Protein name:
Glypican-3 ;
Alternative:
Intestinal protein OCI-5 ;GTR2-2 ;MXR7 ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Interacts with DPP4.
Function:
Cell surface proteoglycan that bears heparan sulfate. Inhibits the dipeptidyl peptidase activity of DPP4. May be involved in the suppression/modulation of growth in the predominantly mesodermal tissues and organs. May play a role in the modulation of IGF2 interactions with its receptor and thereby modulate its function. May regulate growth and tumor predisposition.
Subcellular Location:
Secreted glypican-3
Secreted
extracellular space
Protein Attributes:
50:
MAGTVRTACL | VVAMLLSLDF | PGQAQPPPPP | PDATCHQVRS | FFQRLQPGLK |
100:
WVPETPVPGS | DLQVCLPKGP | TCCSRKMEEK | YQLTARLNME | QLLQSASMEL |
150:
KFLIIQNAAV | FQEAFEIVVR | HAKNYTNAMF | KNNYPSLTPQ | AFEFVGEFFT |
200:
DVSLYILGSD | INVDDMVNEL | FDSLFPVIYT | QLMNPGLPDS | ALDINECLRG |
250:
ARRDLKVFGN | FPKLIMTQVS | KSLQVTRIFL | QALNLGIEVI | NTTDHLKFSK |
300:
DCGRMLTRMW | YCSYCQGLMM | VKPCGGYCNV | VMQGCMAGVV | EIDKYWREYI |
350:
LSLEELVNGM | YRIYDMENVL | LGLFSTIHDS | IQYVQKNAGK | LTTTIGKLCA |
400:
HSQQRQYRSA | YYPEDLFIDK | KVLKVAHVEH | EETLSSRRRE | LIQKLKSFIS |
450:
FYSALPGYIC | SHSPVAENDT | LCWNGQELVE | RYSQKAARNG | MKNQFNLHEL |
500:
KMKGPEPVVS | QIIDKLKHIN | QLLRTMSMPK | GRVLDKNLDE | EGFESGDCGD |
550:
DEDECIGGSG | DGMIKVKNQL | RFLAELAYDL | DVDDAPGNSQ | QATPKDNEIS |
580:
TFHNLGNVHS | PLKLLTSMAI | SVVCFFFLVH |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Rat
ELISA Kit for Human Glypican-3
ELISA Kit for Human Glypican-3
ELISA Kit for Human Glypican-3
CLIA Kit for Human Glypican-3
CLIA Kit for Human Glypican-3
CLIA Kit for Human Glypican-3
Polyclonal Antibody for Human Glypican-3
Polyclonal Antibody for Human Glypican-3
Polyclonal Antibody for Human Glypican-3
Monoclonal Antibody for Human Glypican-3
Monoclonal Antibody for Human Glypican-3
Monoclonal Antibody for Human Glypican-3
Protein for Human Glypican-3
Protein for Human Glypican-3
Protein for Human Glypican-3
R&D Technical Data
12% SDS-PAGE analysis
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Precision
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Recovery
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Linearity
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Citations
[1].
Hasan O¨ zkan, Harun Erdal, Erdem Koc-ak, Hu¨ seyin Tutkak, Zihni Karaeren,Mustafa Yakut, and Seyfettin Ko¨ klu¨
[2].
Attallah A M, El-Far M, Omran M M, et al.
References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
2.
"Mutations in GPC3, a glypican gene, cause the Simpson-Golabi-Behmel overgrowth syndrome."
Pilia G.
,
Hughes-Benzie R.M.
,
Mackenzie A.
,
Baybayan P.
,
Chen E.Y.
,
Huber R.
,
Neri G.
,
Cao A.
,
Forabosco A.
,
Schlessinger D.
Nat. Genet.12:241-247(1996)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1);DISEASE
tissue :
Embryo .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2 AND 3);VARIANT MET-429
5.
"The DNA sequence of the human X chromosome."
Ross M.T.
,
Grafham D.V.
,
Coffey A.J.
,
Scherer S.
,
McLay K.
,
Muzny D.
,
Platzer M.
,
Howell G.R.
,
Burrows C.
,
Bird C.P.
,
Frankish A.
,
Lovell F.L.
,
Howe K.L.
,
Ashurst J.L.
,
Fulton R.S.
,
Sudbrak R.
,
Wen G.
,
Jones M.C.
,
Hurles M.E.
,
Andrews T.D.
,
Scott C.E.
,
Searle S.
,
Ramser J.
,
Whittaker A.
,
Deadman R.
,
Carter N.P.
,
Hunt S.E.
,
Chen R.
,
Cree A.
,
Gunaratne P.
,
Havlak P.
,
Hodgson A.
,
Metzker M.L.
,
Richards S.
,
Scott G.
,
Steffen D.
,
Sodergren E.
,
Wheeler D.A.
,
Worley K.C.
,
Ainscough R.
,
Ambrose K.D.
,
Ansari-Lari M.A.
,
Aradhya S.
,
Ashwell R.I.
,
Babbage A.K.
,
Bagguley C.L.
,
Ballabio A.
,
Banerjee R.
,
Barker G.E.
,
Barlow K.F.
,
Barrett I.P.
,
Bates K.N.
,
Beare D.M.
,
Beasley H.
,
Beasley O.
,
Beck A.
,
Bethel G.
,
Blechschmidt K.
,
Brady N.
,
Bray-Allen S.
,
Bridgeman A.M.
,
Brown A.J.
,
Brown M.J.
,
Bonnin D.
,
Bruford E.A.
,
Buhay C.
,
Burch P.
,
Burford D.
,
Burgess J.
,
Burrill W.
,
Burton J.
,
Bye J.M.
,
Carder C.
,
Carrel L.
,
Chako J.
,
Chapman J.C.
,
Chavez D.
,
Chen E.
,
Chen G.
,
Chen Y.
,
Chen Z.
,
Chinault C.
,
Ciccodicola A.
,
Clark S.Y.
,
Clarke G.
,
Clee C.M.
,
Clegg S.
,
Clerc-Blankenburg K.
,
Clifford K.
,
Cobley V.
,
Cole C.G.
,
Conquer J.S.
,
Corby N.
,
Connor R.E.
,
David R.
,
Davies J.
,
Davis C.
,
Davis J.
,
Delgado O.
,
Deshazo D.
,
Dhami P.
,
Ding Y.
,
Dinh H.
,
Dodsworth S.
,
Draper H.
,
Dugan-Rocha S.
,
Dunham A.
,
Dunn M.
,
Durbin K.J.
,
Dutta I.
,
Eades T.
,
Ellwood M.
,
Emery-Cohen A.
,
Errington H.
,
Evans K.L.
,
Faulkner L.
,
Francis F.
,
Frankland J.
,
Fraser A.E.
,
Galgoczy P.
,
Gilbert J.
,
Gill R.
,
Gloeckner G.
,
Gregory S.G.
,
Gribble S.
,
Griffiths C.
,
Grocock R.
,
Gu Y.
,
Gwilliam R.
,
Hamilton C.
,
Hart E.A.
,
Hawes A.
,
Heath P.D.
,
Heitmann K.
,
Hennig S.
,
Hernandez J.
,
Hinzmann B.
,
Ho S.
,
Hoffs M.
,
Howden P.J.
,
Huckle E.J.
,
Hume J.
,
Hunt P.J.
,
Hunt A.R.
,
Isherwood J.
,
Jacob L.
,
Johnson D.
,
Jones S.
,
de Jong P.J.
,
Joseph S.S.
,
Keenan S.
,
Kelly S.
,
Kershaw J.K.
,
Khan Z.
,
Kioschis P.
,
Klages S.
,
Knights A.J.
,
Kosiura A.
,
Kovar-Smith C.
,
Laird G.K.
,
Langford C.
,
Lawlor S.
,
Leversha M.
,
Lewis L.
,
Liu W.
,
Lloyd C.
,
Lloyd D.M.
,
Loulseged H.
,
Loveland J.E.
,
Lovell J.D.
,
Lozado R.
,
Lu J.
,
Lyne R.
,
Ma J.
,
Maheshwari M.
,
Matthews L.H.
,
McDowall J.
,
McLaren S.
,
McMurray A.
,
Meidl P.
,
Meitinger T.
,
Milne S.
,
Miner G.
,
Mistry S.L.
,
Morgan M.
,
Morris S.
,
Mueller I.
,
Mullikin J.C.
,
Nguyen N.
,
Nordsiek G.
,
Nyakatura G.
,
O'dell C.N.
,
Okwuonu G.
,
Palmer S.
,
Pandian R.
,
Parker D.
,
Parrish J.
,
Pasternak S.
,
Patel D.
,
Pearce A.V.
,
Pearson D.M.
,
Pelan S.E.
,
Perez L.
,
Porter K.M.
,
Ramsey Y.
,
Reichwald K.
,
Rhodes S.
,
Ridler K.A.
,
Schlessinger D.
,
Schueler M.G.
,
Sehra H.K.
,
Shaw-Smith C.
,
Shen H.
,
Sheridan E.M.
,
Shownkeen R.
,
Skuce C.D.
,
Smith M.L.
,
Sotheran E.C.
,
Steingruber H.E.
,
Steward C.A.
,
Storey R.
,
Swann R.M.
,
Swarbreck D.
,
Tabor P.E.
,
Taudien S.
,
Taylor T.
,
Teague B.
,
Thomas K.
,
Thorpe A.
,
Timms K.
,
Tracey A.
,
Trevanion S.
,
Tromans A.C.
,
d'Urso M.
,
Verduzco D.
,
Villasana D.
,
Waldron L.
,
Wall M.
,
Wang Q.
,
Warren J.
,
Warry G.L.
,
Wei X.
,
West A.
,
Whitehead S.L.
,
Whiteley M.N.
,
Wilkinson J.E.
,
Willey D.L.
,
Williams G.
,
Williams L.
,
Williamson A.
,
Williamson H.
,
Wilming L.
,
Woodmansey R.L.
,
Wray P.W.
,
Yen J.
,
Zhang J.
,
Zhou J.
,
Zoghbi H.
,
Zorilla S.
,
Buck D.
,
Reinhardt R.
,
Poustka A.
,
Rosenthal A.
,
Lehrach H.
,
Meindl A.
,
Minx P.J.
,
Hillier L.W.
,
Willard H.F.
,
Wilson R.K.
,
Waterston R.H.
,
Rice C.M.
,
Vaudin M.
,
Coulson A.
,
Nelson D.L.
,
Weinstock G.
,
Sulston J.E.
,
Durbin R.M.
,
Hubbard T.
,
Gibbs R.A.
,
Beck S.
,
Rogers J.
,
Bentley D.R.
more...
Nature434:325-337(2005)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.
Mural R.J.
,
Istrail S.
,
Sutton G.
,
Florea L.
,
Halpern A.L.
,
Mobarry C.M.
,
Lippert R.
,
Walenz B.
,
Shatkay H.
,
Dew I.
,
Miller J.R.
,
Flanigan M.J.
,
Edwards N.J.
,
Bolanos R.
,
Fasulo D.
,
Halldorsson B.V.
,
Hannenhalli S.
,
Turner R.
,
Yooseph S.
,
Lu F.
,
Nusskern D.R.
,
Shue B.C.
,
Zheng X.H.
,
Zhong F.
,
Delcher A.L.
,
Huson D.H.
,
Kravitz S.A.
,
Mouchard L.
,
Reinert K.
,
Remington K.A.
,
Clark A.G.
,
Waterman M.S.
,
Eichler E.E.
,
Adams M.D.
,
Hunkapiller M.W.
,
Myers E.W.
,
Venter J.C.
more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-58
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : FUNCTION;INTERACTION WITH DPP4
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
10.
"Mutational analysis of the GPC3/GPC4 glypican gene cluster on Xq26 in patients with Simpson-Golabi-Behmel syndrome: identification of loss-of-function mutations in the GPC3 gene."
Veugelers M.
,
Cat B.D.
,
Muyldermans S.Y.
,
Reekmans G.
,
Delande N.
,
Frints S.
,
Legius E.
,
Fryns J.-P.
,
Schrander-Stumpel C.
,
Weidle B.
,
Magdalena N.
,
David G.
Hum. Mol. Genet.9:1321-1328(2000)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT SGBS1 ARG-296