGene:

Rn.162814

Pfam:

PF00003

String:

O88871

Uniprot:

O88871

FOR

ELISA Kit for Rat GABA-B receptor 2

CLIA Kit for Rat GABA-B receptor 2

Polyclonal Antibody for Rat GABA-B receptor 2

Monoclonal Antibody for Rat GABA-B receptor 2

Protein for Rat GABA-B receptor 2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2."
Jones K.A. , Borowsky B. , Tamm J.A. , Craig D.A. , Durkin M.M. , Dai M. , Yao W.-J. , Johnson M. , Gunwaldsen C.A. , Huang L.-Y. , Tang C. , Shen Q. , Salon J.A. , Morse K. , Laz T. , Smith K.E. , Nagarathnam D. , Noble S.A. , more...
Nature396:674-679(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Hypothalamus.
2.

"GABA-B receptor subtypes assemble into functional heteromeric complexes."
Kaupmann K. , Malitschek B. , Schuler V. , Heid J. , Froestl W. , Beck P. , Mosbacher J. , Bischoff S. , Kulik A. , Shigemoto R. , Karschin A. , Bettler B.
Nature396:683-687(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];FUNCTION;INTERACTION WITH GABBR1;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
tissue: Brain cortex.
tissue: Cerebellum.
3.

"Distribution of the GABA(B) receptor subunit gb2 in rat CNS."
Clark J.A. , Mezey E. , Lam A.S. , Bonner T.I.
Brain Res.860:41-52(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY
tissue: Brain cortex.
4.

Borowsky B. , Laz T. , Gerald C.
Submitted (1999-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Hypothalamus.
5.

"Role of heteromer formation in GABAB receptor function."
Kuner R. , Koehr G. , Gruenewald S. , Eisenhardt G. , Bach A. , Kornau H.-C.
Science283:74-77(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH GABBR1;VARIANTS PRO-19 INS AND TYR-337
tissue: Hippocampus.
6.

"The metabotropic GABAB receptor directly interacts with the activating transcription factor 4."
Nehring R.B. , Horikawa H.P.M. , El Far O. , Kneussel M. , Brandstatter J.H. , Stamm S. , Wischmeyer E. , Betz H. , Karschin A.
J. Biol. Chem.275:35185-35191(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ATF4

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