Protein name:
Growth arrest-specific protein 6 (GAS-6) ;
Alternative:
AXL receptor tyrosine kinase ligand ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Heterodimer and heterotetramer with AXL.
Function:
Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.
Subcellular Location:
Secreted
Protein Attributes:
50:
MAPSLSPGPA | ALRRAPQLLL | LLLAAECALA | ALLPAREATQ | FLRPRQRRAF |
100:
QVFEEAKQGH | LERECVEELC | SREEAREVFE | NDPETDYFYP | RYLDCINKYG |
150:
SPYTKNSGFA | TCVQNLPDQC | TPNPCDRKGT | QACQDLMGNF | FCLCKAGWGG |
200:
RLCDKDVNEC | SQENGGCLQI | CHNKPGSFHC | SCHSGFELSS | DGRTCQDIDE |
250:
CADSEACGEA | RCKNLPGSYS | CLCDEGFAYS | SQEKACRDVD | ECLQGRCEQV |
300:
CVNSPGSYTC | HCDGRGGLKL | SQDMDTCELE | AGWPCPRHRR | DGSPAARPGR |
350:
GAQGSRSEGH | IPDRRGPRPW | QDILPCVPFS | VAKSVKSLYL | GRMFSGTPVI |
400:
RLRFKRLQPT | RLVAEFDFRT | FDPEGILLFA | GGHQDSTWIV | LALRAGRLEL |
450:
QLRYNGVGRV | TSSGPVINHG | MWQTISVEEL | ARNLVIKVNR | DAVMKIAVAG |
500:
DLFQPERGLY | HLNLTVGGIP | FHEKDLVQPI | NPRLDGCMRS | WNWLNGEDTT |
550:
IQETVKVNTR | MQCFSVTERG | SFYPGSGFAF | YSLDYMRTPL | DVGTESTWEV |
600:
EVVAHIRPAA | DTGVLFALWA | PDLRAVPLSV | ALVDYHSTKK | LKKQLVVLAV |
650:
EHTALALMEI | KVCDGQEHVV | TVSLRDGEAT | LEVDGTRGQS | EVSAAQLQER |
700:
LAVLERHLRS | PVLTFAGGLP | DVPVTSAPVT | AFYRGCMTLE | VNRRLLDLDE |
721:
AAYKHSDITA | HSCPPVEPAA | A
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Rat
Human
ELISA Kit for Human GAS-6
ELISA Kit for Human GAS-6
ELISA Kit for Human GAS-6
Polyclonal Antibody for Human GAS-6
Polyclonal Antibody for Human GAS-6
Polyclonal Antibody for Human GAS-6
Monoclonal Antibody for Human GAS-6
Monoclonal Antibody for Human GAS-6
Monoclonal Antibody for Human GAS-6
R&D Technical Data
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Precision
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Recovery
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Linearity
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION OF THE GAS6/AXL SIGNALING PATHWAY
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION OF THE GAS6/AXL SIGNALING PATHWAY
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 261-721 (ISOFORM 2);MUTAGENESIS OF PHE-530; LEU-663 AND TYR-703;INTERACTION WITH AXL
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF 322-721 IN COMPLEX WITH AXL;SUBUNIT;GLYCOSYLATION AT ASN-463;MUTAGENESIS OF ARG-353 AND LYS-355