Protein name:
Gigaxonin ;
Alternative:
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Interacts with TBCB. Interacts with CUL3. Part of a complex that contains CUL3, RBX1 and GAN. Interacts (via BTB domain) with UBA1 (By similarity). Interacts (via Kelch domains) with MAP1B (via C-terminus) and MAP1S (via C-terminus).
Function:
Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. Substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of TBCB (By similarity). Controls degradation of MAP1B and MAP1S, and is critical for neuronal maintenance and survival.
Subcellular Location:
Cytoplasm
cytoskeleton
Protein Attributes:
50:
MAEGSAVSDP | QHAARLLRAL | SSFREEARFC | DAHLVLDGEE | IPVQKNILAA |
100:
ASPYIRTKLN | YNPPKDDGST | YKIELEGISV | MVMREILDYI | FSGQIRLNED |
150:
TIQDVVQAAD | LLLLTDLKTL | CCEFLEGCIA | AENCIGIRDF | ALHYCLHHVH |
200:
YLATEYLETH | FRDVSSTEEF | LELSPQKLKE | VISLEKLNVG | NERYVFEAVI |
250:
RWIAHDVEMR | KVHMKDVMSA | LWVSGLDSSY | LREQMLNEPL | VREIVKECSN |
300:
IPLSQPQQGE | AMLASFKPRG | YSECIVTIGG | EERVSRKPTA | AMRCMCPLYD |
350:
PNRQLWIELA | PLSMPRINHG | VLSAEGFLFV | LGGQDENKQT | LSSGEKYDPD |
400:
ANTWTALPPM | HEARHNFGIV | EIDGMLYILG | GEDGDRELIS | MECYDIYSKT |
450:
WTKQPDLTMV | RKIGCYAAMK | KKIYAMGGGS | YGKLFESVEC | YDPRTQQWTA |
500:
ICPLKERRFG | AVACGVAMEL | YVFGGVRSRE | DIQGSEMVTC | KSEFYHDEFK |
550:
RWIYLNDQNL | CIPASSSFVY | GAVPIGASIY | VIGDLDTGTN | YDYVREFKRS |
597:
TGTWHHTKPL | LPSDLRRTGC | AALRIANCKL | FRLQLQQGLF | RIRVHSP
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
ELISA Kit for Mouse Gigaxonin
ELISA Kit for Mouse Gigaxonin
CLIA Kit for Mouse Gigaxonin
CLIA Kit for Mouse Gigaxonin
Polyclonal Antibody for Mouse Gigaxonin
Polyclonal Antibody for Mouse Gigaxonin
Monoclonal Antibody for Mouse Gigaxonin
Monoclonal Antibody for Mouse Gigaxonin
Protein for Mouse Gigaxonin
Protein for Mouse Gigaxonin
R&D Technical Data
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
Precision
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Recovery
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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Linearity
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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[
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[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-597
strain :
C57BL/6J .
tissue :
Spinal cord .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-597
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION
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[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH MAP1S;DISRUPTION PHENOTYPE
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DISRUPTION PHENOTYPE