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Index > Protein center > GFRA1(Gene name) > Human
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  • GFRA1 (Gene name),
  • GDNF family receptor alpha-1 (Protein name ),  GFRA1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    GFRA1(GDNFRA;RETL1;TRNR1);
    Protein name:
    GDNF family receptor alpha-1(GDNF receptor alpha-1;GDNFR-alpha-1;GFR-alpha-1);
    Alternative:
    TGF-beta-related neurotrophic factor receptor 1;RET ligand 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    2 molecules of GDNFR-alpha are thought to form a complex with the disulfide-linked GDNF dimer and with 2 molecules of RET.
    Function:
    Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor.
    Subcellular Location:
    Cell membrane Lipid-anchor GPI-anchor
    Protein Attributes:
    Sequence length:
    465
    Sequence:
    50:
    MFLATLYFAL | PLLDLLLSAE | VSGGDRLDCV | KASDQCLKEQ | SCSTKYRTLR | 
    100:
    QCVAGKETNF | SLASGLEAKD | ECRSAMEALK | QKSLYNCRCK | RGMKKEKNCL | 
    150:
    RIYWSMYQSL | QGNDLLEDSP | YEPVNSRLSD | IFRVVPFISD | VFQQVEHIPK | 
    200:
    GNNCLDAAKA | CNLDDICKKY | RSAYITPCTT | SVSNDVCNRR | KCHKALRQFF | 
    250:
    DKVPAKHSYG | MLFCSCRDIA | CTERRRQTIV | PVCSYEEREK | PNCLNLQDSC | 
    300:
    KTNYICRSRL | ADFFTNCQPE | SRSVSSCLKE | NYADCLLAYS | GLIGTVMTPN | 
    350:
    YIDSSSLSVA | PWCDCSNSGN | DLEECLKFLN | FFKDNTCLKN | AIQAFGNGSD | 
    400:
    VTVWQPAFPV | QTTTATTTTA | LRVKNKPLGP | AGSENEIPTH | VLPPCANLQA | 
    450:
    QKLKSNVSGN | THLCISNGNY | EKEGLGASSH | ITTKSMAAPP | SCGLSPLLVL | 
    465:
    VVTALSTLLS | LTETS
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    UniGene:
    KEGG:
    String:
    MIM:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human GDNF receptor alpha-1
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    E2753h
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    96T
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    ELISA Kit for Human GDNF receptor alpha-1
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    E2753r
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    ELISA Kit for Human GDNF receptor alpha-1
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    E2753m
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    96T
    ELISA Kit for Human GDNF receptor alpha-1
    Cat.:
    E2753c
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    Packing:
    96T
    CLIA Kit for Human GDNF receptor alpha-1
    Cat.:
    U2753c
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human GDNF receptor alpha-1
    Cat.:
    U2753m
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human GDNF receptor alpha-1
    Cat.:
    U2753r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human GDNF receptor alpha-1
    Cat.:
    U2753h
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    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
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    Polyclonal Antibody for Human GDNF receptor alpha-1
    Cat.:
    P2753Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human GDNF receptor alpha-1
    Polyclonal Antibody for Human GDNF receptor alpha-1
    Cat.:
    P2753Rb-h
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    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human GDNF receptor alpha-1
    Cat.:
    P2753Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human GDNF receptor alpha-1
    Monoclonal Antibody for Human GDNF receptor alpha-1
    Monoclonal Antibody for Human GDNF receptor alpha-1
    Monoclonal Antibody for Human GDNF receptor alpha-1
    Protein for Human GDNF receptor alpha-1
    Protein for Human GDNF receptor alpha-1
    Protein for Human GDNF receptor alpha-1
    Protein for Human GDNF receptor alpha-1

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    References
    1. 1.
      "GDNF-induced activation of the ret protein tyrosine kinase is mediated by GDNFR-alpha, a novel receptor for GDNF."
      Jing S. , Wen D. , Yu Y. , Holst P.L. , Luo Y. , Fang M. , Tamir R. , Antonio L. , Hu Z. , Cupples R. , Louis J.-C. , Hu S. , Altrock B.W. , Fox G.M.
      Cell85:1113-1124(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE (ISOFORM 1)
      tissue: Substantia nigra.
    2. 2.
      "Glial cell line-derived neurotrophic factor-dependent RET activation can be mediated by two different cell-surface accessory proteins."
      Sanicola M. , Hession C.A. , Worley D.S. , Carmillo P. , Ehrenfels C. , Walus L. , Robinson S. , Jaworski G. , Wei H. , Tizard R. , Whitty A. , Pepinsky R.B. , Cate R.L.
      Proc. Natl. Acad. Sci. U.S.A.94:6238-6243(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      tissue: Kidney.
    3. 3.
      "Human GFRA1: cloning, mapping, genomic structure, and evaluation as a candidate gene for Hirschsprung disease susceptibility."
      Angrist M. , Jing S. , Bolk S. , Bentley K. , Nallasamy S. , Halushka M. , Fox G.M. , Chakravarti A.
      Genomics48:354-362(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1);VARIANTS ASN-85 AND ALA-366
    4. 4.
      "Mutational analysis of the GDNF/RET-GDNFR-alpha signaling complex in a kindred with vesicoureteral reflux."
      Shefelbine S.E. , Khorana S. , Schultz P.N. , Huang E. , Thobe N. , Hu Z.J. , Fox G.M. , Jing S. , Cote G.J. , Gagel R.F.
      Hum. Genet.102:474-478(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Thyroid carcinoma.
    5. 5.
      "GDNF-induced differentiation and its enhancement by retinoic acid in primary human neuroblastomas expressing c-Ret and GDNFR-alpha."
      Hishiki T. , Kondoh K. , Ichimiya S. , Nimura Y. , Seki N. , Ozaki T. , Sakiyama S. , Takahashi H. , Ohnuma N. , Tanabe M. , Fujimura S. , Nakagawara A.
      Submitted (1997-10) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      tissue: Substantia nigra.
    6. 6.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Trachea.
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
      tissue: Eye.
    9. 9.
      "An unappreciated role for RNA surveillance."
      Hillman R.T. , Green R.E. , Brenner S.E.
      Genome Biol.5:R8.1-R8.16(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S)
    10. 10.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ALA-366 AND ARG-371
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