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Index > Protein center > GNLY(Gene name) > Human
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  • GNLY (Gene name),
  • Granulysin (Protein name ),  GNLY_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    GNLY(LAG2;NKG5;TLA519);
    Protein name:
    Granulysin;
    Alternative:
    Protein NKG5;Lymphokine LAG-2;T-cell activation protein 519;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Function:
    Antimicrobial protein that kills intracellular pathogens. Active against a broad range of microbes, including Gram-positive and Gram-negative bacteria, fungi, and parasites. Kills Mycobacterium tuberculosis.
    Subcellular Location:
    Secreted Located in the cytotoxic granules of T-cells, which are released upon antigen stimulation.
    Protein Attributes:
    Sequence length:
    145
    Sequence:
    50:
    MATWALLLLA | AMLLGNPGLV | FSRLSPEYYD | LARAHLRDEE | KSCPCLAQEG | 
    100:
    PQGDLLTKTQ | ELGRDYRTCL | TIVQKLKKMV | DKPTQRSVSN | AATRVCRTGR | 
    145:
    SRWRDVCRNF | MRRYQSRVTQ | GLVAGETAQQ | ICEDLRLCIP | STGPL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    KEGG:
    UniGene:
    SMR:
    MIM:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Granulysin
    Cat.:
    E1517h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Granulysin
    Cat.:
    U1517h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human Granulysin
    Cat.:
    P1517Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Granulysin
    Protein for Human Granulysin

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Halleck A. , Ebert L. , Mkoundinya M. , Schick M. , Eisenstein S. , Neubert P. , Kstrang K. , Schatten R. , Shen B. , Henze S. , Mar W. , Korn B. , Zuo D. , Hu Y. , LaBaer J.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    2. 2.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: B-cell.
    3. 3.
      "Granulysin: a novel antimicrobial peptide of cytolytic T lymphocytes and natural killer cells."
      Krensky A.M.
      Biochem. Pharmacol.59:317-320(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
    5. 5.
      "Biosynthesis of granulysin, a novel cytolytic molecule."
      Hanson D.A. , Kaspar A.A. , Poulain F.R. , Krensky A.M.
      Mol. Immunol.36:413-422(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEOLYTIC PROCESSING
    6. 6.
      "Granulysin crystal structure and a structure-derived lytic mechanism."
      Anderson D.H. , Sawaya M.R. , Cascio D. , Ernst W. , Modlin R. , Krensky A. , Eisenberg D.
      J. Mol. Biol.325:355-365(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (0.92 ANGSTROMS) OF 63-136
    7. 7.
      "The isolation and sequence of a novel gene from a human functional T cell line."
      Jongstra J. , Schall T.J. , Dyer B.J. , Clayberger C. , Jorgensen J. , Davis M.M. , Krensky A.M.
      J. Exp. Med.165:601-614(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT);VARIANT ILE-119
    8. 8.
      "A cDNA clone expressed in natural killer and T cells that likely encodes a secreted protein."
      Yabe T. , McSherry C. , Bach F.H. , Houchins J.P.
      J. Exp. Med.172:1159-1163(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM LONG)
    9. 9.
      "Genomic structure of NKG5, a human NK and T cell-specific activation gene."
      Houchins J.P. , Kricek F. , Chujor C.S. , Heise C.P. , Yabe T. , McSherry C. , Bach F.H.
      Immunogenetics37:102-107(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT ILE-119
      tissue: Placenta.
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