Protein name:
Glutaredoxin-2, mitochondrial ;
Alternative:
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Monomer; active form. Homodimer; inactive form. The homodimer is probably linked by 1 2Fe-2S cluster.
Function:
Glutathione-dependent oxidoreductase that facilitates the maintenance of mitochondrial redox homeostasis upon induction of apoptosis by oxidative stress. Involved in response to hydrogen peroxide and regulation of apoptosis caused by oxidative stress. Acts as a very efficient catalyst of monothiol reactions because of its high affinity for protein glutathione-mixed disulfides. Can receive electrons not only from glutathione (GSH), but also from thioredoxin reductase supporting both monothiol and dithiol reactions. Efficiently catalyzes both glutathionylation and deglutathionylation of mitochondrial complex I, which in turn regulates the superoxide production by the complex. Overexpression decreases the susceptibility to apoptosis and prevents loss of cardiolipin and cytochrome c release.
Subcellular Location:
Isoform 2
Nucleus
Protein Attributes:
50:
MSWYRAASVG | RRLVASGRIL | AGRRGAAGAA | GSGMGNSTSS | FWGKSATTPV |
100:
NQIQETISNN | CVVIFSKSSC | SYCSMAKKIF | HDMNVNYKVV | ELDMVEYGSQ |
150:
FQEALYKMTG | ERTVPRIFVN | GIFIGGAADT | HRLHKEGKLL | PLVHQCYLNK |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Bovine
Rat
ELISA Kit for Rat Glutaredoxin-2, mitochondrial
ELISA Kit for Rat Glutaredoxin-2, mitochondrial
ELISA Kit for Rat Glutaredoxin-2, mitochondrial
ELISA Kit for Rat Glutaredoxin-2, mitochondrial
CLIA Kit for Rat Glutaredoxin-2, mitochondrial
CLIA Kit for Rat Glutaredoxin-2, mitochondrial
CLIA Kit for Rat Glutaredoxin-2, mitochondrial
CLIA Kit for Rat Glutaredoxin-2, mitochondrial
Polyclonal Antibody for Rat Glutaredoxin-2, mitochondrial
Polyclonal Antibody for Rat Glutaredoxin-2, mitochondrial
Polyclonal Antibody for Rat Glutaredoxin-2, mitochondrial
Polyclonal Antibody for Rat Glutaredoxin-2, mitochondrial
Monoclonal Antibody for Rat Glutaredoxin-2, mitochondrial
Monoclonal Antibody for Rat Glutaredoxin-2, mitochondrial
Monoclonal Antibody for Rat Glutaredoxin-2, mitochondrial
Monoclonal Antibody for Rat Glutaredoxin-2, mitochondrial
Protein for Rat Glutaredoxin-2, mitochondrial
Protein for Rat Glutaredoxin-2, mitochondrial
Protein for Rat Glutaredoxin-2, mitochondrial
Protein for Rat Glutaredoxin-2, mitochondrial
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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more...
Nature428:493-521(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
Brown Norway .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
tissue :
Testis .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : ALTERNATIVE SPLICING (ISOFORMS 1 AND 2)