GYPA ELISA Kit for Human(Homo sapiens) | EIAab.comGYPA ELISA Kit for Human(Homo sapiens)

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GYPA (Gene name),

Glycophorin-A (Protein name ), GLPA_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

GYPA(GPA);

Protein name:

Glycophorin-A;

Alternative:

PAS-2;MN sialoglycoprotein;Sialoglycoprotein alpha;

CD:

CD235a;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer. Interacts with Streptococcus gordonii hsa protein.

Function:

Glycophorin A is the major intrinsic membrane protein of the erythrocyte. The N-terminal glycosylated segment, which lies outside the erythrocyte membrane, has MN blood group receptors. Appears to be important for the function of SLC4A1 and is required for high activity of SLC4A1. May be involved in translocation of SLC4A1 to the plasma membrane. Is a receptor for influenza virus. Is a receptor for Plasmodium falciparum erythrocyte-binding antigen 175 (EBA-175); binding of EBA-175 is dependent on sialic acid residues of the O-linked glycans. Appears to be a receptor for Hepatitis A virus (HAV).

Subcellular Location:

Cell membrane Single-pass type I membrane protein Appears to be colocalized with SLC4A1.

Protein Attributes:

Sequence length:

150

Sequence:

50:

100:

150:

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.434973

String:

P02724

Pfam:

PF01102

KEGG:

hsa:2993

MIM:

111300

SMR:

P02724

STRING:

9606.ENSP00000354003

Uniprot:

P02724

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ELISA Kit for Human Glycophorin-A

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E9352m

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96T

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ELISA Kit for Human Glycophorin-A

Cat.:

E9352h

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96T

ELISA Kit for Human Glycophorin-A

Cat.:

E9352d

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96T

ELISA Kit for Human Glycophorin-A

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E9352p

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96T

CLIA Kit for Human Glycophorin-A

Cat.:

U9352p

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96T

CLIA Kit for Human Glycophorin-A

Cat.:

U9352d

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96T

CLIA Kit for Human Glycophorin-A

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U9352m

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96T

CLIA Kit for Human Glycophorin-A

Cat.:

U9352h

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96T

Polyclonal Antibody for Human Glycophorin-A

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P9352Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Glycophorin-A

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P9352Rb-h

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Polyclonal Antibody for Human Glycophorin-A

Monoclonal Antibody for Human Glycophorin-A

Protein for Human Glycophorin-A

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Isolation and characterization of human glycophorin A cDNA clones by a synthetic oligonucleotide approach: nucleotide sequence and mRNA structure."
Siebert P.D. , Fukuda M.
Proc. Natl. Acad. Sci. U.S.A.83:1665-1669(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ALA-13
2.

"Isolation of cDNA clones for human erythrocyte membrane sialoglycoproteins alpha and delta."
Tate C.G. , Tanner M.J.A.
Biochem. J.254:743-750(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS N LEU-20 AND GLU-24
3.

"Structural organization of glycophorin A and B genes: glycophorin B gene evolved by homologous recombination at Alu repeat sequences."
Kudo S. , Fukuda M.
Proc. Natl. Acad. Sci. U.S.A.86:4619-4623(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT ALA-13
4.

"The mechanism of production of multiple mRNAs for human glycophorin A."
Jawad K. , Burness T.H.
Nucleic Acids Res.18:5829-5836(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ALA-13
tissue: Blood.
5.

"Characterization of glycophorin A transcripts: control by the common erythroid-specific promoter and alternative usage of different polyadenylation signals."
Kudo S. , Onda M. , Fukuda M.
J. Biochem.116:183-192(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANT ALA-13
tissue: Blood.
6.

"Extensive alternative splicing of glycophorins in Southeast Asian populations."
Hsu K. , Huang S.-Y. , Chi N. , Lin M.
Submitted (2009-12) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);ALTERNATIVE SPLICING
tissue: Blood.
7.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ALA-13
tissue: Kidney.
8.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANTS N LEU-20 AND GLU-24
9.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANT ALA-13;VARIANTS N LEU-20 AND GLU-24
tissue: Bone marrow.
tissue: Lung.
10.

"Molecular biological study of the structure and expression of human glycophorin A."
Siebert P.D. , Fukuda M.
Rev. Fr. Transfus. Immunohematol.29:251-266(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-145 (ISOFORM 1);VARIANT ALA-13
11.

"Amino-acid sequence and oligosaccharide attachment sites of human erythrocyte glycophorin."
Tomita M. , Marchesi V.T.
Proc. Natl. Acad. Sci. U.S.A.72:2964-2968(1975) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 20-150
12.

Furthmayr H. , Galardy R. , Tomita M. , Marchesi V.T.
Submitted (1977-06) to the PIR data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION TO 81-120
13.

"Characterization of cDNA clones for human glycophorin A. Use for gene localization and for analysis of normal of glycophorin-A-deficient (Finnish type) genomic DNA."
Rahuel C. , London J. , D'Auriol L. , Mattei M.-G. , Tournamille C. , Skrzynia C. , Lebouc Y. , Galibert F. , Cartron J.-P.
Eur. J. Biochem.172:147-153(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 23-150
14.

"Mg and Mc: mutations within the amino-terminal region of glycophorin A."
Furthmayr H. , Metaxas M.N. , Metaxas-Buhler M.
Proc. Natl. Acad. Sci. U.S.A.78:631-635(1981) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE;VARIANT M(C) GLU-24
15.

"Amino acid and carbohydrate structural variants of glycoprotein products (M-N glycoproteins) of the M-N allelic locus."
Blumenfeld O.O. , Adamany A.M. , Puglia K.V.
Proc. Natl. Acad. Sci. U.S.A.78:747-751(1981) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PARTIAL PROTEIN SEQUENCE;VARIANT M(G) ASN-23
16.

"Structural studies on human erythrocyte glycoproteins. Alkali-labile oligosaccharides."
Thomas D.B. , Winzler R.J.
J. Biol. Chem.244:5943-5946(1969) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION
17.

"Erythrocytes deficiency in glycophorin resist invasion by the malarial parasite Plasmodium falciparum."
Pasvol G. , Wainscoat J.S. , Weatherall D.J.
Nature297:64-66(1982) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POLYMORPHISM;INVOLVEMENT IN RESISTANCE TO MALARIA
18.

"Structures of novel sialylated O-linked oligosaccharides isolated from human erythrocyte glycophorins."
Fukuda M. , Lauffenburger M. , Sasaki H. , Rogers M.E. , Dell A.
J. Biol. Chem.262:11952-11957(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION
19.

"The glycophorin A transmembrane domain dimer: sequence-specific propensity for a right-handed supercoil of helices."
Treutlein H.R. , Lemmon M.A. , Engelman D.M. , Brunger A.T.
Biochemistry31:12726-12732(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT
20.

"Glycosylation sites identified by solid-phase Edman degradation: O-linked glycosylation motifs on human glycophorin A."
Pisano A. , Redmond J.W. , Williams K.L. , Gooley A.A.
Glycobiology3:429-435(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT SER-21; THR-22; THR-23; THR-29; SER-30; THR-31; SER-32; THR-36; SER-38; SER-41; THR-44; ASN-45; THR-52; THR-56; SER-63; SER-66 AND THR-69;PARTIAL PROTEIN SEQUENCE
21.

"Receptor and ligand domains for invasion of erythrocytes by Plasmodium falciparum."
Sim B.K. , Chitnis C.E. , Wasniowska K. , Hadley T.J. , Miller L.H.
Science264:1941-1944(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS RECEPTOR FOR PLASMODIUM EBA-175
22.

"Identification of blood group A and B antigens in human glycophorin."
Podbielska M. , Krotkiewski H.
Arch. Immunol. Ther. Exp.48:211-221(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION (AB BLOOD GROUP ANTIGENS)
23.

"Red-cell glycophorin A-band 3 interactions associated with the movement of band 3 to the cell surface."
Young M.T. , Beckmann R. , Toye A.M. , Tanner M.J.
Biochem. J.350:53-60(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF LEU-94; ILE-95; GLY-98 AND GLY-102
24.

"Glycophorin A dimerization and band 3 interaction during erythroid membrane biogenesis: in vivo studies in human glycophorin A transgenic mice."
Auffray I. , Marfatia S. , de Jong K. , Lee G. , Huang C.H. , Paszty C. , Tanner M.J. , Mohandas N. , Chasis J.A.
Blood97:2872-2878(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT
25.

"In vivo detection of hetero-association of glycophorin-A and its mutants within the membrane."
Gerber D. , Shai Y.
J. Biol. Chem.276:31229-31232(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
26.

"Distinct regions of human glycophorin A enhance human red cell anion exchanger (band 3; AE1) transport function and surface trafficking."
Young M.T. , Tanner M.J.
J. Biol. Chem.278:32954-32961(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF PHE-87; SER-88; PRO-90 AND GLU-91
27.

"The blood group system."
Reid M.E. , Christine Lomas-Francis C.

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW;VARIANTS
28.

"ABH blood group antigens in O-glycans of human glycophorin A."
Podbielska M. , Fredriksson S.A. , Nilsson B. , Lisowska E. , Krotkiewski H.
Arch. Biochem. Biophys.429:145-153(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION;IDENTIFICATION BY MASS SPECTROMETRY
29.

"Altered structure and anion transport properties of band 3 (AE1, SLC4A1) in human red cells lacking glycophorin A."
Bruce L.J. , Pan R.J. , Cope D.L. , Uchikawa M. , Gunn R.B. , Cherry R.J. , Tanner M.J.
J. Biol. Chem.279:2414-2420(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
30.

"Capsid region involved in hepatitis A virus binding to glycophorin A of the erythrocyte membrane."
Sanchez G. , Aragones L. , Costafreda M.I. , Ribes E. , Bosch A. , Pinto R.M.
J. Virol.78:9807-9813(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS RECEPTOR FOR FOR HEPATITIS A VIRUS
31.

"Hsa, an adhesin of Streptococcus gordonii DL1, binds to alpha2-3-linked sialic acid on glycophorin A of the erythrocyte membrane."
Yajima A. , Urano-Tashiro Y. , Shimazu K. , Takashima E. , Takahashi Y. , Konishi K.
Microbiol. Immunol.52:69-77(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH STREPTOCOCCUS GORDONII HSA PROTEIN
32.

"Interaction of anion exchanger 1 and glycophorin A in human erythroleukaemic K562 cells."
Pang A.J. , Reithmeier R.A.
Biochem. J.421:345-356(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
33.

"One- and two-dimensional NMR studies of the N-terminal portion of glycophorin A at 11.7 Tesla."
Dill K. , Hu S.H. , Berman E. , Pavia A.A. , Lacombe J.M.
J. Protein Chem.9:129-136(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR
34.

"A transmembrane helix dimer: structure and implications."
Mackenzie K.R. , Prestegard J.H. , Engelman D.M.
Science276:131-133(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 81-120
35.

"Improved prediction for the structure of the dimeric transmembrane domain of glycophorin A obtained through global searching."
Adams P.D. , Engelman D.M. , Bruenger A.T.
Proteins26:257-261(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: 3D-STRUCTURE MODELING OF 93-110
36.

"Molecular basis for the human erythrocyte glycophorin specifying the Miltenberger class I (MiI) phenotype."
Huang C.-H. , Spruell P. , Moulds J.J. , Blumenfeld O.O.
Blood80:257-263(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ENEH/VW MET-47
37.

"Molecular analysis of human glycophorin MiIX gene shows a silent segment transfer and untemplated mutation resulting from gene conversion via sequence repeats."
Huang C.H. , Skov F. , Daniels G. , Tippett P. , Blumenfeld O.O.
Blood80:2379-2387(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ENEH/HUT ANTIGEN LYS-47
38.

"Alteration of splice site selection by an exon mutation in the human glycophorin A gene."
Huang C.H. , Reid M. , Daniels G. , Blumenfeld O.O.
J. Biol. Chem.268:25902-25908(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ERIK ARG-78
39.

"Glycophorin A mutation Ala65 --> Pro gives rise to a novel pair of MNS alleles ENEP (MNS39) and HAG (MNS41) and altered Wrb expression: direct evidence for GPA/band 3 interaction necessary for normal Wrb expression."
Poole J. , Banks J. , Bruce L.J. , Ring S.M. , Levene C. , Stern H. , Overbeeke M.A. , Tanner M.J.
Transfus. Med.9:167-174(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT ENEP/HAG PRO-84
40.

"The low-frequency MNS blood group antigens Ny(a) (MNS18) and Os(a) (MNS38) are associated with GPA amino acid substitutions."
Daniels G.L. , Bruce L.J. , Mawby W.J. , Green C.A. , Petty A. , Okubo Y. , Kornstad L. , Tanner M.J.
Transfusion40:555-559(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS NY(A) GLU-46 AND OS(A) SER-73
41.

"The MNS blood group antigens, Vr (MNS12) and Mt(a) (MNS14), each arise from an amino acid substitution on glycophorin A."
Storry J.R. , Coghlan G. , Poole J. , Figueroa D. , Reid M.E.
Vox Sang.78:52-56(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS VR TYR-66 AND MT(A) ILE-77

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