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Index > Protein center > GBP1(Gene name) > Human
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  • GBP1 (Gene name),
  • Interferon-induced guanylate-binding protein 1 (Protein name ),  GBP1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    GBP1;
    Protein name:
    Interferon-induced guanylate-binding protein 1;
    Alternative:
    Guanine nucleotide-binding protein 1;GTP-binding protein 1(GBP-1;HuGBP-1);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Binds GTP, GDP and GMP.
    Subcellular Location:
    Cell membrane Lipid-anchor Cytoplasmic side
    Protein Attributes:
    Sequence length:
    592
    Sequence:
    50:
    MASEIHMTGP | MCLIENTNGR | LMANPEALKI | LSAITQPMVV | VAIVGLYRTG | 
    100:
    KSYLMNKLAG | KKKGFSLGST | VQSHTKGIWM | WCVPHPKKPG | HILVLLDTEG | 
    150:
    LGDVEKGDNQ | NDSWIFALAV | LLSSTFVYNS | IGTINQQAMD | QLYYVTELTH | 
    200:
    RIRSKSSPDE | NENEVEDSAD | FVSFFPDFVW | TLRDFSLDLE | ADGQPLTPDE | 
    250:
    YLTYSLKLKK | GTSQKDETFN | LPRLCIRKFF | PKKKCFVFDR | PVHRRKLAQL | 
    300:
    EKLQDEELDP | EFVQQVADFC | SYIFSNSKTK | TLSGGIQVNG | PRLESLVLTY | 
    350:
    VNAISSGDLP | CMENAVLALA | QIENSAAVQK | AIAHYEQQMG | QKVQLPTETL | 
    400:
    QELLDLHRDS | EREAIEVFIR | SSFKDVDHLF | QKELAAQLEK | KRDDFCKQNQ | 
    450:
    EASSDRCSAL | LQVIFSPLEE | EVKAGIYSKP | GGYRLFVQKL | QDLKKKYYEE | 
    500:
    PRKGIQAEEI | LQTYLKSKES | MTDAILQTDQ | TLTEKEKEIE | VERVKAESAQ | 
    550:
    ASAKMLQEMQ | RKNEQMMEQK | ERSYQEHLKQ | LTEKMENDRV | QLLKEQERTL | 
    592:
    ALKLQEQEQL | LKEGFQKESR | IMKNEIQDLQ | TKMRRRKACT | IS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    UniGene:
    MIM:
    String:
    KEGG:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Interferon-induced guanylate-binding protein 1
    ELISA Kit for Human Interferon-induced guanylate-binding protein 1
    CLIA Kit for Human Interferon-induced guanylate-binding protein 1
    CLIA Kit for Human Interferon-induced guanylate-binding protein 1
    Polyclonal Antibody for Human Interferon-induced guanylate-binding protein 1
    Polyclonal Antibody for Human Interferon-induced guanylate-binding protein 1
    Monoclonal Antibody for Human Interferon-induced guanylate-binding protein 1
    Monoclonal Antibody for Human Interferon-induced guanylate-binding protein 1
    Protein for Human Interferon-induced guanylate-binding protein 1
    Protein for Human Interferon-induced guanylate-binding protein 1

    R&D Technical Data
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Interferon-induced guanylate-binding proteins lack an N(T)KXD consensus motif and bind GMP in addition to GDP and GTP."
      Cheng Y.-S.E. , Patterson C.E. , Staeheli P.
      Mol. Cell. Biol.11:4717-4725(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANTS SER-349 AND GLY-409
    2. 2.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS SER-349 AND GLY-409
    3. 3.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Placenta.
    4. 4.
      "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G. , Barlow K.F. , McLay K.E. , Kaul R. , Swarbreck D. , Dunham A. , Scott C.E. , Howe K.L. , Woodfine K. , Spencer C.C.A. , Jones M.C. , Gillson C. , Searle S. , Zhou Y. , Kokocinski F. , McDonald L. , Evans R. , Phillips K. , more...
      Nature441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANTS SER-349 AND GLY-409
      tissue: Uterus.
    7. 7.
      "Prenylation of an interferon-gamma-induced GTP-binding protein: the human guanylate binding protein, huGBP1."
      Nantais D.E. , Schwemmle M. , Stickney J.T. , Vestal D.J. , Buss J.E.
      J. Leukoc. Biol.60:423-431(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ISOPRENYLATION AT CYS-589
    8. 8.
      "Golgi targeting of human guanylate-binding protein-1 requires nucleotide binding, isoprenylation, and an IFN-gamma-inducible cofactor."
      Modiano N. , Lu Y.E. , Cresswell P.
      Proc. Natl. Acad. Sci. U.S.A.102:8680-8685(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    9. 9.
      "Human guanylate binding protein-1 is a secreted GTPase present in increased concentrations in the cerebrospinal fluid of patients with bacterial meningitis."
      Naschberger E. , Lubeseder-Martellato C. , Meyer N. , Gessner R. , Kremmer E. , Gessner A. , Sturzl M.
      Am. J. Pathol.169:1088-1099(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    10. 10.
      "Unique features of different members of the human guanylate-binding protein family."
      Tripal P. , Bauer M. , Naschberger E. , Mortinger T. , Hohenadl C. , Cornali E. , Thurau M. , Sturzl M.
      J. Interferon Cytokine Res.27:44-52(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;INDUCTION
    11. 11.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    12. 12.
      "Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner."
      Britzen-Laurent N. , Bauer M. , Berton V. , Fischer N. , Syguda A. , Reipschlager S. , Naschberger E. , Herrmann C. , Sturzl M.
      PLoS ONE5:E14246-E14246(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;SUBUNIT
    13. 13.
      "A new splice variant of the human guanylate-binding protein 3 mediates anti-influenza activity through inhibition of viral transcription and replication."
      Nordmann A. , Wixler L. , Boergeling Y. , Wixler V. , Ludwig S.
      FASEB J.26:1290-1300(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
    14. 14.
      "Structure of human guanylate-binding protein 1 representing a unique class of GTP-binding proteins."
      Prakash B. , Praefcke G.J.K. , Renault L. , Wittinghofer A. , Herrmann C.
      Nature403:567-571(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.8 ANGSTROMS)
    15. 15.
      "Triphosphate structure of guanylate-binding protein 1 and implications for nucleotide binding and GTPase mechanism."
      Prakash B. , Renault L. , Praefcke G.J. , Herrmann C. , Wittinghofer A.
      EMBO J.19:4555-4564(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) IN COMPLEX WITH GTP ANALOG
    16. 16.
      "How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP."
      Ghosh A. , Praefcke G.J. , Renault L. , Wittinghofer A. , Herrmann C.
      Nature440:101-104(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.22 ANGSTROMS) OF 1-317;SUBUNIT
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