GHR ELISA Kit for Human(Homo sapiens) | EIAab.comGHR ELISA Kit for Human(Homo sapiens)

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GHR (Gene name),

Growth hormone receptor (Protein name ), GHR_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

GHR;

Protein name:

Growth hormone receptor(GH receptor);

Alternative:

Somatotropin receptor;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

On growth hormone (GH) binding, forms homodimers and binds JAK2 via a box 1-containing domain (By similarity). Binding to SOCS3 inhibits JAK2 activation, binding to CIS and SOCS2 inhibits STAT5 activation (By similarity). Interacts with ADAM17.

Function:

Isoform 2 up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling.

Subcellular Location:

Growth hormone-binding protein Secreted

Protein Attributes:

Sequence length:

638

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

638:

VQSPQGLILN | ATALPLPDKE | FLSSCGYVST | DQLNKIMP

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

P10912

UniGene:

Hs.125180

KEGG:

hsa:2690

String:

P10912

MIM:

143890

STRING:

9606.ENSP00000230882

Pfam:

PF09067

Uniprot:

P10912

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ELISA Kit for Human GH receptor

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E1036h

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96T

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ELISA Kit for Human GH receptor

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E1036p

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96T

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ELISA Kit for Human GH receptor

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E1036m

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96T

ELISA Kit for Human GH receptor

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E1036c

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96T

ELISA Kit for Human GH receptor

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E1036d

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96T

ELISA Kit for Human GH receptor

Cat.:

E1036r

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96T

ELISA Kit for Human GH receptor

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ELISA Kit for Human GH receptor

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E1036b

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96T

CLIA Kit for Human GH receptor

Cat.:

U1036d

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96T

CLIA Kit for Human GH receptor

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U1036r

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96T

CLIA Kit for Human GH receptor

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U1036c

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96T

CLIA Kit for Human GH receptor

Cat.:

U1036p

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96T

CLIA Kit for Human GH receptor

Cat.:

U1036m

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96T

CLIA Kit for Human GH receptor

Cat.:

U1036b

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96T

CLIA Kit for Human GH receptor

Cat.:

U1036h

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CLIA Kit for Human GH receptor

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Polyclonal Antibody for Human GH receptor

Cat.:

P1036Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human GH receptor

Cat.:

P1036Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human GH receptor

Cat.:

P1036Rb-h

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Polyclonal Antibody for Human GH receptor

Monoclonal Antibody for Human GH receptor

Protein for Human GH receptor

Cat.:

R1036h

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Packing:

1mg

Purity:

>90%

Protein for Human GH receptor

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Growth hormone receptor and serum binding protein: purification, cloning and expression."
Leung D.W. , Spencer S.A. , Cachianes G. , Hammonds R.G. , Collins C. , Henzel W.J. , Barnard R. , Waters M.J. , Wood W.I.
Nature330:537-543(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);PARTIAL PROTEIN SEQUENCE
tissue: Liver.
2.

"Characterization of the human growth hormone receptor gene and demonstration of a partial gene deletion in two patients with Laron-type dwarfism."
Godowski P.J. , Leung D.W. , Meacham L.R. , Galgani J.P. , Hellmiss R. , Keret R. , Rotwein P.S. , Parks J.S. , Laron Z. , Wood W.I.
Proc. Natl. Acad. Sci. U.S.A.86:8083-8087(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1);VARIANT LEU-544
3.

"Expression of a human growth hormone (hGH) receptor isoform is predicted by tissue-specific alternative splicing of exon 3 of the hGH receptor gene transcript."
Urbanek M. , MacLeod J.N. , Cooke N.E. , Liebhaber S.A.
Mol. Endocrinol.6:279-287(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4)
tissue: Placenta.
4.

"Alternatively spliced forms in the cytoplasmic domain of the human growth hormone (GH) receptor regulate its ability to generate a soluble GH-binding protein."
Dastot F. , Sobrier M.-L. , Duquesnoy P. , Duriez B. , Goossens M. , Amselem S.
Proc. Natl. Acad. Sci. U.S.A.93:10723-10728(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
tissue: Liver.
5.

"A membrane-fixed, truncated isoform of the human growth hormone receptor."
Amit T. , Bergman T. , Dastot F. , Youdim M.B.H. , Amselem S. , Hochberg Z.
J. Clin. Endocrinol. Metab.82:3813-3817(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
6.

"A short isoform of the human growth hormone receptor functions as a dominant negative inhibitor of the full-length receptor and generates large amounts of binding protein."
Ross R.J. , Esposito N. , Shen X.Y. , Von Laue S. , Chew S.L. , Dobson P.R. , Postel-Vinay M.-C. , Finidori J.
Mol. Endocrinol.11:265-273(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3)
tissue: Liver.
7.

"Comparing of nucleotide sequences of alternatively spliced region of mammalian growth hormone receptor genes."
Orlovsky I.V. , Borovikova I.E. , Rubtsov P.M.
Submitted (2000-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 263-336
8.

"Functional characterization of the alternatively spliced, placental human growth hormone receptor."
Urbanek M. , Russell J.E. , Cooke N.E. , Liebhaber S.A.
J. Biol. Chem.268:19025-19032(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION (ISOFORM 4)
9.

"Species-specific alternative splice mimicry at the growth hormone receptor locus revealed by the lineage of retroelements during primate evolution."
Pantel J. , Machinis K. , Sobrier M.-L. , Duquesnoy P. , Goossens M. , Amselem S.
J. Biol. Chem.275:18664-18669(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MOLECULAR MECHANISM OF PRODUCTION (ISOFORM 4)
10.

"The human growth hormone receptor. Secretion from Escherichia coli and disulfide bonding pattern of the extracellular binding domain."
Fuh G. , Mulkerrin M.G. , Bass S. , McFarland N. , Brochier M. , Bourrel J.H. , Light D.R. , Wells J.A.
J. Biol. Chem.265:3111-3115(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BONDS
11.

"Identification of a region critical for proteolysis of the human growth hormone receptor."
Conte F. , Salles J.P. , Raynal P. , Fernandez L. , Molinas C. , Tauber M. , Bieth E.
Biochem. Biophys. Res. Commun.290:851-857(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SITE CRITICAL TO PROTEOLYSIS;MUTAGENESIS OF GLU-260; GLU-261 AND ASP-262
12.

"Human growth hormone and extracellular domain of its receptor: crystal structure of the complex."
de Vos A.M. , Ultsch M. , Kossiakoff A.A.
Science255:306-312(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 19-254 IN COMPLEX WITH GROWTH HORMONE
13.

"Crystal structure of an antagonist mutant of human growth hormone, G120R, in complex with its receptor at 2.9-A resolution."
Sundstroem M. , Lundqvist T. , Roedin J. , Giebel L.B. , Milligan D. , Norstedt G.
J. Biol. Chem.271:32197-32203(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) OF 19-256 IN COMPLEX WITH GROWTH HORMONE
14.

"Laron dwarfism and mutations of the growth hormone-receptor gene."
Amselem S. , Duquesnoy P. , Attree O. , Novelli G. , Bousnina S. , Postel-Vinay M.-C. , Goossens M.
N. Engl. J. Med.321:989-995(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LARS SER-114
15.

"Amino acid substitutions in the intracellular part of the growth hormone receptor in a patient with the Laron syndrome."
Kou K. , Lajara R. , Rotwein P.
J. Clin. Endocrinol. Metab.76:54-59(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LARS PHE-440
16.

"Spectrum of growth hormone receptor mutations and associated haplotypes in Laron syndrome."
Amselem S. , Duquesnoy P. , Duriez B. , Dastot F. , Sobrier M.-L. , Valleix S. , Goossens M.
Hum. Mol. Genet.2:355-359(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LARS LYS-89; GLN-149; ASP-162; CYS-179 AND GLY-229
17.

"Lack of hormone binding in COS-7 cells expressing a mutated growth hormone receptor found in Laron dwarfism."
Edery M. , Rozakis-Adcock M. , Goujon L. , Finidori J. , Levi-Meyrueis C. , Paly J. , Djiane J. , Postel-Vinay M.-C. , Kelly P.A.
J. Clin. Invest.91:838-844(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT LARS SER-114
18.

"A single amino acid substitution in the exoplasmic domain of the human growth hormone (GH) receptor confers familial GH resistance (Laron syndrome) with positive GH-binding activity by abolishing receptor homodimerization."
Duquesnoy P. , Sobrier M.-L. , Duriez B. , Dastot F. , Buchanan C.R. , Savage M.O. , Preece M.A. , Craescu C.T. , Blouquit Y. , Goossens M. , Amselem S.
EMBO J.13:1386-1395(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LARS HIS-170
19.

"Mutations of the growth hormone receptor in children with idiopathic short stature."
Goddard A.D. , Covello R. , Luoh S.-M. , Clackson T. , Attie K.M. , Gesundheit N. , Rundle A.C. , Wells J.A. , Carlsson L.M.S.
N. Engl. J. Med.333:1093-1098(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS ISSA LYS-62 AND CYS-179;VARIANTS HIS-229 AND ASP-242
20.

"Nine novel growth hormone receptor gene mutations in patients with Laron syndrome."
Sobrier M.-L. , Dastot F. , Duquesnoy P. , Kandemir N. , Yordam N. , Goossens M. , Amselem S.
J. Clin. Endocrinol. Metab.82:435-437(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LARS SER-56; LEU-58 AND ARG-68
21.

"A novel mutation affecting the interdomain link region of the growth hormone receptor in a Vietnamese girl, and response to long-term treatment with recombinant human insulin-like growth factor-I and luteinizing hormone-releasing hormone analogue."
Walker J.L. , Crock P.A. , Behncken S.N. , Rowlinson S.W. , Nicholson L.M. , Boulton T.J.C. , Waters M.J.
J. Clin. Endocrinol. Metab.83:2554-2561(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LARS GLN-149;CHARACTERIZATION OF VARIANT LARS GLN-149
22.

"Growth hormone receptor mutations in children with idiopathic short stature."
Sanchez J.E. , Perera E. , Baumbach L. , Cleveland W.W.
J. Clin. Endocrinol. Metab.83:4079-4083(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ILE-162
23.

"Four contiguous amino acid substitutions, identified in patients with Laron syndrome, differently affect the binding affinity and intracellular trafficking of the growth hormone receptor."
Wojcik J. , Berg M.A. , Esposito N. , Geffner M.E. , Sakati N. , Reiter E.O. , Dower S. , Francke U. , Postel-Vinay M.-C. , Finidori J.
J. Clin. Endocrinol. Metab.83:4481-4489(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LARS HIS-170; THR-171; PRO-172 AND GLY-173;CHARACTERIZATION OF VARIANTS LARS THR-171; PRO-172 AND GLY-173
24.

"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Cargill M. , Altshuler D. , Ireland J. , Sklar P. , Ardlie K. , Patil N. , Shaw N. , Lane C.R. , Lim E.P. , Kalyanaraman N. , Nemesh J. , Ziaugra L. , Friedland L. , Rolfe A. , Warrington J. , Lipshutz R. , Daley G.Q. , Lander E.S.
Nat. Genet.22:231-238(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HIS-179; HIS-229; PHE-440; THR-495; LEU-544 AND THR-579
25.

Cargill M. , Altshuler D. , Ireland J. , Sklar P. , Ardlie K. , Patil N. , Shaw N. , Lane C.R. , Lim E.P. , Kalyanaraman N. , Nemesh J. , Ziaugra L. , Friedland L. , Rolfe A. , Warrington J. , Lipshutz R. , Daley G.Q. , Lander E.S.
Nat. Genet.23:373-373(1999)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
26.

"Characterisation of novel missense mutations in the GH receptor gene causing severe growth retardation."
Enberg B. , Luthman H. , Segnestam K. , Ritzen E.M. , Sundstroem M. , Norstedt G.
Eur. J. Endocrinol.143:71-76(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS LARS CYS-226 AND ASN-262
27.

"Growth hormone receptor variant (L526I) modifies plasma HDL cholesterol phenotype in familial hypercholesterolemia: intra-familial association study in an eight-generation hyperlipidemic kindred."
Takada D. , Ezura Y. , Ono S. , Iino Y. , Katayama Y. , Xin Y. , Wu L.L. , Larringa-Shum S. , Stephenson S.H. , Hunt S.C. , Hopkins P.N. , Emi M.
Am. J. Med. Genet. A121:136-140(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LEU-544
28.

"The first homozygous mutation (S226I) in the highly-conserved WSXWS-like motif of the GH receptor causing Laron syndrome: suppression of GH secretion by GnRH analogue therapy not restored by dihydrotestosterone administration."
Jorge A.A.L. , Souza S.C.A.L. , Arnhold I.J.P. , Mendonca B.B.
Clin. Endocrinol. (Oxf.)60:36-40(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT LARS ILE-244

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