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Index > Protein center > GNMT(Gene name) > Human
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  • GNMT (Gene name),
  • Glycine N-methyltransferase (Protein name ),  GNMT_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    GNMT;
    Protein name:
    Glycine N-methyltransferase;
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homotetramer.
    Function:
    Catalyzes the methylation of glycine by using S-adenosylmethionine (AdoMet) to form N-methylglycine (sarcosine) with the concomitant production of S-adenosylhomocysteine (AdoHcy). Possible crucial role in the regulation of tissue concentration of AdoMet and of metabolism of methionine.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    295
    Sequence:
    50:
    MVDSVYRTRS | LGVAAEGLPD | QYADGEAARV | WQLYIGDTRS | RTAEYKAWLL | 
    100:
    GLLRQHGCQR | VLDVACGTGV | DSIMLVEEGF | SVTSVDASDK | MLKYALKERW | 
    150:
    NRRHEPAFDK | WVIEEANWMT | LDKDVPQSAE | GGFDAVICLG | NSFAHLPDCK | 
    200:
    GDQSEHRLAL | KNIASMVRAG | GLLVIDHRNY | DHILSTGCAP | PGKNIYYKSD | 
    250:
    LTKDVTTSVL | IVNNKAHMVT | LDYTVQVPGA | GQDGSPGLSK | FRLSYYPHCL | 
    295:
    ASFTELLQAA | FGGKCQHSVL | GDFKPYKPGQ | TYIPCYFIHV | LKRTD
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    KEGG:
    SMR:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human Glycine N-methyltransferase
    Cat.:
    E12897h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Glycine N-methyltransferase
    MSDS:
    Please sign in first.
    ELISA Kit for Human Glycine N-methyltransferase
    Cat.:
    E12897m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Glycine N-methyltransferase
    Cat.:
    E12897r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    ELISA Kit for Human Glycine N-methyltransferase
    MSDS:
    Please sign in first.
    CLIA Kit for Human Glycine N-methyltransferase
    Cat.:
    U12897h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Glycine N-methyltransferase
    Cat.:
    U12897m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Glycine N-methyltransferase
    Cat.:
    U12897r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human Glycine N-methyltransferase
    MSDS:
    Please sign in first.
    CLIA Kit for Human Glycine N-methyltransferase
    MSDS:
    Please sign in first.
    Polyclonal Antibody for Human Glycine N-methyltransferase
    Polyclonal Antibody for Human Glycine N-methyltransferase
    Polyclonal Antibody for Human Glycine N-methyltransferase
    Polyclonal Antibody for Human Glycine N-methyltransferase
    Cat.:
    P12897Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Glycine N-methyltransferase
    Monoclonal Antibody for Human Glycine N-methyltransferase
    Monoclonal Antibody for Human Glycine N-methyltransferase
    Monoclonal Antibody for Human Glycine N-methyltransferase
    Monoclonal Antibody for Human Glycine N-methyltransferase
    Monoclonal Antibody for Human Glycine N-methyltransferase
    Protein for Human Glycine N-methyltransferase
    Protein for Human Glycine N-methyltransferase
    Protein for Human Glycine N-methyltransferase
    Protein for Human Glycine N-methyltransferase
    Protein for Human Glycine N-methyltransferase

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Characterization of glycine-N-methyltransferase-gene expression in human hepatocellular carcinoma."
      Chen Y.-M.A. , Shiu J.Y. , Tzeng S.J. , Shih L.S. , Chen Y.J. , Lui W.Y. , Chen P.H.
      Int. J. Cancer75:787-793(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Genomic structure, expression, and chromosomal localization of the human glycine N-methyltransferase gene."
      Chen Y.-M.A. , Chen L.-Y. , Wong F.H. , Lee C.M. , Chang T.J. , Yang-Feng T.L.
      Genomics66:43-47(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Placenta.
    3. 3.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Pancreas.
    6. 6.
      "Mammalian glycine N-methyltransferases. Comparative kinetic and structural properties of the enzymes from human, rat, rabbit and pig livers."
      Ogawa H. , Gomi T. , Fujioka M.
      Comp. Biochem. Physiol.106B:601-611(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 31-295
    7. 7.
      "Glycine N-methyltransferases: a comparison of the crystal structures and kinetic properties of recombinant human, mouse and rat enzymes."
      Pakhomova S. , Luka Z. , Grohmann S. , Wagner C. , Newcomer M.E.
      Proteins57:331-337(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.55 ANGSTROMS) OF 2-294;SUBUNIT;FUNCTION
    8. 8.
      "Destabilization of human glycine N-methyltransferase by H176N mutation."
      Luka Z. , Pakhomova S. , Luka Y. , Newcomer M.E. , Wagner C.
      Protein Sci.16:1957-1964(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.7 ANGSTROMS) OF 1-294;SUBUNIT;FUNCTION;CHARACTERIZATION OF VARIANT GNMT DEFICIENCY ASN-177
    9. 9.
      "Mutations in human glycine N-methyltransferase give insights into its role in methionine metabolism."
      Luka Z. , Cerone R. , Phillips J.A. III , Mudd S.H. , Wagner C.
      Hum. Genet.110:68-74(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS GNMT DEFICIENCY PRO-50 AND ASN-177
    10. 10.
      "Effect of naturally occurring mutations in human glycine N-methyltransferase on activity and conformation."
      Luka Z. , Wagner C.
      Biochem. Biophys. Res. Commun.312:1067-1072(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANTS GNMT DEFICIENCY PRO-50; SER-141 AND ASN-177
    11. 11.
      "Glycine N-methyltransferase deficiency: a new patient with a novel mutation."
      Augoustides-Savvopoulou P. , Luka Z. , Karyda S. , Stabler S.P. , Allen R.H. , Patsiaoura K. , Wagner C. , Mudd S.H.
      J. Inherit. Metab. Dis.26:745-759(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT GNMT DEFICIENCY SER-141
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