Protein name:
    Growth/differentiation factor 8 (GDF-8) ;
    
    Alternative:
    
    Myostatin ;
    
    
 
    Organism:
        
        
        
        
        
        
    
        Human  (Homo sapiens).  
    
 
General Annotation
    Sub Unit:
    Homodimer; disulfide-linked (By similarity). Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FST3.
    
 
    Function:
    Acts specifically as a negative regulator of skeletal muscle growth.
    
 
    
        
        Subcellular Location:
        
    
    Secreted
    
 
    
    Protein Attributes:
    
    50:
    MQKLQLCVYI |  YLFMLIVAGP |  VDLNENSEQK |  ENVEKEGLCN |  ACTWRQNTKS |  
    
 
    100:
    SRIEAIKIQI |  LSKLRLETAP |  NISKDVIRQL |  LPKAPPLREL |  IDQYDVQRDD |  
    
 
    150:
    SSDGSLEDDD |  YHATTETIIT |  MPTESDFLMQ |  VDGKPKCCFF |  KFSSKIQYNK |  
    
 
    200:
    VVKAQLWIYL |  RPVETPTTVF |  VQILRLIKPM |  KDGTRYTGIR |  SLKLDMNPGT |  
    
 
    250:
    GIWQSIDVKT |  VLQNWLKQPE |  SNLGIEIKAL |  DENGHDLAVT |  FPGPGEDGLN |  
    
 
    300:
    PFLEVKVTDT |  PKRSRRDFGL |  DCDEHSTESR |  CCRYPLTVDF |  EAFGWDWIIA |  
    
 
    350:
    PKRYKANYCS |  GECEFVFLQK |  YPHTHLVHQA |  NPRGSAGPCC |  TPTKMSPINM |  
    
 
    375:
    LYFNGKEQII |  YGKIPAMVVD |  RCGCS
    
 
      Vaild Sequence:
    
 
Related Databases
Uniprot:
 
 
    
        
        ELISA Kit
         
        
        CLIA Kit
         
        
        Polyclonal Antibody
         
        
        Monoclonal Antibody
         
        
        Protein
         
        
     
FOR
    
        
        Human
         
        
        Mouse
         
        
        Rat
         
        
        Chicken
         
        
        Dog
         
        
        Pig
         
        
        Bovine
         
        
     
    
        ELISA Kit for Human GDF-8
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
    
    
    
    
 
    
        ELISA Kit for Human GDF-8
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
    
    
    
    
 
    
        ELISA Kit for Human GDF-8
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
    
    
    
    
 
    
        ELISA Kit for Human GDF-8
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
    
    
    
    
 
    
        ELISA Kit for Human GDF-8
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
    
    
    
    
 
    
        ELISA Kit for Human GDF-8
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        ELISA Kit for Human GDF-8
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human GDF-8
        
     
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human GDF-8
        
     
    
    
    
    
   
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human GDF-8
        
     
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human GDF-8
        
     
    
    
    
    
   
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human GDF-8
        
     
    
    
    
    
   
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human GDF-8
        
     
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Human GDF-8
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human GDF-8
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human GDF-8
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human GDF-8
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human GDF-8
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human GDF-8
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human GDF-8
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Human GDF-8
        
     
    
    
    
    
    
    
 
 
 
 
 
 
 
 
    R&D Technical Data
    
    
    
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    Precision
    
    
    
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    Recovery
    
    
    
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    Linearity
    
    
    
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    Citations
    
    
    
        [1].
        
        
            
            MI Yilmaz, A Sonmez, M Saglam, et al.
            
            
         
     
    
 
    
    
    References
    
    
        
            
        
            
                1.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [MRNA] 
                    
                    
                    tissue :
                    
Skeletal muscle .  
             
         
            
        
            
                2.
                
                    
                        
                            "Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting." 
                        
                        
                            Gonzalez-Cadavid N.F. 
                        ,
                            
Taylor W.E. 
                        ,
                            
Yarasheski K. 
                        ,
                            
Sinha-Hikim I. 
                        ,
                            
Ma K. 
                        ,
                            
Ezzat S. 
                        ,
                            
Shen R. 
                        ,
                            
Lalani R. 
                        ,
                            
Asa S. 
                        ,
                            
Mamita M. 
                        ,
                            
Nair G. 
                        ,
                            
Arver S. 
                        ,
                            
Bhasin S. 
                        
                        
                        
                        
                            Proc. Natl. Acad. Sci. U.S.A.95:14938-14943(1998)
                         
                        
                        
                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [MRNA] 
                    
                    
                    tissue :
                    
Muscle .  
             
         
            
        
            
                3.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS THR-55 AND ARG-153 
                    
                    
                 
             
         
            
        
            
                4.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] 
                    
                    
                    tissue :
                    
Colon .  
             
         
            
        
            
                5.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for INTERACTION WITH WFIKKN2 
                    
                    
                 
             
         
            
        
            
                6.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for INVOLVEMENT IN MSLHP 
                    
                    
                 
             
         
            
        
            
                7.
                
                    
                        
                            "Characterization of follistatin-related gene as a negative regulatory factor for activin family members during mouse heart development." 
                        
                        
                            Takehara-Kasamatsu Y. 
                        ,
                            
Tsuchida K. 
                        ,
                            
Nakatani M. 
                        ,
                            
Murakami T. 
                        ,
                            
Kurisaki A. 
                        ,
                            
Hashimoto O. 
                        ,
                            
Ohuchi H. 
                        ,
                            
Kurose H. 
                        ,
                            
Mori K. 
                        ,
                            
Kagami S. 
                        ,
                            
Noji S. 
                        ,
                            
Sugino H. 
                        
                        
                        
                        
                            J. Med. Invest.54:276-288(2007)
                         
                        
                        
                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for INTERACTION WITH FSTL3