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Index > Protein center > Glrx3(Gene name) > Mouse
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  • Glrx3 (Gene name),
  • Glutaredoxin-3 (Protein name ),  GLRX3_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Glrx3(Picot;Txnl2);
    Protein name:
    Glutaredoxin-3;
    Alternative:
    PKC-theta-interacting protein(PKCq-interacting protein);PKC-interacting cousin of thioredoxin(PICOT);Thioredoxin-like protein 2;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Monomer and homodimer; the homodimer is probably linked by 2 2Fe-2S clusters that may serve as a redox sensor. The monomer interacts with other proteins. Interacts (via N-terminus) with PRKCQ/PKC-theta (By similarity). Interacts (via C-terminus) with CSRP3. Interacts with CSRP2.
    Function:
    Critical negative regulator of cardiac hypertrophy and a positive inotropic regulator. May play a role in regulating the function of the thioredoxin system. Does not posses any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity. Has an essential function in embryogenesis.
    Subcellular Location:
    Cytoplasm cell cortex Cytoplasm myofibril sarcomere Z line Under the plasma membrane. After PMA stimulation, GLRX3 and PRKCQ/PKC-theta translocate to a more extended submembrane area (By similarity). In the Z line, found associated with CSRP3.
    Protein Attributes:
    Sequence length:
    337
    Sequence:
    50:
    MAAGAAEAGE | AAVAVVEVGS | AQQFEELLRL | KTKSLLVVHF | WAPWAPQCVQ | 
    100:
    MNDVMAELAK | EHPHVSFVKL | EAEAVPEVSE | KYEISSVPTF | LFFKNSQKVD | 
    150:
    RLDGAHAPEL | TKKVQRHVSS | GAFPPSTNEH | LKEDLSLRLK | KLTHAAPCML | 
    200:
    FMKGTPQEPR | CGFSKQMVEI | LHKHNIQFSS | FDIFSDEEVR | QGLKTYSNWP | 
    250:
    TYPQLYVSGE | LIGGLDIIKE | LEASEELDTI | CPKAPKLEER | LKVLTNKASV | 
    300:
    MLFMKGNKQE | AKCGFSKQIL | EILNSTGVEY | ETFDILEDEE | VRQGLKTFSN | 
    337:
    WPTYPQLYVR | GDLVGGLDIV | KELKDNGELL | PILKGEN
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    KEGG:
    UniGene:
    SMR:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Glutaredoxin-3
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    E0509h
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    ELISA Kit for Mouse Glutaredoxin-3
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    E0509r
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    ELISA Kit for Mouse Glutaredoxin-3
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    E0509b
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    CLIA Kit for Mouse Glutaredoxin-3
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    U0509m
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    CLIA Kit for Mouse Glutaredoxin-3
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    U0509h
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    96T
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    CLIA Kit for Mouse Glutaredoxin-3
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    U0509b
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    CLIA Kit for Mouse Glutaredoxin-3
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    U0509r
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    96T
    Polyclonal Antibody for Mouse Glutaredoxin-3
    Cat.:
    P0509Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Mouse Glutaredoxin-3
    Polyclonal Antibody for Mouse Glutaredoxin-3
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    P0509Rb-h
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    Polyclonal Antibody for Mouse Glutaredoxin-3
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    P0509Rb-r
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Mouse Glutaredoxin-3
    Monoclonal Antibody for Mouse Glutaredoxin-3
    Monoclonal Antibody for Mouse Glutaredoxin-3
    Monoclonal Antibody for Mouse Glutaredoxin-3
    Protein for Mouse Glutaredoxin-3
    Protein for Mouse Glutaredoxin-3
    Protein for Mouse Glutaredoxin-3
    Protein for Mouse Glutaredoxin-3

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    References
    1. 1.
      "Inhibition of the c-Jun N-terminal kinase/AP-1 and NF-kappaB pathways by PICOT, a novel protein kinase C-interacting protein with a thioredoxin homology domain."
      Witte S. , Villalba M. , Bi K. , Liu Y. , Isakov N. , Altman A.
      J. Biol. Chem.275:1902-1909(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: C57BL/6J.
      tissue: Embryo.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Embryonic stem cell.
      tissue: Head.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: Czech II.
      tissue: Kidney.
      tissue: Mammary tumor.
    4. 4.
      Lubec G. , Yang J.W. , Zigmond M.
      Submitted (2007-07) to the UniProtKB
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 82-94
      tissue: Brain.
    5. 5.
      "PICOT inhibits cardiac hypertrophy and enhances ventricular function and cardiomyocyte contractility."
      Jeong D. , Cha H. , Kim E. , Kang M. , Yang D.K. , Kim J.M. , Yoon P.O. , Oh J.G. , Bernecker O.Y. , Sakata S. , Le T.T. , Cui L. , Lee Y.H. , Kim do H. , Woo S.H. , Liao R. , Hajjar R.J. , Park W.J.
      Circ. Res.99:307-314(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;OVEREXPRESSION
    6. 6.
      "PICOT attenuates cardiac hypertrophy by disrupting calcineurin-NFAT signaling."
      Jeong D. , Kim J.M. , Cha H. , Oh J.G. , Park J. , Yun S.H. , Ju E.S. , Jeon E.S. , Hajjar R.J. , Park W.J.
      Circ. Res.102:711-719(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;OVEREXPRESSION;INTERACTION WITH CSRP2 AND CSRP3
    7. 7.
      "PICOT is a critical regulator of cardiac hypertrophy and cardiomyocyte contractility."
      Cha H. , Kim J.M. , Oh J.G. , Jeong M.H. , Park C.S. , Park J. , Jeong H.J. , Park B.K. , Lee Y.-H. , Jeong D. , Yang D.K. , Bernecker O.Y. , Kim do H. , Hajjar R.J. , Park W.J.
      J. Mol. Cell. Cardiol.45:796-803(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;DISRUPTION PHENOTYPE
    8. 8.
      "Solution structure of the picot homology 2 domain of the mouse pkc-interacting cousin of thioredoxin protein."
      RIKEN structural genomics initiative (RSGI)
      Submitted (2004-11) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 241-336
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