Protein name:
Glucocorticoid receptor (GR) ;
Alternative:
Nuclear receptor subfamily 3 group C member 1 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Heteromultimeric cytoplasmic complex with HSP90, HSP70, and FKBP5 or another immunophilin, or the immunophilin homolog PPP5C. Directly interacts with UNC45A. Upon ligand binding FKBP5 dissociates from the complex and FKBP4 takes its place, thereby linking the complex to dynein and mediating transport to the nucleus, where the complex dissociates (By similarity). Binds to DNA as a homodimer, and as a heterodimer with NR3C2 or the retinoid X receptor. Binds STAT5A and STAT5B homodimers and heterodimers. Interacts with NRIP1, POU2F1, POU2F2 and TRIM28. Interacts with NCOA1, NCOA3, SMARCA4, SMARCC1, SMARCD1, and SMARCE1 (By similarity). Interacts with several coactivator complexes, including the SMARCA4 complex, CREBBP/EP300, TADA2L and p160 coactivators such as NCOA2 and NCOA6. Interaction with BAG1 inhibits transactivation. Interacts with HEXIM1, PELP1 and TGFB1I1.
Function:
Receptor for glucocorticoids (GC). Has a dual mode of action: as a transcription factor that binds to glucocorticoid response elements (GRE) and as a modulator of other transcription factors. Affects inflammatory responses, cellular proliferation and differentiation in target tissues. Could act as a coactivator for STAT5-dependent transcription upon growth hormone (GH) stimulation and could reveal an essential role of hepatic GR in the control of body growth. Involved in chromatin remodeling. Plays a significant role in transactivation. Involved in nuclear translocation.
Subcellular Location:
Isoform Beta
Nucleus
Localized largely in the nucleus.
Protein Attributes:
50:
MDSKESLTPG | REENPSSVLA | QERGDVMDFY | KTLRGGATVK | VSASSPSLAV |
100:
ASQSDSKQRR | LLVDFPKGSV | SNAQQPDLSK | AVSLSMGLYM | GETETKVMGN |
150:
DLGFPQQGQI | SLSSGETDLK | LLEESIANLN | RSTSVPENPK | SSASTAVSAA |
200:
PTEKEFPKTH | SDVSSEQQHL | KGQTGTNGGN | VKLYTTDQST | FDILQDLEFS |
250:
SGSPGKETNE | SPWRSDLLID | ENCLLSPLAG | EDDSFLLEGN | SNEDCKPLIL |
300:
PDTKPKIKDN | GDLVLSSPSN | VTLPQVKTEK | EDFIELCTPG | VIKQEKLGTV |
350:
YCQASFPGAN | IIGNKMSAIS | VHGVSTSGGQ | MYHYDMNTAS | LSQQQDQKPI |
400:
FNVIPPIPVG | SENWNRCQGS | GDDNLTSLGT | LNFPGRTVFS | NGYSSPSMRP |
450:
DVSSPPSSSS | TATTGPPPKL | CLVCSDEASG | CHYGVLTCGS | CKVFFKRAVE |
500:
GQHNYLCAGR | NDCIIDKIRR | KNCPACRYRK | CLQAGMNLEA | RKTKKKIKGI |
550:
QQATTGVSQE | TSENPGNKTI | VPATLPQLTP | TLVSLLEVIE | PEVLYAGYDS |
600:
SVPDSTWRIM | TTLNMLGGRQ | VIAAVKWAKA | IPGFRNLHLD | DQMTLLQYSW |
650:
MFLMAFALGW | RSYRQSSANL | LCFAPDLIIN | EQRMTLPCMY | DQCKHMLYVS |
700:
SELHRLQVSY | EEYLCMKTLL | LLSSVPKDGL | KSQELFDEIR | MTYIKELGKA |
750:
IVKREGNSSQ | NWQRFYQLTK | LLDSMHEVVE | NLLNYCFQTF | LDKTMSIEFP |
777:
EMLAEIITNQ | IPKYSNGNIK | KLLFHQK
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Rat
Mouse
Pig
Rabbit
Polyclonal Antibody for Human GR
Polyclonal Antibody for Human GR
Polyclonal Antibody for Human GR
Polyclonal Antibody for Human GR
Polyclonal Antibody for Human GR
Monoclonal Antibody for Human GR
Monoclonal Antibody for Human GR
Monoclonal Antibody for Human GR
Monoclonal Antibody for Human GR
Monoclonal Antibody for Human GR
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS ALPHA AND BETA)
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Fibroblast .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS ALPHA AND BETA)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA-2)
tissue :
Osteosarcoma .
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA)
tissue :
Kidney .
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA)
tissue :
Uterine endothelium .
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS LYS-23 AND VAL-65
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
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Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA)
tissue :
Placenta .
13.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-394
14.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-394
15.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DOMAINS
16.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ALTERNATIVE SPLICING (ISOFORMS GP-P; GP-A ALPHA AND GP-A BETA)
17.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH TADA2L AND THE ADA COMPLEX;MUTAGENESIS OF PHE-191; ILE-193; LEU-194; LEU-197; TRP-213; LEU-224; LEU-225; PHE-235 AND LEU-236
18.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH THE SMARCA4 COMPLEX; NCOA1; NCOA2 AND THE CREBBP/EP300 COMPLEX
19.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH BAG1
20.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ALTERNATIVE SPLICING (ISOFORMS ALPHA-2 AND BETA-2)
21.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY
22.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH NCOA6
23.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : EFFECT ON EXPANDED POLYGLUTAMINE PROTEIN
24.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : GLUCOCORTICOID-MEDIATED DOWN-REGULATION
25.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REDUCTION OF CELL DEATH IN RESPONSE TO CORTICOSTEROIDS
26.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ALTERNATIVE INITIATION;MUTAGENESIS OF MET-1 AND MET-27
27.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : SUMOYLATION;MUTAGENESIS OF LYS-277; LYS-293 AND LYS-703
28.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-203 AND SER-211
29.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH PELP1
30.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : REVIEW ON ALTERNATIVE SPLICING;ALTERNATIVE INITIATION
31.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH TGFB1I1
32.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH HEXIM1
33.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH UNC45A
34.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
35.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
36.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-134 AND SER-267;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
37.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;ACETYLATION AT LYS-480; LYS-492; LYS-494 AND LYS-495;MUTAGENESIS OF LYS-480; LYS-492; LYS-494 AND LYS-495;INTERACTION WITH CLOCK
38.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Leukemic T-cell .
39.
"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V.
,
Vermeulen M.
,
Santamaria A.
,
Kumar C.
,
Miller M.L.
,
Jensen L.J.
,
Gnad F.
,
Cox J.
,
Jensen T.S.
,
Nigg E.A.
,
Brunak S.
,
Mann M.
Sci. Signal.3:RA3-RA3(2010)
[
PubMed ]
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Europe PMC ]
[
Abstract ]
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue :
Cervix carcinoma .
40.
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
41.
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Cited for : SUBCELLULAR LOCATION;FUNCTION
42.
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Cited for : SUBCELLULAR LOCATION;SUBUNIT
43.
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Cited for : INTERACTION WITH CRY1 AND CRY2
44.
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Cited for : ACETYLATION;INTERACTION WITH CLOCK
45.
"N-terminal acetylome analyses and functional insights of the N-terminal acetyltransferase NatB."
Van Damme P.
,
Lasa M.
,
Polevoda B.
,
Gazquez C.
,
Elosegui-Artola A.
,
Kim D.S.
,
De Juan-Pardo E.
,
Demeyer K.
,
Hole K.
,
Larrea E.
,
Timmerman E.
,
Prieto J.
,
Arnesen T.
,
Sherman F.
,
Gevaert K.
,
Aldabe R.
Proc. Natl. Acad. Sci. U.S.A.109:12449-12454(2012)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
46.
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Cited for : MUTAGENESIS OF LYS-703
47.
"Crystal structure of the glucocorticoid receptor ligand binding domain reveals a novel mode of receptor dimerization and coactivator recognition."
Bledsoe R.K.
,
Montana V.G.
,
Stanley T.B.
,
Delves C.J.
,
Apolito C.J.
,
McKee D.D.
,
Consler T.G.
,
Parks D.J.
,
Stewart E.L.
,
Willson T.M.
,
Lambert M.H.
,
Moore J.T.
,
Pearce K.H.
,
Xu H.E.
Cell110:93-105(2002)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 521-777 OF MUTANT SER-602 IN COMPLEX WITH NCOA2; DEXAMETHASONE AND RU-486;MUTAGENESIS OF ARG-585; ASP-590; PHE-602; PRO-625 AND ILE-628
48.
"The three-dimensional structures of antagonistic and agonistic forms of the glucocorticoid receptor ligand-binding domain: RU-486 induces a transconformation that leads to active antagonism."
Kauppi B.
,
Jakob C.
,
Faernegaardh M.
,
Yang J.
,
Ahola H.
,
Alarcon M.
,
Calles K.
,
Engstrom O.
,
Harlan J.
,
Muchmore S.
,
Ramqvist A.-K.
,
Thorell S.
,
Oehman L.
,
Greer J.
,
Gustafsson J.-A.
,
Carlstedt-Duke J.
,
Carlquist M.
J. Biol. Chem.278:22748-22754(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS) OF 500-777 OF MUTANT SER-602 IN COMPLEX WITH COACTIVATOR PEPTIDE; DEXAMETHASONE AND WITH RU-486
49.
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Cited for : CHARACTERIZATION OF VARIANT GCRES VAL-641
50.
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Cited for : VARIANTS TYR-421 AND PHE-753
51.
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Cited for : VARIANT SER-363
52.
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Cited for : VARIANT GCRES ILE-729
53.
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Cited for : VARIANT PHE-753
54.
"Lack of association between five polymorphisms in the human glucocorticoid receptor gene and glucocorticoid resistance."
Koper J.W.
,
Stolk R.P.
,
de Lange P.
,
Huizenga N.A.T.M.
,
Molijn G.-J.
,
Pols H.A.P.
,
Grobbee D.E.
,
Karl M.
,
de Jong F.H.
,
Brinkmann A.O.
,
Lamberts S.W.J.
Hum. Genet.99:663-668(1997)
[
PubMed ]
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Europe PMC ]
[
Abstract ]
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Cited for : VARIANTS LYS-23 AND SER-363
55.
"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Cargill M.
,
Altshuler D.
,
Ireland J.
,
Sklar P.
,
Ardlie K.
,
Patil N.
,
Shaw N.
,
Lane C.R.
,
Lim E.P.
,
Kalyanaraman N.
,
Nemesh J.
,
Ziaugra L.
,
Friedland L.
,
Rolfe A.
,
Warrington J.
,
Lipshutz R.
,
Daley G.Q.
,
Lander E.S.
Nat. Genet.22:231-238(1999)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : VARIANTS LYS-23; VAL-65 AND SER-363
56.
Cargill M.
,
Altshuler D.
,
Ireland J.
,
Sklar P.
,
Ardlie K.
,
Patil N.
,
Shaw N.
,
Lane C.R.
,
Lim E.P.
,
Kalyanaraman N.
,
Nemesh J.
,
Ziaugra L.
,
Friedland L.
,
Rolfe A.
,
Warrington J.
,
Lipshutz R.
,
Daley G.Q.
,
Lander E.S.
Nat. Genet.23:373-373(1999)
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Cited for : ERRATUM
57.
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Cited for : VARIANTS LYS-23; LEU-29; PHE-112; ASN-233 AND SER-363
58.
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Cited for : VARIANTS GCRES HIS-477 AND SER-679
59.
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Cited for : VARIANT SER-363
60.
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Cited for : CHARACTERIZATION OF VARIANT GCRES ASN-559
61.
"A polymorphism in the glucocorticoid receptor gene, which decreases sensitivity to glucocorticoids in vivo, is associated with low insulin and cholesterol levels."
van Rossum E.F.C.
,
Koper J.W.
,
Huizenga N.A.T.M.
,
Uitterlinden A.G.
,
Janssen J.A.M.J.L.
,
Brinkmann A.O.
,
Grobbee D.E.
,
de Jong F.H.
,
van Duyn C.M.
,
Pols H.A.P.
,
Lamberts S.W.J.
Diabetes51:3128-3134(2002)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : VARIANT LYS-23
62.
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Cited for : VARIANT PSEUDOHERMAPHRODITISM ALA-571
63.
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Cited for : VARIANT GCRES MET-747;ALTERED INTERACTION WITH THE COACTIVATOR NCOA2
64.
"Association of the ER22/23EK polymorphism in the glucocorticoid receptor gene with survival and C-reactive protein levels in elderly men."
van Rossum E.F.C.
,
Feelders R.A.
,
van den Beld A.W.
,
Uitterlinden A.G.
,
Janssen J.A.M.J.L.
,
Ester W.
,
Brinkmann A.O.
,
Grobbee D.E.
,
de Jong F.H.
,
Pols H.A.P.
,
Koper J.W.
,
Lamberts S.W.J.
Am. J. Med.117:158-162(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : VARIANT LYS-23
65.
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Cited for : VARIANT LYS-23