GP1BA ELISA Kit for Human(Homo sapiens) | EIAab.comGP1BA ELISA Kit for Human(Homo sapiens)

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GP1BA (Gene name),

Platelet glycoprotein Ib alpha chain (Protein name ), GP1BA_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

GP1BA;

Protein name:

Platelet glycoprotein Ib alpha chain(GP-Ib alpha;GPIb-alpha;GPIbA;Glycoprotein Ibalpha);

Alternative:

Antigen CD42b-alpha;

CD:

CD42b;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Heterodimer composed of GP-Ib alpha and beta; disulfide linked. GP-IX is complexed with the GP-Ib heterodimer via a non covalent linkage. Interacts with FLNB.

Function:

GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

626

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

600:

626:

RPSALSQGRG | QDLLSTVSIR | YSGHSL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

STRING:

9606.ENSP00000329380

MIM:

153670

UniGene:

Hs.1472

String:

P07359

Pfam:

PF00560

SMR:

P07359

Uniprot:

P07359

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ELISA Kit for Human GP-Ib alpha

Cat.:

E1710m

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Packing:

96T

ELISA Kit for Human GP-Ib alpha

Cat.:

E1710h

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Manual:

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96T

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ELISA Kit for Human GP-Ib alpha

Cat.:

E1710d

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96T

CLIA Kit for Human GP-Ib alpha

Cat.:

U1710h

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Manual:

Looking for manual.

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96T

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CLIA Kit for Human GP-Ib alpha

Cat.:

U1710d

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Packing:

96T

CLIA Kit for Human GP-Ib alpha

Cat.:

U1710m

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Packing:

96T

Polyclonal Antibody for Human GP-Ib alpha

Cat.:

P1710Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human GP-Ib alpha

Cat.:

P1710Rb-h

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human GP-Ib alpha

Protein for Human GP-Ib alpha

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Cloning of the alpha chain of human platelet glycoprotein Ib: a transmembrane protein with homology to leucine-rich alpha 2-glycoprotein."
Lopez J.A. , Chung D.W. , Fujikawa K. , Hagen F.S. , Papayannopoulou T. , Roth G.J.
Proc. Natl. Acad. Sci. U.S.A.84:5615-5619(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE
2.

"Structure of the human blood platelet membrane glycoprotein Ib alpha gene."
Wenger R.H. , Kieffer N. , Wicki A.N. , Clemetson K.J.
Biochem. Biophys. Res. Commun.156:389-395(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"A novel polymorphism, 70Leu/Phe, disrupts a consensus Leu residue within the leucine-rich repeat sequence of platelet glycoprotein Ibalpha."
Matsubara Y. , Murata M. , Moriki T. , Yokoyama K. , Watanabe N. , Nakajima H. , Handa M. , Kawano K. , Aoki N. , Yoshino H. , Ikeda Y.
Thromb. Haemost.87:867-872(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT PHE-86
4.

"Identification of a novel point mutation in platelet glycoprotein Ibalpha, Gly to Ser at residue 233, in a Japanese family with platelet-type von Willebrand disease."
Matsubara Y. , Murata M. , Sugita K. , Ikeda Y.
J. Thromb. Haemost.1:2198-2205(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT VWDP SER-249;CHARACTERIZATION OF VARIANT VWDP VAL-255;MUTAGENESIS OF GLY-249
5.

SeattleSNPs variation discovery resource
Submitted (2001-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT MET-161
6.

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C. , Garber M. , Adams D.J. , Sharpe T. , Harrow J. , Lupski J.R. , Nicholson C. , Searle S.M. , Wilming L. , Young S.K. , Abouelleil A. , Allen N.R. , Bi W. , Bloom T. , Borowsky M.L. , Bugalter B.E. , Butler J. , Chang J.L. , more...
Nature440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Lung.
8.

"Amino acid sequence of the von Willebrand factor-binding domain of platelet membrane glycoprotein Ib."
Titani K. , Takio K. , Handa M. , Ruggeri Z.M.
Proc. Natl. Acad. Sci. U.S.A.84:5610-5614(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 17-315;STRUCTURE OF CARBOHYDRATE
9.

"Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides."
Gevaert K. , Goethals M. , Martens L. , Van Damme J. , Staes A. , Thomas G.R. , Vandekerckhove J.
Nat. Biotechnol.21:566-569(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 128-137
tissue: Platelet.
10.

"StyI polymorphism at nucleotide 1610 in the human platelet glycoprotein Ib alpha gene."
Suzuki K. , Hayashi T. , Akiba J. , Yahagi A. , Tajima K. , Satoh S. , Sasaki H.
Jpn. J. Hum. Genet.41:419-421(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 305-397
11.

"Identification of the disulphide bonds in human platelet glycocalicin."
Hess D. , Schaller J. , Rickli E.E. , Clemetson K.J.
Eur. J. Biochem.199:389-393(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DISULFIDE BONDS
12.

"Human beta-filamin is a new protein that interacts with the cytoplasmic tail of glycoprotein Ibalpha."
Takafuta T. , Wu G. , Murphy G.F. , Shapiro S.S.
J. Biol. Chem.273:17531-17538(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FLNB
tissue: Endothelial cell.
tissue: Placenta.
13.

"Elucidation of N-glycosylation sites on human platelet proteins: a glycoproteomic approach."
Lewandrowski U. , Moebius J. , Walter U. , Sickmann A.
Mol. Cell. Proteomics5:226-233(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-37
tissue: Platelet.
14.

"Glycoprotein Ibalpha forms disulfide bonds with 2 glycoprotein Ibbeta subunits in the resting platelet."
Luo S.Z. , Mo X. , Afshar-Kharghan V. , Srinivasan S. , Lopez J.A. , Li R.
Blood109:603-609(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT;INTERCHAIN DISULFIDE BONDS
15.

"Phosphoproteome of resting human platelets."
Zahedi R.P. , Lewandrowski U. , Wiesner J. , Wortelkamp S. , Moebius J. , Schuetz C. , Walter U. , Gambaryan S. , Sickmann A.
J. Proteome Res.7:526-534(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-629 AND SER-632;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Platelet.
16.

"Crystal structure of the platelet glycoprotein Ibalpha N-terminal domain reveals an unmasking mechanism for receptor activation."
Uff S. , Clemetson J.M. , Harrison T. , Clemetson K.J. , Emsley J.
J. Biol. Chem.277:35657-35663(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.8 ANGSTROMS) OF 17-304;SULFATION AT TYR-292; TYR-294 AND TYR-295
17.

"Structures of glycoprotein Ibalpha and its complex with von Willebrand factor A1 domain."
Huizinga E.G. , Tsuji S. , Romijn R.A. , Schiphorst M.E. , de Groot P.G. , Sixma J.J. , Gros P.
Science297:1176-1179(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.85 ANGSTROMS)
18.

"Molecular modeling of the seven tandem leucine-rich repeats within the ligand-binding region of platelet glycoprotein Ib alpha."
Whisstock J.C. , Shen Y. , Lopez J.A. , Andrews R.K. , Berndt M.C.
Thromb. Haemost.87:329-333(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: 3D-STRUCTURE MODELING OF 52-216
19.

"Genetic and structural characterization of an amino acid dimorphism in glycoprotein Ib alpha involved in platelet transfusion refractoriness."
Murata M. , Furihata K. , Ishida F. , Russell S.R. , Ware J. , Ruggeri Z.M.
Blood79:3086-3090(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SIBA MET-161
20.

"Mutation of leucine-57 to phenylalanine in a platelet glycoprotein Ib alpha leucine tandem repeat occurring in patients with an autosomal dominant variant of Bernard-Soulier disease."
Miller J.L. , Lyle V.A. , Cunningham D.
Blood79:439-446(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BSS PHE-73
21.

"Polymorphism of human glycoprotein Ib alpha results from a variable number of tandem repeats of a 13-amino acid sequence in the mucin-like macroglycopeptide region. Structure/function implications."
Lopez J.A. , Ludwig E.H. , McCarthy B.J.
J. Biol. Chem.267:10055-10061(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POLYMORPHISM OF PRO/THR-RICH DOMAIN
22.

"Point mutation in a leucine-rich repeat of platelet glycoprotein Ib alpha resulting in the Bernard-Soulier syndrome."
Ware J. , Russell S.R. , Marchese P. , Murata M. , Mazzucato M. , de Marco L. , Ruggeri Z.M.
J. Clin. Invest.92:1213-1220(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BSS VAL-172
23.

"Cys209 Ser mutation in the platelet membrane glycoprotein Ib alpha gene is associated with Bernard-Soulier syndrome."
Simsek S. , Noris P. , Lozano M. , Pico M. , von Dem Borne A.E.G.K. , Ribera A. , Gallardo D.
Br. J. Haematol.88:839-844(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BSS SER-225
24.

"Mutation in the gene encoding the alpha chain of platelet glycoprotein Ib in platelet-type von Willebrand disease."
Miller J.L. , Cunningham D. , Lyle V.A. , Finch C.N.
Proc. Natl. Acad. Sci. U.S.A.88:4761-4765(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VWDP VAL-249
25.

"Expression of the phenotypic abnormality of platelet-type von Willebrand disease in a recombinant glycoprotein Ib alpha fragment."
Murata M. , Russell S.R. , Ruggeri Z.M. , Ware J.
J. Clin. Invest.91:2133-2137(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VWDP VAL-249
26.

"Pseudo-von Willebrand disease: a mutation in the platelet glycoprotein Ib alpha gene associated with a hyperactive surface receptor."
Russell S.D. , Roth G.J.
Blood81:1787-1791(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT VWDP VAL-255
27.

"The largest variant of platelet glycoprotein Ib alpha has four tandem repeats of 13 amino acids in the macroglycopeptide region and a genetic linkage with methionine145."
Ishida F. , Furihata K. , Ishida K. , Yan J. , Kitano K. , Kiyosawa K. , Furuta S.
Blood86:1357-1360(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT SIBA MET-161;POLYMORPHISM OF PRO/THR-RICH DOMAIN
28.

"A three-base deletion removing a leucine residue in a leucine-rich repeat of platelet glycoprotein Ib alpha associated with a variant of Bernard-Soulier syndrome (Nancy I)."
de la Salle C. , Baas M.-J. , Lanza F. , Schwartz A. , Hanau D. , Chevalier J. , Gachet C. , Briquel M.-E. , Cazenave J.-P.
Br. J. Haematol.89:386-396(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BSS LEU-195 DEL
29.

"Naturally occurring mutations in glycoprotein Ibalpha that result in defective ligand binding and synthesis of a truncated protein."
Kenny D. , Jonsson O.G. , Morateck P.A. , Montgomery R.R.
Blood92:175-183(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BSS ARG-81
30.

"Characterization of single-nucleotide polymorphisms in coding regions of human genes."
Cargill M. , Altshuler D. , Ireland J. , Sklar P. , Ardlie K. , Patil N. , Shaw N. , Lane C.R. , Lim E.P. , Kalyanaraman N. , Nemesh J. , Ziaugra L. , Friedland L. , Rolfe A. , Warrington J. , Lipshutz R. , Daley G.Q. , Lander E.S.
Nat. Genet.22:231-238(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS HIS-72 AND MET-161
31.

Cargill M. , Altshuler D. , Ireland J. , Sklar P. , Ardlie K. , Patil N. , Shaw N. , Lane C.R. , Lim E.P. , Kalyanaraman N. , Nemesh J. , Ziaugra L. , Friedland L. , Rolfe A. , Warrington J. , Lipshutz R. , Daley G.Q. , Lander E.S.
Nat. Genet.23:373-373(1999)

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
32.

"Molecular characterization of two mutations in platelet glycoprotein (GP) Ib alpha in two Finnish Bernard-Soulier syndrome families."
Koskela S. , Partanen J. , Salmi T.T. , Kekomaki R.
Eur. J. Haematol.62:160-168(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BSS PRO-145
33.

"Autosomal dominant macrothrombocytopenia in Italy is most frequently a type of heterozygous Bernard-Soulier syndrome."
Savoia A. , Balduini C.L. , Savino M. , Noris P. , Del Vecchio M. , Perrotta S. , Belletti S. , Poggi V. , Iolascon A.
Blood97:1330-1335(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BSSA2 VAL-172
34.

"Nonarteritic anterior ischemic optic neuropathy is associated with a specific platelet polymorphism located on the glycoprotein Ibalpha gene."
Salomon O. , Rosenberg N. , Steinberg D.M. , Huna-Baron R. , Moisseiev J. , Dardik R. , Goldan O. , Kurtz S. , Ifrah A. , Seligsohn U.
Ophthalmology111:184-188(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN SUSCEPTIBILITY TO NAION

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