Protein name:
    G-protein coupled receptor family C group 6 member A ;
    
    Alternative:
    
    
    
 
    Organism:
        
        
        
        
        
        
    
        Mouse  (Mus musculus).  
    
 
General Annotation
    Sub Unit:
    Homodimer; disulfide-linked.
    
 
    Function:
    Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca(2+) and Mg(2+). Activated by extracellular calcium and osteocalin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinates nutritionnal and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalents ions and its responsiveness to anabolic steroids.
    
 
    
        
        Subcellular Location:
        
    
     
     
      Cell membrane  
      Multi-pass membrane protein 
     
  
    
 
    
    Protein Attributes:
    
    50:
    MALLITVVTC |  FMIILDTSQS |  CHTPDDFVAI |  TSPGHIMIGG |  LFAIHEKMLS |  
    
 
    100:
    SDDHPRRPQI |  QKCAGFEISV |  FLQTLAMIHS |  IEMINNSTLL |  SGVKLGYEIY |  
    
 
    150:
    DTCTEVTAAM |  AATLRFLSKF |  NCSRETVVFQ |  CDYSSYMPRV |  KAVIGAGYSE |  
    
 
    200:
    TSIAVSRMLN |  LQLMPQVSYE |  STAEILSDKI |  RFPSFLRTVP |  SDFYQTKAMA |  
    
 
    250:
    HLIRQSGWNW |  IGAITTDDDY |  GRLALNTFAI |  QAAENNVCIA |  FKEVLPAFLS |  
    
 
    300:
    DNTIEVRINQ |  TLEKIIAEAQ |  VNVIVVFLRK |  FHVFNLFTKA |  IERKISKIWI |  
    
 
    350:
    ASDNWSTATK |  IITIPNVKKL |  GKVVGFAFRR |  GNTSSFHSFL |  QTLHMYPNDN |  
    
 
    400:
    NKPLHEFAML |  VSACKYIKDG |  DLSQCISNYS |  QATLTYDTTK |  TIENHLFKRN |  
    
 
    450:
    DFLWHYTEPG |  LIYSIQLAVF |  ALGHAIRDLC |  QARDCKKPNA |  FQPWELLAVL |  
    
 
    500:
    KNVTFTDGRN |  SFHFDAHGDL |  NTGYDVVLWK |  ETNGLMTVTK |  MAEYDLQRDV |  
    
 
    550:
    FITTNQETKH |  EFRKLKQILS |  KCSKECSPGQ |  MKKATGSQHS |  CCYECVSCPE |  
    
 
    600:
    NHYSNETDMD |  HCLLCNNETH |  WAPVRSTTCF |  EKEVEYLDWD |  DSLALLLIAL |  
    
 
    650:
    SLLGIAFVLA |  IGIIFTRNLK |  TPVVKSSGGL |  VVCYVMLICH |  ALNFASTGFF |  
    
 
    700:
    IGEPQDFACK |  TRQTLFGVSF |  TLCVSCILTK |  SLKILLAFSF |  DPKLTMFLKC |  
    
 
    750:
    LYRPVPIVLT |  CTGIQVVICT |  LWLVLAAPSV |  EENISLPRVI |  ILECEEGSAL |  
    
 
    800:
    AFGTMLGYIT |  VLAFICFVFA |  FKGRKLPENY |  NEAKFLTFGM |  LIYFIAWITF |  
    
 
    850:
    IPVYTTTFGK |  YLPAVEIIVI |  LISNYGILCC |  IFFPKCYIIL |  CKQKTNTKSA |  
    
 
    900:
    FLQMVYNYSA |  HSVDSLALSH |  VSLDSTSYDT |  ATTNQSPGNK |  MTACQNDNHL |  
    
 
    928:
    PAQVLPHTGT |  AKTIKASKTL |  RQKRSSSI
    
 
      Vaild Sequence:
    
 
Related Databases
Uniprot:
 
 
    
        
        ELISA Kit
         
        
        CLIA Kit
         
        
        Polyclonal Antibody
         
        
        Monoclonal Antibody
         
        
        Protein
         
        
     
FOR
    
        
        Human
         
        
        Rat
         
        
        Bovine
         
        
        Mouse
         
        
     
    
        ELISA Kit for Mouse G-protein coupled receptor family C group 6 member A
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
    
    
    
    
 
    
        ELISA Kit for Mouse G-protein coupled receptor family C group 6 member A
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        ELISA Kit for Mouse G-protein coupled receptor family C group 6 member A
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        ELISA Kit for Mouse G-protein coupled receptor family C group 6 member A
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Mouse G-protein coupled receptor family C group 6 member A
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Mouse G-protein coupled receptor family C group 6 member A
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Mouse G-protein coupled receptor family C group 6 member A
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        CLIA Kit for Mouse G-protein coupled receptor family C group 6 member A
        
     
    
    
    
    
   
    
    
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Mouse G-protein coupled receptor family C group 6 member A
        
     
    
    
    
    
   
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Mouse G-protein coupled receptor family C group 6 member A
        
     
    
    
    
    
   
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Mouse G-protein coupled receptor family C group 6 member A
        
     
    
    
    
    
    
    
 
    
        Polyclonal Antibody for Mouse G-protein coupled receptor family C group 6 member A
        
     
    
    
    
    
   
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Mouse G-protein coupled receptor family C group 6 member A
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Mouse G-protein coupled receptor family C group 6 member A
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Mouse G-protein coupled receptor family C group 6 member A
        
     
    
    
    
    
    
    
 
    
        Monoclonal Antibody for Mouse G-protein coupled receptor family C group 6 member A
        
     
    
    
    
    
    
    
 
    
        Protein for Mouse G-protein coupled receptor family C group 6 member A
        
     
    
    
    
    
    
    
 
    
        Protein for Mouse G-protein coupled receptor family C group 6 member A
        
     
    
    
    
    
    
    
 
    
        Protein for Mouse G-protein coupled receptor family C group 6 member A
        
     
    
    
    
    
    
    
 
    
        Protein for Mouse G-protein coupled receptor family C group 6 member A
        
     
    
    
    
    
    
    
 
 
 
 
 
 
 
 
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    Precision
    
    
    
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    Linearity
    
    
    
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    References
    
    
        
            
        
            
                1.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3);SUBCELLULAR LOCATION;SUBUNIT;GLYCOSYLATION;TISSUE SPECIFICITY 
                    
                    
                    strain :
                    
CD-1 .  
             
         
            
        
            
                2.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [MRNA] 
                    
                    
                    strain :
                    
Swiss Webster / NIH .  
             
         
            
        
            
                3.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] 
                    
                    
                 
             
         
            
        
            
                4.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for FUNCTION 
                    
                    
                 
             
         
            
        
            
                5.
                
                    
                        
                            "Identification of a novel extracellular cation-sensing G-protein-coupled receptor." 
                        
                        
                            Pi M. 
                        ,
                            
Faber P. 
                        ,
                            
Ekema G. 
                        ,
                            
Jackson P.D. 
                        ,
                            
Ting A. 
                        ,
                            
Wang N. 
                        ,
                            
Fontilla-Poole M. 
                        ,
                            
Mays R.W. 
                        ,
                            
Brunden K.R. 
                        ,
                            
Harrington J.J. 
                        ,
                            
Quarles L.D. 
                        
                        
                        
                        
                            J. Biol. Chem.280:40201-40209(2005)
                         
                        
                        
                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for FUNCTION;TISSUE SPECIFICITY 
                    
                    
                 
             
         
            
        
            
                6.
                
                    
                        
                            "GPRC6A null mice exhibit osteopenia, feminization and metabolic syndrome." 
                        
                        
                            Pi M. 
                        ,
                            
Chen L. 
                        ,
                            
Huang M.Z. 
                        ,
                            
Zhu W. 
                        ,
                            
Ringhofer B. 
                        ,
                            
Luo J. 
                        ,
                            
Christenson L. 
                        ,
                            
Li B. 
                        ,
                            
Zhang J. 
                        ,
                            
Jackson P.D. 
                        ,
                            
Faber P. 
                        ,
                            
Brunden K.R. 
                        ,
                            
Harrington J.J. 
                        ,
                            
Quarles L.D. 
                        
                        
                        
                        
                            PLoS ONE3:E3858-E3858(2008)
                         
                        
                        
                        [
PubMed ]
                        [
Europe PMC ]
                        [
Abstract ]
                        
                    
 
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for FUNCTION;DISRUPTION PHENOTYPE 
                    
                    
                 
             
         
            
        
            
                7.
                
                    
                    
                        [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
                        Cited for FUNCTION;DISRUPTION PHENOTYPE