Protein name:
    Gigaxonin ;
    
    Alternative:
    
    
    
 
    Organism:
        
        
        
        
        
        
    
        Mouse  (Mus musculus).  
    
 
General Annotation
    Sub Unit:
    Interacts with TBCB. Interacts with CUL3. Part of a complex that contains CUL3, RBX1 and GAN. Interacts (via BTB domain) with UBA1 (By similarity). Interacts (via Kelch domains) with MAP1B (via C-terminus) and MAP1S (via C-terminus).
    
 
    Function:
    Probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. Substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Controls degradation of TBCB (By similarity). Controls degradation of MAP1B and MAP1S, and is critical for neuronal maintenance and survival.
    
 
    
        
        Subcellular Location:
        
    
     
     
      Cytoplasm  
      cytoskeleton 
     
  
    
 
    
    Protein Attributes:
    
    50:
    MAEGSAVSDP |  QHAARLLRAL |  SSFREEARFC |  DAHLVLDGEE |  IPVQKNILAA |  
    
 
    100:
    ASPYIRTKLN |  YNPPKDDGST |  YKIELEGISV |  MVMREILDYI |  FSGQIRLNED |  
    
 
    150:
    TIQDVVQAAD |  LLLLTDLKTL |  CCEFLEGCIA |  AENCIGIRDF |  ALHYCLHHVH |  
    
 
    200:
    YLATEYLETH |  FRDVSSTEEF |  LELSPQKLKE |  VISLEKLNVG |  NERYVFEAVI |  
    
 
    250:
    RWIAHDVEMR |  KVHMKDVMSA |  LWVSGLDSSY |  LREQMLNEPL |  VREIVKECSN |  
    
 
    300:
    IPLSQPQQGE |  AMLASFKPRG |  YSECIVTIGG |  EERVSRKPTA |  AMRCMCPLYD |  
    
 
    350:
    PNRQLWIELA |  PLSMPRINHG |  VLSAEGFLFV |  LGGQDENKQT |  LSSGEKYDPD |  
    
 
    400:
    ANTWTALPPM |  HEARHNFGIV |  EIDGMLYILG |  GEDGDRELIS |  MECYDIYSKT |  
    
 
    450:
    WTKQPDLTMV |  RKIGCYAAMK |  KKIYAMGGGS |  YGKLFESVEC |  YDPRTQQWTA |  
    
 
    500:
    ICPLKERRFG |  AVACGVAMEL |  YVFGGVRSRE |  DIQGSEMVTC |  KSEFYHDEFK |  
    
 
    550:
    RWIYLNDQNL |  CIPASSSFVY |  GAVPIGASIY |  VIGDLDTGTN |  YDYVREFKRS |  
    
 
    597:
    TGTWHHTKPL |  LPSDLRRTGC |  AALRIANCKL |  FRLQLQQGLF |  RIRVHSP
    
 
      Vaild Sequence:
    
 
Related Databases
Uniprot:
 
 
    
        
        ELISA Kit
         
        
        CLIA Kit
         
        
        Polyclonal Antibody
         
        
        Monoclonal Antibody
         
        
        Protein
         
        
     
FOR
    
        
        Human
         
        
        Mouse
         
        
     
    
        ELISA Kit for Mouse Gigaxonin
        
     
    
    
    
    
    
    
 
    
        ELISA Kit for Mouse Gigaxonin
        
     
    
    
    
    
    
    
 
    
        CLIA Kit for Mouse Gigaxonin
        
     
    
    
    
    
    
    
 
    
        CLIA Kit for Mouse Gigaxonin
        
     
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Mouse Gigaxonin
        
     
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Mouse Gigaxonin
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Mouse Gigaxonin
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Mouse Gigaxonin
        
     
    
    
    
    
    
    
 
    
        Protein for Mouse Gigaxonin
        
     
    
    
    
    
    
    
 
    
        Protein for Mouse Gigaxonin
        
     
    
    
    
    
    
    
 
 
 
 
 
 
 
 
    R&D Technical Data
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
 
    Precision
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
 
    Recovery
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
 
    Linearity
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
    
        For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    
    
 
    
    
    References
    
    
        
            
        
            
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                        [
PubMed ]
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Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA] 
                    
                    
                    strain :
                    
C57BL/6J .  
             
         
            
        
            
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                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-597 
                    
                    
                    strain :
                    
C57BL/6J . tissue :
                    
Spinal cord .  
             
         
            
        
            
                3.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-597 
                    
                    
                 
             
         
            
        
            
                4.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for INTERACTION WITH MAP1B;SUBCELLULAR LOCATION;TISSUE SPECIFICITY 
                    
                    
                 
             
         
            
        
            
                5.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for FUNCTION 
                    
                    
                 
             
         
            
        
            
                6.
                
                    
                        
                            "Gene targeting of GAN in mouse causes a toxic accumulation of microtubule-associated protein 8 and impaired retrograde axonal transport." 
                        
                        
                            Ding J. 
                        ,
                            
Allen E. 
                        ,
                            
Wang W. 
                        ,
                            
Valle A. 
                        ,
                            
Wu C. 
                        ,
                            
Nardine T. 
                        ,
                            
Cui B. 
                        ,
                            
Yi J. 
                        ,
                            
Taylor A. 
                        ,
                            
Jeon N.L. 
                        ,
                            
Chu S. 
                        ,
                            
So Y. 
                        ,
                            
Vogel H. 
                        ,
                            
Tolwani R. 
                        ,
                            
Mobley W. 
                        ,
                            
Yang Y. 
                        
                        
                        
                        
                            Hum. Mol. Genet.15:1451-1463(2006)
                         
                        
                        
                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for FUNCTION;INTERACTION WITH MAP1S;DISRUPTION PHENOTYPE 
                    
                    
                 
             
         
            
        
            
                7.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for DISRUPTION PHENOTYPE