Protein name:
Growth/differentiation factor 8 (GDF-8) ;
Alternative:
Myostatin ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homodimer; disulfide-linked (By similarity). Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FST3.
Function:
Acts specifically as a negative regulator of skeletal muscle growth.
Subcellular Location:
Secreted
Protein Attributes:
50:
MQKLQLCVYI | YLFMLIVAGP | VDLNENSEQK | ENVEKEGLCN | ACTWRQNTKS |
100:
SRIEAIKIQI | LSKLRLETAP | NISKDVIRQL | LPKAPPLREL | IDQYDVQRDD |
150:
SSDGSLEDDD | YHATTETIIT | MPTESDFLMQ | VDGKPKCCFF | KFSSKIQYNK |
200:
VVKAQLWIYL | RPVETPTTVF | VQILRLIKPM | KDGTRYTGIR | SLKLDMNPGT |
250:
GIWQSIDVKT | VLQNWLKQPE | SNLGIEIKAL | DENGHDLAVT | FPGPGEDGLN |
300:
PFLEVKVTDT | PKRSRRDFGL | DCDEHSTESR | CCRYPLTVDF | EAFGWDWIIA |
350:
PKRYKANYCS | GECEFVFLQK | YPHTHLVHQA | NPRGSAGPCC | TPTKMSPINM |
375:
LYFNGKEQII | YGKIPAMVVD | RCGCS
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
Chicken
Dog
Pig
Bovine
ELISA Kit for Human GDF-8
ELISA Kit for Human GDF-8
ELISA Kit for Human GDF-8
ELISA Kit for Human GDF-8
ELISA Kit for Human GDF-8
ELISA Kit for Human GDF-8
ELISA Kit for Human GDF-8
Polyclonal Antibody for Human GDF-8
Polyclonal Antibody for Human GDF-8
Polyclonal Antibody for Human GDF-8
Polyclonal Antibody for Human GDF-8
Polyclonal Antibody for Human GDF-8
Polyclonal Antibody for Human GDF-8
Polyclonal Antibody for Human GDF-8
Monoclonal Antibody for Human GDF-8
Monoclonal Antibody for Human GDF-8
Monoclonal Antibody for Human GDF-8
Monoclonal Antibody for Human GDF-8
Monoclonal Antibody for Human GDF-8
Monoclonal Antibody for Human GDF-8
Monoclonal Antibody for Human GDF-8
R&D Technical Data
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Precision
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Recovery
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Linearity
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Citations
[1].
MI Yilmaz, A Sonmez, M Saglam, et al.
References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Skeletal muscle .
2.
"Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting."
Gonzalez-Cadavid N.F.
,
Taylor W.E.
,
Yarasheski K.
,
Sinha-Hikim I.
,
Ma K.
,
Ezzat S.
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Asa S.
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Mamita M.
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Nair G.
,
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,
Bhasin S.
Proc. Natl. Acad. Sci. U.S.A.95:14938-14943(1998)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
tissue :
Muscle .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS THR-55 AND ARG-153
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue :
Colon .
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH WFIKKN2
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INVOLVEMENT IN MSLHP
7.
"Characterization of follistatin-related gene as a negative regulatory factor for activin family members during mouse heart development."
Takehara-Kasamatsu Y.
,
Tsuchida K.
,
Nakatani M.
,
Murakami T.
,
Kurisaki A.
,
Hashimoto O.
,
Ohuchi H.
,
Kurose H.
,
Mori K.
,
Kagami S.
,
Noji S.
,
Sugino H.
J. Med. Invest.54:276-288(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH FSTL3