Protein name:
Growth/differentiation factor 8 (GDF-8) ;
Alternative:
Myostatin ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Homodimer; disulfide-linked (By similarity). Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FST3.
Function:
Acts specifically as a negative regulator of skeletal muscle growth.
Subcellular Location:
Secreted
Protein Attributes:
50:
MMQKLQMYVY | IYLFMLIAAG | PVDLNEGSER | EENVEKEGLC | NACAWRQNTR |
100:
YSRIEAIKIQ | ILSKLRLETA | PNISKDAIRQ | LLPRAPPLRE | LIDQYDVQRD |
150:
DSSDGSLEDD | DYHATTETII | TMPTESDFLM | QADGKPKCCF | FKFSSKIQYN |
200:
KVVKAQLWIY | LRPVKTPTTV | FVQILRLIKP | MKDGTRYTGI | RSLKLDMSPG |
250:
TGIWQSIDVK | TVLQNWLKQP | ESNLGIEIKA | LDENGHDLAV | TFPGPGEDGL |
300:
NPFLEVKVTD | TPKRSRRDFG | LDCDEHSTES | RCCRYPLTVD | FEAFGWDWII |
350:
APKRYKANYC | SGECEFVFLQ | KYPHTHLVHQ | ANPRGSAGPC | CTPTKMSPIN |
376:
MLYFNGKEQI | IYGKIPAMVV | DRCGCS
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
Chicken
Dog
Pig
Bovine
ELISA Kit for Mouse GDF-8
ELISA Kit for Mouse GDF-8
ELISA Kit for Mouse GDF-8
ELISA Kit for Mouse GDF-8
ELISA Kit for Mouse GDF-8
ELISA Kit for Mouse GDF-8
ELISA Kit for Mouse GDF-8
Polyclonal Antibody for Mouse GDF-8
Polyclonal Antibody for Mouse GDF-8
Polyclonal Antibody for Mouse GDF-8
Polyclonal Antibody for Mouse GDF-8
Polyclonal Antibody for Mouse GDF-8
Polyclonal Antibody for Mouse GDF-8
Polyclonal Antibody for Mouse GDF-8
Monoclonal Antibody for Mouse GDF-8
Monoclonal Antibody for Mouse GDF-8
Monoclonal Antibody for Mouse GDF-8
Monoclonal Antibody for Mouse GDF-8
Monoclonal Antibody for Mouse GDF-8
Monoclonal Antibody for Mouse GDF-8
Monoclonal Antibody for Mouse GDF-8
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
CD-1 .
tissue :
Skeletal muscle .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH WFIKKN2
3.
"BMP signaling controls muscle mass."
Sartori R.
,
Schirwis E.
,
Blaauw B.
,
Bortolanza S.
,
Zhao J.
,
Enzo E.
,
Stantzou A.
,
Mouisel E.
,
Toniolo L.
,
Ferry A.
,
Stricker S.
,
Goldberg A.L.
,
Dupont S.
,
Piccolo S.
,
Amthor H.
,
Sandri M.
Nat. Genet.45:1309-1318(2013)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : DISRUPTION PHENOTYPE
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.15 ANGSTROMS) OF 268-376 IN COMPLEX WITH HUMAN FOLLISTATIN;HEPARIN-BINDING;DISULFIDE BONDS
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 268-376 IN COMPLEX WITH HUMAN FSTL3;DISULFIDE BONDS