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Index > Protein center > GHR(Gene name) > Human
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  • GHR (Gene name),
  • Growth hormone receptor (Protein name ),  GHR_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    GHR;
    Protein name:
    Growth hormone receptor(GH receptor);
    Alternative:
    Somatotropin receptor;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    On growth hormone (GH) binding, forms homodimers and binds JAK2 via a box 1-containing domain (By similarity). Binding to SOCS3 inhibits JAK2 activation, binding to CIS and SOCS2 inhibits STAT5 activation (By similarity). Interacts with ADAM17.
    Function:
    Isoform 2 up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling.
    Subcellular Location:
    Growth hormone-binding protein Secreted
    Protein Attributes:
    Sequence length:
    638
    Sequence:
    50:
    MDLWQLLLTL | ALAGSSDAFS | GSEATAAILS | RAPWSLQSVN | PGLKTNSSKE | 
    100:
    PKFTKCRSPE | RETFSCHWTD | EVHHGTKNLG | PIQLFYTRRN | TQEWTQEWKE | 
    150:
    CPDYVSAGEN | SCYFNSSFTS | IWIPYCIKLT | SNGGTVDEKC | FSVDEIVQPD | 
    200:
    PPIALNWTLL | NVSLTGIHAD | IQVRWEAPRN | ADIQKGWMVL | EYELQYKEVN | 
    250:
    ETKWKMMDPI | LTTSVPVYSL | KVDKEYEVRV | RSKQRNSGNY | GEFSEVLYVT | 
    300:
    LPQMSQFTCE | EDFYFPWLLI | IIFGIFGLTV | MLFVFLFSKQ | QRIKMLILPP | 
    350:
    VPVPKIKGID | PDLLKEGKLE | EVNTILAIHD | SYKPEFHSDD | SWVEFIELDI | 
    400:
    DEPDEKTEES | DTDRLLSSDH | EKSHSNLGVK | DGDSGRTSCC | EPDILETDFN | 
    450:
    ANDIHEGTSE | VAQPQRLKGE | ADLLCLDQKN | QNNSPYHDAC | PATQQPSVIQ | 
    500:
    AEKNKPQPLP | TEGAESTHQA | AHIQLSNPSS | LSNIDFYAQV | SDITPAGSVV | 
    550:
    LSPGQKNKAG | MSQCDMHPEM | VSLCQENFLM | DNAYFCEADA | KKCIPVAPHI | 
    600:
    KVESHIQPSL | NQEDIYITTE | SLTTAAGRPG | TGEHVPGSEM | PVPDYTSIHI | 
    638:
    VQSPQGLILN | ATALPLPDKE | FLSSCGYVST | DQLNKIMP
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    SMR:
    UniGene:
    KEGG:
    String:
    MIM:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human GH receptor
    Cat.:
    E1036h
    Price:
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human GH receptor
    Cat.:
    E1036p
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    MSDS:
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    Packing:
    96T
    Range:
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    ELISA Kit for Human GH receptor
    Cat.:
    E1036m
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human GH receptor
    Cat.:
    E1036c
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human GH receptor
    Cat.:
    E1036d
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human GH receptor
    Cat.:
    E1036r
    Price:
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    MSDS:
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    Packing:
    96T
    ELISA Kit for Human GH receptor
    MSDS:
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    ELISA Kit for Human GH receptor
    Cat.:
    E1036b
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human GH receptor
    Cat.:
    U1036d
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human GH receptor
    Cat.:
    U1036r
    Price:
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human GH receptor
    Cat.:
    U1036c
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human GH receptor
    Cat.:
    U1036p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human GH receptor
    Cat.:
    U1036m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human GH receptor
    Cat.:
    U1036b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human GH receptor
    Cat.:
    U1036h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human GH receptor
    MSDS:
    Please sign in first.
    Polyclonal Antibody for Human GH receptor
    Cat.:
    P1036Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human GH receptor
    Cat.:
    P1036Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human GH receptor
    Polyclonal Antibody for Human GH receptor
    Cat.:
    P1036Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human GH receptor
    Polyclonal Antibody for Human GH receptor
    Polyclonal Antibody for Human GH receptor
    Polyclonal Antibody for Human GH receptor
    Monoclonal Antibody for Human GH receptor
    Monoclonal Antibody for Human GH receptor
    Monoclonal Antibody for Human GH receptor
    Monoclonal Antibody for Human GH receptor
    Monoclonal Antibody for Human GH receptor
    Monoclonal Antibody for Human GH receptor
    Monoclonal Antibody for Human GH receptor
    Monoclonal Antibody for Human GH receptor
    Protein for Human GH receptor
    Cat.:
    R1036h
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%
    Protein for Human GH receptor
    Protein for Human GH receptor
    Protein for Human GH receptor
    Protein for Human GH receptor
    Protein for Human GH receptor
    Protein for Human GH receptor
    Protein for Human GH receptor

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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Growth hormone receptor and serum binding protein: purification, cloning and expression."
      Leung D.W. , Spencer S.A. , Cachianes G. , Hammonds R.G. , Collins C. , Henzel W.J. , Barnard R. , Waters M.J. , Wood W.I.
      Nature330:537-543(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PARTIAL PROTEIN SEQUENCE
      tissue: Liver.
    2. 2.
      "Characterization of the human growth hormone receptor gene and demonstration of a partial gene deletion in two patients with Laron-type dwarfism."
      Godowski P.J. , Leung D.W. , Meacham L.R. , Galgani J.P. , Hellmiss R. , Keret R. , Rotwein P.S. , Parks J.S. , Laron Z. , Wood W.I.
      Proc. Natl. Acad. Sci. U.S.A.86:8083-8087(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1);VARIANT LEU-544
    3. 3.
      "Expression of a human growth hormone (hGH) receptor isoform is predicted by tissue-specific alternative splicing of exon 3 of the hGH receptor gene transcript."
      Urbanek M. , MacLeod J.N. , Cooke N.E. , Liebhaber S.A.
      Mol. Endocrinol.6:279-287(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4)
      tissue: Placenta.
    4. 4.
      "Alternatively spliced forms in the cytoplasmic domain of the human growth hormone (GH) receptor regulate its ability to generate a soluble GH-binding protein."
      Dastot F. , Sobrier M.-L. , Duquesnoy P. , Duriez B. , Goossens M. , Amselem S.
      Proc. Natl. Acad. Sci. U.S.A.93:10723-10728(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
      tissue: Liver.
    5. 5.
      "A membrane-fixed, truncated isoform of the human growth hormone receptor."
      Amit T. , Bergman T. , Dastot F. , Youdim M.B.H. , Amselem S. , Hochberg Z.
      J. Clin. Endocrinol. Metab.82:3813-3817(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
    6. 6.
      "A short isoform of the human growth hormone receptor functions as a dominant negative inhibitor of the full-length receptor and generates large amounts of binding protein."
      Ross R.J. , Esposito N. , Shen X.Y. , Von Laue S. , Chew S.L. , Dobson P.R. , Postel-Vinay M.-C. , Finidori J.
      Mol. Endocrinol.11:265-273(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3)
      tissue: Liver.
    7. 7.
      "Comparing of nucleotide sequences of alternatively spliced region of mammalian growth hormone receptor genes."
      Orlovsky I.V. , Borovikova I.E. , Rubtsov P.M.
      Submitted (2000-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 263-336
    8. 8.
      "Functional characterization of the alternatively spliced, placental human growth hormone receptor."
      Urbanek M. , Russell J.E. , Cooke N.E. , Liebhaber S.A.
      J. Biol. Chem.268:19025-19032(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION (ISOFORM 4)
    9. 9.
      "Species-specific alternative splice mimicry at the growth hormone receptor locus revealed by the lineage of retroelements during primate evolution."
      Pantel J. , Machinis K. , Sobrier M.-L. , Duquesnoy P. , Goossens M. , Amselem S.
      J. Biol. Chem.275:18664-18669(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MOLECULAR MECHANISM OF PRODUCTION (ISOFORM 4)
    10. 10.
      "The human growth hormone receptor. Secretion from Escherichia coli and disulfide bonding pattern of the extracellular binding domain."
      Fuh G. , Mulkerrin M.G. , Bass S. , McFarland N. , Brochier M. , Bourrel J.H. , Light D.R. , Wells J.A.
      J. Biol. Chem.265:3111-3115(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BONDS
    11. 11.
      "Identification of a region critical for proteolysis of the human growth hormone receptor."
      Conte F. , Salles J.P. , Raynal P. , Fernandez L. , Molinas C. , Tauber M. , Bieth E.
      Biochem. Biophys. Res. Commun.290:851-857(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SITE CRITICAL TO PROTEOLYSIS;MUTAGENESIS OF GLU-260; GLU-261 AND ASP-262
    12. 12.
      "Human growth hormone and extracellular domain of its receptor: crystal structure of the complex."
      de Vos A.M. , Ultsch M. , Kossiakoff A.A.
      Science255:306-312(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 19-254 IN COMPLEX WITH GROWTH HORMONE
    13. 13.
      "Crystal structure of an antagonist mutant of human growth hormone, G120R, in complex with its receptor at 2.9-A resolution."
      Sundstroem M. , Lundqvist T. , Roedin J. , Giebel L.B. , Milligan D. , Norstedt G.
      J. Biol. Chem.271:32197-32203(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 19-256 IN COMPLEX WITH GROWTH HORMONE
    14. 14.
      "Laron dwarfism and mutations of the growth hormone-receptor gene."
      Amselem S. , Duquesnoy P. , Attree O. , Novelli G. , Bousnina S. , Postel-Vinay M.-C. , Goossens M.
      N. Engl. J. Med.321:989-995(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LARS SER-114
    15. 15.
      "Amino acid substitutions in the intracellular part of the growth hormone receptor in a patient with the Laron syndrome."
      Kou K. , Lajara R. , Rotwein P.
      J. Clin. Endocrinol. Metab.76:54-59(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LARS PHE-440
    16. 16.
      "Spectrum of growth hormone receptor mutations and associated haplotypes in Laron syndrome."
      Amselem S. , Duquesnoy P. , Duriez B. , Dastot F. , Sobrier M.-L. , Valleix S. , Goossens M.
      Hum. Mol. Genet.2:355-359(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LARS LYS-89; GLN-149; ASP-162; CYS-179 AND GLY-229
    17. 17.
      "Lack of hormone binding in COS-7 cells expressing a mutated growth hormone receptor found in Laron dwarfism."
      Edery M. , Rozakis-Adcock M. , Goujon L. , Finidori J. , Levi-Meyrueis C. , Paly J. , Djiane J. , Postel-Vinay M.-C. , Kelly P.A.
      J. Clin. Invest.91:838-844(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT LARS SER-114
    18. 18.
      "A single amino acid substitution in the exoplasmic domain of the human growth hormone (GH) receptor confers familial GH resistance (Laron syndrome) with positive GH-binding activity by abolishing receptor homodimerization."
      Duquesnoy P. , Sobrier M.-L. , Duriez B. , Dastot F. , Buchanan C.R. , Savage M.O. , Preece M.A. , Craescu C.T. , Blouquit Y. , Goossens M. , Amselem S.
      EMBO J.13:1386-1395(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LARS HIS-170
    19. 19.
      "Mutations of the growth hormone receptor in children with idiopathic short stature."
      Goddard A.D. , Covello R. , Luoh S.-M. , Clackson T. , Attie K.M. , Gesundheit N. , Rundle A.C. , Wells J.A. , Carlsson L.M.S.
      N. Engl. J. Med.333:1093-1098(1995) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ISSA LYS-62 AND CYS-179;VARIANTS HIS-229 AND ASP-242
    20. 20.
      "Nine novel growth hormone receptor gene mutations in patients with Laron syndrome."
      Sobrier M.-L. , Dastot F. , Duquesnoy P. , Kandemir N. , Yordam N. , Goossens M. , Amselem S.
      J. Clin. Endocrinol. Metab.82:435-437(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LARS SER-56; LEU-58 AND ARG-68
    21. 21.
      "A novel mutation affecting the interdomain link region of the growth hormone receptor in a Vietnamese girl, and response to long-term treatment with recombinant human insulin-like growth factor-I and luteinizing hormone-releasing hormone analogue."
      Walker J.L. , Crock P.A. , Behncken S.N. , Rowlinson S.W. , Nicholson L.M. , Boulton T.J.C. , Waters M.J.
      J. Clin. Endocrinol. Metab.83:2554-2561(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LARS GLN-149;CHARACTERIZATION OF VARIANT LARS GLN-149
    22. 22.
      "Growth hormone receptor mutations in children with idiopathic short stature."
      Sanchez J.E. , Perera E. , Baumbach L. , Cleveland W.W.
      J. Clin. Endocrinol. Metab.83:4079-4083(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ILE-162
    23. 23.
      "Four contiguous amino acid substitutions, identified in patients with Laron syndrome, differently affect the binding affinity and intracellular trafficking of the growth hormone receptor."
      Wojcik J. , Berg M.A. , Esposito N. , Geffner M.E. , Sakati N. , Reiter E.O. , Dower S. , Francke U. , Postel-Vinay M.-C. , Finidori J.
      J. Clin. Endocrinol. Metab.83:4481-4489(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LARS HIS-170; THR-171; PRO-172 AND GLY-173;CHARACTERIZATION OF VARIANTS LARS THR-171; PRO-172 AND GLY-173
    24. 24.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HIS-179; HIS-229; PHE-440; THR-495; LEU-544 AND THR-579
    25. 25.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
    26. 26.
      "Characterisation of novel missense mutations in the GH receptor gene causing severe growth retardation."
      Enberg B. , Luthman H. , Segnestam K. , Ritzen E.M. , Sundstroem M. , Norstedt G.
      Eur. J. Endocrinol.143:71-76(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LARS CYS-226 AND ASN-262
    27. 27.
      "Growth hormone receptor variant (L526I) modifies plasma HDL cholesterol phenotype in familial hypercholesterolemia: intra-familial association study in an eight-generation hyperlipidemic kindred."
      Takada D. , Ezura Y. , Ono S. , Iino Y. , Katayama Y. , Xin Y. , Wu L.L. , Larringa-Shum S. , Stephenson S.H. , Hunt S.C. , Hopkins P.N. , Emi M.
      Am. J. Med. Genet. A121:136-140(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LEU-544
    28. 28.
      "The first homozygous mutation (S226I) in the highly-conserved WSXWS-like motif of the GH receptor causing Laron syndrome: suppression of GH secretion by GnRH analogue therapy not restored by dihydrotestosterone administration."
      Jorge A.A.L. , Souza S.C.A.L. , Arnhold I.J.P. , Mendonca B.B.
      Clin. Endocrinol. (Oxf.)60:36-40(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LARS ILE-244
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