Gene name:
Glrx3 (Picot;Txnl2) ;
Protein name:
Glutaredoxin-3 ;
Alternative:
PKC-theta-interacting protein (PKCq-interacting protein) ;PKC-interacting cousin of thioredoxin (PICOT) ;Thioredoxin-like protein 2 ;
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
Monomer and homodimer; the homodimer is probably linked by 2 2Fe-2S clusters that may serve as a redox sensor. The monomer interacts with other proteins. Interacts (via N-terminus) with PRKCQ/PKC-theta (By similarity). Interacts (via C-terminus) with CSRP3. Interacts with CSRP2.
Function:
Critical negative regulator of cardiac hypertrophy and a positive inotropic regulator. May play a role in regulating the function of the thioredoxin system. Does not posses any thyoredoxin activity since it lacks the conserved motif that is essential for catalytic activity. Has an essential function in embryogenesis.
Subcellular Location:
Cytoplasm
cell cortex
Cytoplasm
myofibril
sarcomere
Z line
Under the plasma membrane. After PMA stimulation, GLRX3 and PRKCQ/PKC-theta translocate to a more extended submembrane area (By similarity). In the Z line, found associated with CSRP3.
Protein Attributes:
50:
MAAGAAEAGE | AAVAVVEVGS | AQQFEELLRL | KTKSLLVVHF | WAPWAPQCVQ |
100:
MNDVMAELAK | EHPHVSFVKL | EAEAVPEVSE | KYEISSVPTF | LFFKNSQKVD |
150:
RLDGAHAPEL | TKKVQRHVSS | GAFPPSTNEH | LKEDLSLRLK | KLTHAAPCML |
200:
FMKGTPQEPR | CGFSKQMVEI | LHKHNIQFSS | FDIFSDEEVR | QGLKTYSNWP |
250:
TYPQLYVSGE | LIGGLDIIKE | LEASEELDTI | CPKAPKLEER | LKVLTNKASV |
300:
MLFMKGNKQE | AKCGFSKQIL | EILNSTGVEY | ETFDILEDEE | VRQGLKTFSN |
337:
WPTYPQLYVR | GDLVGGLDIV | KELKDNGELL | PILKGEN
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
Bovine
ELISA Kit for Mouse Glutaredoxin-3
ELISA Kit for Mouse Glutaredoxin-3
ELISA Kit for Mouse Glutaredoxin-3
ELISA Kit for Mouse Glutaredoxin-3
CLIA Kit for Mouse Glutaredoxin-3
CLIA Kit for Mouse Glutaredoxin-3
CLIA Kit for Mouse Glutaredoxin-3
CLIA Kit for Mouse Glutaredoxin-3
Polyclonal Antibody for Mouse Glutaredoxin-3
Polyclonal Antibody for Mouse Glutaredoxin-3
Polyclonal Antibody for Mouse Glutaredoxin-3
Polyclonal Antibody for Mouse Glutaredoxin-3
Monoclonal Antibody for Mouse Glutaredoxin-3
Monoclonal Antibody for Mouse Glutaredoxin-3
Monoclonal Antibody for Mouse Glutaredoxin-3
Monoclonal Antibody for Mouse Glutaredoxin-3
Protein for Mouse Glutaredoxin-3
Protein for Mouse Glutaredoxin-3
Protein for Mouse Glutaredoxin-3
Protein for Mouse Glutaredoxin-3
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
C57BL/6J .
tissue :
Embryo .
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more...
Science309:1559-1563(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
tissue :
Embryonic stem cell .
tissue :
Head .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
Czech II .
tissue :
Kidney .
tissue :
Mammary tumor .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PROTEIN SEQUENCE OF 82-94
tissue :
Brain .
5.
"PICOT inhibits cardiac hypertrophy and enhances ventricular function and cardiomyocyte contractility."
Jeong D.
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Cha H.
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Kim E.
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Kang M.
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Circ. Res.99:307-314(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;OVEREXPRESSION
6.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;OVEREXPRESSION;INTERACTION WITH CSRP2 AND CSRP3
7.
"PICOT is a critical regulator of cardiac hypertrophy and cardiomyocyte contractility."
Cha H.
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Kim J.M.
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J. Mol. Cell. Cardiol.45:796-803(2008)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;DISRUPTION PHENOTYPE
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : STRUCTURE BY NMR OF 241-336