Language:
  
[Sign in] [Register]   

EIAab logo

Index > Protein center > Gan(Gene name) > Mouse
  • Add your favorite
  • Gan (Gene name),
  • Gigaxonin (Protein name ),  GAN_MOUSE from NCBI database.
  • top
  • Come back to page head.
  • |
  • General Annotation
  • |
  • Antigen Annotation
  • |
  • 3D
  • |
  • Predicted Eptitope
  • |
  • Vaild Sequence
  • |
  • Related Databases
  • |
  • Feedback
  • Gene name:
    Gan;
    Protein name:
    Gigaxonin;
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with TBCB. Interacts with CUL3. Part of a complex that contains CUL3, RBX1 and GAN. Interacts (via BTB domain) with UBA1 (By similarity). Interacts (via Kelch domains) with MAP1B (via C-terminus) and MAP1S (via C-terminus).
    Function:
    Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. Substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of TBCB (By similarity). Controls degradation of MAP1B and MAP1S, and is critical for neuronal maintenance and survival.
    Subcellular Location:
    Cytoplasm cytoskeleton
    Protein Attributes:
    Sequence length:
    597
    Sequence:
    50:
    MAEGSAVSDP | QHAARLLRAL | SSFREEARFC | DAHLVLDGEE | IPVQKNILAA | 
    100:
    ASPYIRTKLN | YNPPKDDGST | YKIELEGISV | MVMREILDYI | FSGQIRLNED | 
    150:
    TIQDVVQAAD | LLLLTDLKTL | CCEFLEGCIA | AENCIGIRDF | ALHYCLHHVH | 
    200:
    YLATEYLETH | FRDVSSTEEF | LELSPQKLKE | VISLEKLNVG | NERYVFEAVI | 
    250:
    RWIAHDVEMR | KVHMKDVMSA | LWVSGLDSSY | LREQMLNEPL | VREIVKECSN | 
    300:
    IPLSQPQQGE | AMLASFKPRG | YSECIVTIGG | EERVSRKPTA | AMRCMCPLYD | 
    350:
    PNRQLWIELA | PLSMPRINHG | VLSAEGFLFV | LGGQDENKQT | LSSGEKYDPD | 
    400:
    ANTWTALPPM | HEARHNFGIV | EIDGMLYILG | GEDGDRELIS | MECYDIYSKT | 
    450:
    WTKQPDLTMV | RKIGCYAAMK | KKIYAMGGGS | YGKLFESVEC | YDPRTQQWTA | 
    500:
    ICPLKERRFG | AVACGVAMEL | YVFGGVRSRE | DIQGSEMVTC | KSEFYHDEFK | 
    550:
    RWIYLNDQNL | CIPASSSFVY | GAVPIGASIY | VIGDLDTGTN | YDYVREFKRS | 
    597:
    TGTWHHTKPL | LPSDLRRTGC | AALRIANCKL | FRLQLQQGLF | RIRVHSP
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    String:
    SMR:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Gigaxonin
    ELISA Kit for Mouse Gigaxonin
    CLIA Kit for Mouse Gigaxonin
    CLIA Kit for Mouse Gigaxonin
    Polyclonal Antibody for Mouse Gigaxonin
    Polyclonal Antibody for Mouse Gigaxonin
    Monoclonal Antibody for Mouse Gigaxonin
    Monoclonal Antibody for Mouse Gigaxonin
    Protein for Mouse Gigaxonin
    Protein for Mouse Gigaxonin

    R&D Technical Data
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Precision
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Recovery
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Linearity
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-597
      strain: C57BL/6J.
      tissue: Spinal cord.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-597
    4. 4.
      "Microtubule-associated protein 1B: a neuronal binding partner for gigaxonin."
      Ding J. , Liu J.-J. , Kowal A.S. , Nardine T. , Bhattacharya P. , Lee A. , Yang Y.
      J. Cell Biol.158:427-433(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MAP1B;SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    5. 5.
      "Gigaxonin-controlled degradation of MAP1B light chain is critical to neuronal survival."
      Allen E. , Ding J. , Wang W. , Pramanik S. , Chou J. , Yau V. , Yang Y.
      Nature438:224-228(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    6. 6.
      "Gene targeting of GAN in mouse causes a toxic accumulation of microtubule-associated protein 8 and impaired retrograde axonal transport."
      Ding J. , Allen E. , Wang W. , Valle A. , Wu C. , Nardine T. , Cui B. , Yi J. , Taylor A. , Jeon N.L. , Chu S. , So Y. , Vogel H. , Tolwani R. , Mobley W. , Yang Y.
      Hum. Mol. Genet.15:1451-1463(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH MAP1S;DISRUPTION PHENOTYPE
    7. 7.
      "Modest loss of peripheral axons, muscle atrophy and formation of brain inclusions in mice with targeted deletion of gigaxonin exon 1."
      Dequen F. , Bomont P. , Gowing G. , Cleveland D.W. , Julien J.-P.
      J. Neurochem.107:253-264(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISRUPTION PHENOTYPE
    Product Feedback Wall
    Hot Genes
    Atf2 ASPRO ACE ALCAM C19orf80 Trap1a Gdf5
    Top Searches
    Ubiquitin-protein ligase metalloproteinase Ubiquitin ELISA Alpha Tumor necrosis Asprosin TRAP1A
    Why choose EIAAB
    Our products have been quoted by many publications in famous journals such as Cell; Cell Metabolism; Hepatology; Biomaterials.more
    Further Information
    About us Protein center Bank account Distributors Terms & Conditions Career eiaab.com.cn

    Copyright & copy www.eiaab.com2006-2016 All Rights Reserved    EIAab         Email:eiaab@eiaab.com

    鄂ICP备10015095号-1

    鄂公网安备 42018502005535号

    Twitter