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Index > Protein center > GAS6(Gene name) > Human
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  • GAS6 (Gene name),
  • Growth arrest-specific protein 6 (Protein name ),  GAS6_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    GAS6(AXLLG);
    Protein name:
    Growth arrest-specific protein 6(GAS-6);
    Alternative:
    AXL receptor tyrosine kinase ligand;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Heterodimer and heterotetramer with AXL.
    Function:
    Ligand for tyrosine-protein kinase receptors AXL, TYRO3 and MER whose signaling is implicated in cell growth and survival, cell adhesion and cell migration. GAS6/AXL signaling plays a role in various processes such as endothelial cell survival during acidification by preventing apoptosis, optimal cytokine signaling during human natural killer cell development, hepatic regeneration, gonadotropin-releasing hormone neuron survival and migration, platelet activation, or regulation of thrombotic responses.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    721
    Sequence:
    50:
    MAPSLSPGPA | ALRRAPQLLL | LLLAAECALA | ALLPAREATQ | FLRPRQRRAF | 
    100:
    QVFEEAKQGH | LERECVEELC | SREEAREVFE | NDPETDYFYP | RYLDCINKYG | 
    150:
    SPYTKNSGFA | TCVQNLPDQC | TPNPCDRKGT | QACQDLMGNF | FCLCKAGWGG | 
    200:
    RLCDKDVNEC | SQENGGCLQI | CHNKPGSFHC | SCHSGFELSS | DGRTCQDIDE | 
    250:
    CADSEACGEA | RCKNLPGSYS | CLCDEGFAYS | SQEKACRDVD | ECLQGRCEQV | 
    300:
    CVNSPGSYTC | HCDGRGGLKL | SQDMDTCELE | AGWPCPRHRR | DGSPAARPGR | 
    350:
    GAQGSRSEGH | IPDRRGPRPW | QDILPCVPFS | VAKSVKSLYL | GRMFSGTPVI | 
    400:
    RLRFKRLQPT | RLVAEFDFRT | FDPEGILLFA | GGHQDSTWIV | LALRAGRLEL | 
    450:
    QLRYNGVGRV | TSSGPVINHG | MWQTISVEEL | ARNLVIKVNR | DAVMKIAVAG | 
    500:
    DLFQPERGLY | HLNLTVGGIP | FHEKDLVQPI | NPRLDGCMRS | WNWLNGEDTT | 
    550:
    IQETVKVNTR | MQCFSVTERG | SFYPGSGFAF | YSLDYMRTPL | DVGTESTWEV | 
    600:
    EVVAHIRPAA | DTGVLFALWA | PDLRAVPLSV | ALVDYHSTKK | LKKQLVVLAV | 
    650:
    EHTALALMEI | KVCDGQEHVV | TVSLRDGEAT | LEVDGTRGQS | EVSAAQLQER | 
    700:
    LAVLERHLRS | PVLTFAGGLP | DVPVTSAPVT | AFYRGCMTLE | VNRRLLDLDE | 
    721:
    AAYKHSDITA | HSCPPVEPAA | A
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    Pfam:
    UniGene:
    SMR:
    String:
    KEGG:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human GAS-6
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    ELISA Kit for Human GAS-6
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    CLIA Kit for Human GAS-6
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    CLIA Kit for Human GAS-6
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    CLIA Kit for Human GAS-6
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    Packing:
    96T
    Polyclonal Antibody for Human GAS-6
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    P1906Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human GAS-6
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    P1906Rb-h
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    Polyclonal Antibody for Human GAS-6
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    P1906Rb-r
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human GAS-6
    Monoclonal Antibody for Human GAS-6
    Monoclonal Antibody for Human GAS-6
    Protein for Human GAS-6
    Protein for Human GAS-6
    Protein for Human GAS-6

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    References
    1. 1.
      "The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade."
      Manfioletti G. , Brancolini C. , Avanzi G. , Schneider C.
      Mol. Cell. Biol.13:4976-4985(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);TISSUE SPECIFICITY
      tissue: Cervix carcinoma.
    2. 2.
      "Human vitamin K-dependent GAS6: gene structure, allelic variation, and association with stroke."
      Munoz X. , Sumoy L. , Ramirez-Lorca R. , Villar J. , de Frutos P.G. , Sala N.
      Hum. Mutat.23:506-512(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3; 4 AND 5)
      tissue: Kidney.
      tissue: Uterus.
    4. 4.
      SeattleSNPs variation discovery resource
      Submitted (2007-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS LEU-41; TYR-231; MET-390; ARG-543; LEU-623; LYS-655 AND GLN-659
    5. 5.
      "The DNA sequence and analysis of human chromosome 13."
      Dunham A. , Matthews L.H. , Burton J. , Ashurst J.L. , Howe K.L. , Ashcroft K.J. , Beare D.M. , Burford D.C. , Hunt S.E. , Griffiths-Jones S. , Jones M.C. , Keenan S.J. , Oliver K. , Scott C.E. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews D.T. , more...
      Nature428:522-528(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Fetal lung.
      tissue: Fetal spleen.
    7. 7.
      Maree A.O. , Hillmann A. , McRedmond J.P. , Fitzgerald D.J.
      Submitted (2002-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-85
    8. 8.
      "Axl receptor tyrosine kinase stimulated by the vitamin K-dependent protein encoded by growth-arrest-specific gene 6."
      Varnum B.C. , Young C. , Elliott G. , Garcia A. , Bartley T.D. , Fridell Y.W. , Hunt R.W. , Trail G. , Clogston C. , Toso R.J. , Yanagihara D. , Bennett L. , Silber M. , Merewether L.A. , Tseng A. , Escobar E. , Liu E.T. , Yamane H.K.
      Nature373:623-626(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: RECEPTOR INTERACTION
    9. 9.
      "The anticoagulation factor protein S and its relative, Gas6, are ligands for the Tyro 3/Axl family of receptor tyrosine kinases."
      Stitt T.N. , Conn G. , Gore M. , Lai C. , Bruno J. , Radziejewski C. , Mattsson K. , Fisher J. , Gies D.R. , Jones P.F. , Masiakowski P. , Ryan T.E. , Tobkes N.J. , Chen D.H. , DiStefano P.S. , Long G.L. , Basilico C. , Goldfarb M.P. , more...
      Cell80:661-670(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: RECEPTOR INTERACTION
    10. 10.
      "Identification and tissue expression of a splice variant for the growth arrest-specific gene gas6."
      Marcandalli P. , Gostissa M. , Varnum B. , Goruppi S. , Schneider C.
      FEBS Lett.415:56-58(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORM 1);TISSUE SPECIFICITY
    11. 11.
      "Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases."
      Nagata K. , Ohashi K. , Nakano T. , Arita H. , Zong C. , Hanafusa H. , Mizuno K.
      J. Biol. Chem.271:30022-30027(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: RECEPTOR INTERACTION
    12. 12.
      "The product of a gas6 splice variant allows the release of the domain responsible for Axl tyrosine kinase receptor activation."
      Goruppi S. , Yamane H. , Marcandalli P. , Garcia A. , Clogston C. , Gostissa M. , Varnum B. , Schneider C.
      FEBS Lett.415:59-63(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: RECEPTOR INTERACTION;SUBCELLULAR LOCATION;PROTEOLYTIC PROCESSING
    13. 13.
      "Acidification prevents endothelial cell apoptosis by Axl activation."
      D'Arcangelo D. , Gaetano C. , Capogrossi M.C.
      Circ. Res.91:E4-12(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION OF THE GAS6/AXL SIGNALING PATHWAY
    14. 14.
      "The Axl/Gas6 pathway is required for optimal cytokine signaling during human natural killer cell development."
      Park I.K. , Giovenzana C. , Hughes T.L. , Yu J. , Trotta R. , Caligiuri M.A.
      Blood113:2470-2477(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION OF THE GAS6/AXL SIGNALING PATHWAY
    15. 15.
      "Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl."
      Mark M.R. , Chen J. , Hammonds R.G. , Sadick M. , Godowski P.J.
      J. Biol. Chem.271:9785-9789(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 261-721 (ISOFORM 2);MUTAGENESIS OF PHE-530; LEU-663 AND TYR-703;INTERACTION WITH AXL
    16. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.3 ANGSTROMS) OF 322-721 IN COMPLEX WITH AXL;SUBUNIT;GLYCOSYLATION AT ASN-463;MUTAGENESIS OF ARG-353 AND LYS-355
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