Gpr143 ELISA Kit for Mouse(Mus musculus) | EIAab.comGpr143 ELISA Kit for Mouse(Mus musculus)

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Gpr143 (Gene name),

G-protein coupled receptor 143 (Protein name ), GP143_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Gpr143(Oa1);

Protein name:

G-protein coupled receptor 143;

Alternative:

Ocular albinism type 1 protein homolog;MOA1;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Interacts with heterotrimeric G(i) proteins. Interacts with ARRB1 and ARRB2. Interacts with MLANA.

Function:

Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport.

Subcellular Location:

Golgi apparatus Melanosome membrane Multi-pass membrane protein Lysosome membrane Multi-pass membrane protein Apical cell membrane Multi-pass membrane protein Distributed throughout the endo-melanosomal system but most of endogenous protein is localized in unpigmented stage II melanosomes. Its expression on the apical cell membrane is sensitive to tyrosine.

Protein Attributes:

Sequence length:

405

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

405:

AQGEL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

10090.ENSMUSP00000026383

KEGG:

mmu:18241

Pfam:

PF02101

String:

P70259

UniGene:

Mm.5157

Uniprot:

P70259

FOR

ELISA Kit for Mouse G-protein coupled receptor 143

CLIA Kit for Mouse G-protein coupled receptor 143

Polyclonal Antibody for Mouse G-protein coupled receptor 143

Monoclonal Antibody for Mouse G-protein coupled receptor 143

Protein for Mouse G-protein coupled receptor 143

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Cloning of the murine homolog of the ocular albinism type 1 (OA1) gene: sequence, genomic structure, and expression analysis in pigment cells."
Bassi M.T. , Incerti B. , Easty D.J. , Sviderskaya E.V. , Ballabio A.
Genome Res.6:880-885(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
strain: 129/Sv.
tissue: Retina.
2.

"Isolation and characterization of a mouse homolog of the X-linked ocular albinism (OA1) gene."
Newton J.M. , Orlow S.J. , Barsh G.S.
Genomics37:219-225(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"The ocular albinism type 1 protein, an intracellular G protein-coupled receptor, regulates melanosome transport in pigment cells."
Palmisano I. , Bagnato P. , Palmigiano A. , Innamorati G. , Rotondo G. , Altimare D. , Venturi C. , Sviderskaya E.V. , Piccirillo R. , Coppola M. , Marigo V. , Incerti B. , Ballabio A. , Surace E.M. , Tacchetti C. , Bennett D.C. , Schiaffino M.V.
Hum. Mol. Genet.17:3487-3501(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION

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