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Index > Protein center > MSTN(Gene name) > Human
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  • MSTN (Gene name),
  • Growth/differentiation factor 8 (Protein name ),  GDF8_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Citations  (1)
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  • Gene name:
    MSTN(GDF8);
    Protein name:
    Growth/differentiation factor 8(GDF-8);
    Alternative:
    Myostatin;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer; disulfide-linked (By similarity). Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FST3.
    Function:
    Acts specifically as a negative regulator of skeletal muscle growth.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    375
    Sequence:
    50:
    MQKLQLCVYI | YLFMLIVAGP | VDLNENSEQK | ENVEKEGLCN | ACTWRQNTKS | 
    100:
    SRIEAIKIQI | LSKLRLETAP | NISKDVIRQL | LPKAPPLREL | IDQYDVQRDD | 
    150:
    SSDGSLEDDD | YHATTETIIT | MPTESDFLMQ | VDGKPKCCFF | KFSSKIQYNK | 
    200:
    VVKAQLWIYL | RPVETPTTVF | VQILRLIKPM | KDGTRYTGIR | SLKLDMNPGT | 
    250:
    GIWQSIDVKT | VLQNWLKQPE | SNLGIEIKAL | DENGHDLAVT | FPGPGEDGLN | 
    300:
    PFLEVKVTDT | PKRSRRDFGL | DCDEHSTESR | CCRYPLTVDF | EAFGWDWIIA | 
    350:
    PKRYKANYCS | GECEFVFLQK | YPHTHLVHQA | NPRGSAGPCC | TPTKMSPINM | 
    375:
    LYFNGKEQII | YGKIPAMVVD | RCGCS
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    String:
    UniGene:
    SMR:
    KEGG:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human GDF-8
    Cat.:
    E1653h
    Price:
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human GDF-8
    Cat.:
    E1653m
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human GDF-8
    Cat.:
    E1653r
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human GDF-8
    Cat.:
    E1653c
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    MSDS:
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    96T
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    ELISA Kit for Human GDF-8
    Cat.:
    E1653d
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    MSDS:
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    96T
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    ELISA Kit for Human GDF-8
    Cat.:
    E1653p
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human GDF-8
    Cat.:
    E1653b
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human GDF-8
    Cat.:
    U1653b
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human GDF-8
    Cat.:
    U1653d
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human GDF-8
    Cat.:
    U1653p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human GDF-8
    Cat.:
    U1653c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human GDF-8
    Cat.:
    U1653r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human GDF-8
    Cat.:
    U1653m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human GDF-8
    Cat.:
    U1653h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human GDF-8
    Polyclonal Antibody for Human GDF-8
    Cat.:
    P1653Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human GDF-8
    Polyclonal Antibody for Human GDF-8
    Cat.:
    P1653Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human GDF-8
    Cat.:
    P1653Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human GDF-8
    Polyclonal Antibody for Human GDF-8
    Monoclonal Antibody for Human GDF-8
    Monoclonal Antibody for Human GDF-8
    Monoclonal Antibody for Human GDF-8
    Monoclonal Antibody for Human GDF-8
    Monoclonal Antibody for Human GDF-8
    Monoclonal Antibody for Human GDF-8
    Monoclonal Antibody for Human GDF-8
    Protein for Human GDF-8
    Protein for Human GDF-8
    Protein for Human GDF-8
    Protein for Human GDF-8
    Protein for Human GDF-8
    Protein for Human GDF-8
    Protein for Human GDF-8

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    References
    1. 1.
      "Double muscling in cattle due to mutations in the myostatin gene."
      McPherron A.C. , Lee S.-J.
      Proc. Natl. Acad. Sci. U.S.A.94:12457-12461(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Skeletal muscle.
    2. 2.
      "Organization of the human myostatin gene and expression in healthy men and HIV-infected men with muscle wasting."
      Gonzalez-Cadavid N.F. , Taylor W.E. , Yarasheski K. , Sinha-Hikim I. , Ma K. , Ezzat S. , Shen R. , Lalani R. , Asa S. , Mamita M. , Nair G. , Arver S. , Bhasin S.
      Proc. Natl. Acad. Sci. U.S.A.95:14938-14943(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Muscle.
    3. 3.
      "Human adaptive evolution at myostatin (GDF8), a regulator of muscle growth."
      Saunders M.A. , Good J.M. , Lawrence E.C. , Ferrell R.E. , Li W.H. , Nachman M.W.
      Am. J. Hum. Genet.79:1089-1097(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS THR-55 AND ARG-153
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Colon.
    5. 5.
      "Regulation of myostatin in vivo by growth and differentiation factor-associated serum protein-1: a novel protein with protease inhibitor and follistatin domains."
      Hill J.J. , Qiu Y. , Hewick R.M. , Wolfman N.M.
      Mol. Endocrinol.17:1144-1154(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH WFIKKN2
    6. 6.
      "Myostatin mutation associated with gross muscle hypertrophy in a child."
      Schuelke M. , Wagner K.R. , Stolz L.E. , Hubner C. , Riebel T. , Komen W. , Braun T. , Tobin J.F. , Lee S.J.
      N. Engl. J. Med.350:2682-2688(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN MSLHP
    7. 7.
      "Characterization of follistatin-related gene as a negative regulatory factor for activin family members during mouse heart development."
      Takehara-Kasamatsu Y. , Tsuchida K. , Nakatani M. , Murakami T. , Kurisaki A. , Hashimoto O. , Ohuchi H. , Kurose H. , Mori K. , Kagami S. , Noji S. , Sugino H.
      J. Med. Invest.54:276-288(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FSTL3
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