GCKR ELISA Kit for Human(Homo sapiens) | EIAab.comGCKR ELISA Kit for Human(Homo sapiens)

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Index > Protein center > GCKR(Gene name) > Human

GCKR (Gene name),

Glucokinase regulatory protein (Protein name ), GCKR_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

GCKR;

Protein name:

Glucokinase regulatory protein(Glucokinase regulator);

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Inhibits glucokinase by forming an inactive complex with this enzyme.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

625

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

625:

VRSALAGPGQ | KRTADPLEIL | EPDVQ

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

KEGG:

hsa:2646

STRING:

9606.ENSP00000264717

SMR:

Q14397

String:

Q14397

MIM:

600842

UniGene:

Hs.89771

Uniprot:

Q14397

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ELISA Kit for Human Glucokinase regulator

Cat.:

E1365h

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Manual:

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MSDS:

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Packing:

96T

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ELISA Kit for Human Glucokinase regulator

Cat.:

E1365m

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MSDS:

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Packing:

96T

ELISA Kit for Human Glucokinase regulator

Cat.:

E1365r

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Packing:

96T

CLIA Kit for Human Glucokinase regulator

Cat.:

U1365m

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MSDS:

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Packing:

96T

CLIA Kit for Human Glucokinase regulator

Cat.:

U1365h

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Glucokinase regulator

Cat.:

U1365r

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Packing:

96T

Polyclonal Antibody for Human Glucokinase regulator

Cat.:

P1365Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Glucokinase regulator

Cat.:

P1365Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Glucokinase regulator

Cat.:

P1365Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Glucokinase regulator

Protein for Human Glucokinase regulator

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Human glucokinase regulatory protein (GCKR): cDNA and genomic cloning, complete primary structure, and chromosomal localization."
Warner J.P. , Leek J.P. , Intody S. , Markham A.F. , Bonthron D.T.
Mamm. Genome6:532-536(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA]
tissue: Hepatoblastoma.
2.

"Organization of the human glucokinase regulator gene GCKR."
Hayward B.E. , Dunlop N. , Intody S. , Leek J.P. , Markham A.F. , Warner J.P. , Bonthron D.T.
Genomics49:137-142(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL NUCLEOTIDE SEQUENCE [GENOMIC DNA];SEQUENCE REVISION TO 393 AND 560;TISSUE SPECIFICITY
3.

NIEHS SNPs program
Submitted (2003-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS GLY-77; SER-256; LEU-446 AND GLN-540
4.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue: Liver.
5.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT LEU-446
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
7.

"Glucokinase regulatory protein is essential for the proper subcellular localisation of liver glucokinase."
de la Iglesia N. , Veiga-da-Cunha M. , Van Schaftingen E. , Guinovart J.J. , Ferrer J.C.
FEBS Lett.456:332-338(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION;SUBUNIT
8.

"The common P446L polymorphism in GCKR inversely modulates fasting glucose and triglyceride levels and reduces type 2 diabetes risk in the DESIR prospective general French population."
Vaxillaire M. , Cavalcanti-Proenca C. , Dechaume A. , Tichet J. , Marre M. , Balkau B. , Froguel P.
Diabetes57:2253-2257(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN FGQTL5;VARIANT LEU-446;ASSOCIATION WITH LOWER RISK FOR DIABETES TYPE 2
9.

"The P446L variant in GCKR associated with fasting plasma glucose and triglyceride levels exerts its effect through increased glucokinase activity in liver."
Beer N.L. , Tribble N.D. , McCulloch L.J. , Roos C. , Johnson P.R. , Orho-Melander M. , Gloyn A.L.
Hum. Mol. Genet.18:4081-4088(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;CHARACTERIZATION OF VARIANT LEU-446
10.

"Molecular basis for the role of glucokinase regulatory protein as the allosteric switch for glucokinase."
Choi J.M. , Seo M.H. , Kyeong H.H. , Kim E. , Kim H.S.
Proc. Natl. Acad. Sci. U.S.A.110:10171-10176(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH GCK;MUTAGENESIS OF ASP-413 AND 463-LEU--PHE-465
11.

"Crystal structure of glucokinase regulatory protein."
Pautsch A. , Stadler N. , Lohle A. , Rist W. , Berg A. , Glocker L. , Nar H. , Reinert D. , Lenter M. , Heckel A. , Schnapp G. , Kauschke S.G.
Biochemistry52:3523-3531(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.47 ANGSTROMS) IN COMPLEX WITH FRUCTOSE-1-PHOSPHATE;FUNCTION;INTERACTION WITH GCK;MUTAGENESIS OF 326-LYS-LYS-327 AND 450-LYS-LYS-451
12.

"Common missense variant in the glucokinase regulatory protein gene is associated with increased plasma triglyceride and C-reactive protein but lower fasting glucose concentrations."
Orho-Melander M. , Melander O. , Guiducci C. , Perez-Martinez P. , Corella D. , Roos C. , Tewhey R. , Rieder M.J. , Hall J. , Abecasis G. , Tai E.S. , Welch C. , Arnett D.K. , Lyssenko V. , Lindholm E. , Saxena R. , de Bakker P.I. , Burtt N. , more...
Diabetes57:3112-3121(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LEU-446;INVOLVEMENT IN FGQTL5;ASSOCIATION WITH HIGH PLASMA TRIGLYCERIDE LEVELS

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