GP6 ELISA Kit for Human(Homo sapiens) | EIAab.comGP6 ELISA Kit for Human(Homo sapiens)

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GP6 (Gene name),

Platelet glycoprotein VI (Protein name ), GPVI_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

GP6;

Protein name:

Platelet glycoprotein VI(GPVI);

Alternative:

Glycoprotein 6;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Associated with Fc receptor gamma chain. The GPVI-FcRgamma complex is associated with the Src kinase family Fyn and Lyn.

Function:

Collagen receptor involved in collagen-induced platelet adhesion and activation. Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely Fyn/Lyn), the adapter protein LAT and leads to the activation of phospholipase C gamma2.

Subcellular Location:

Isoform 2 Cell membrane Single-pass membrane protein

Protein Attributes:

Sequence length:

339

Sequence:

50:

100:

150:

200:

250:

300:

339:

RGRAVQRPLP | PLPPLPLTRK | SNGGQDGGRQ | DVHSRGLCS

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q9HCN6

String:

Q9HCN6

UniGene:

Hs.661752

KEGG:

hsa:51206

STRING:

9606.ENSP00000308782

MIM:

605546

Uniprot:

Q9HCN6

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ELISA Kit for Human GPVI

Cat.:

E2206h

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Packing:

96T

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ELISA Kit for Human GPVI

Cat.:

E2206m

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Manual:

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MSDS:

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Packing:

96T

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CLIA Kit for Human GPVI

Cat.:

U2206h

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Manual:

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MSDS:

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Packing:

96T

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CLIA Kit for Human GPVI

Cat.:

U2206m

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MSDS:

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Packing:

96T

Polyclonal Antibody for Human GPVI

Cat.:

P2206Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human GPVI

Cat.:

P2206Rb-m

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human GPVI

Protein for Human GPVI

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

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References

1.

"Molecular cloning, genomic structure, chromosomal localization, and alternative splice forms of the platelet collagen receptor glycoprotein VI."
Ezumi Y. , Uchiyama T. , Takayama H.
Biochem. Biophys. Res. Commun.277:27-36(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3);PROTEIN SEQUENCE OF 28-41; 62-79 AND 114-142;VARIANTS SER-219; LYS-237; THR-249; GLN-317 AND HIS-322
2.

"Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily."
Jandrot-Perrus M. , Busfield S. , Lagrue A.-H. , Xiong X. , Debili N. , Chickering T. , Le Couedic J.-P. , Goodearl A. , Dussault B. , Fraser C. , Vainchenker W. , Villeval J.-L.
Blood96:1798-1807(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;INTERACTION WITH FC RECEPTOR GAMMA CHAIN;TISSUE SPECIFICITY
tissue: Megakaryocyte.
3.

"Platelet glycoprotein VI."
Miura Y.
Submitted (1999-11) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);VARIANTS SER-219; LYS-237; THR-249; GLN-317 AND HIS-322
4.

"The DNA sequence and biology of human chromosome 19."
Grimwood J. , Gordon L.A. , Olsen A.S. , Terry A. , Schmutz J. , Lamerdin J.E. , Hellsten U. , Goodstein D. , Couronne O. , Tran-Gyamfi M. , Aerts A. , Altherr M. , Ashworth L. , Bajorek E. , Black S. , Branscomb E. , Caenepeel S. , Carrano A.V. , more...
Nature428:529-535(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1);VARIANTS SER-219; LYS-237; THR-249; GLN-317 AND HIS-322
6.

"A novel association of Fc receptor gamma-chain with glycoprotein VI and their co-expression as a collagen receptor in human platelets."
Tsuji M. , Ezumi Y. , Arai M. , Takayama H.
J. Biol. Chem.272:23528-23531(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FC RECEPTOR GAMMA CHAIN
7.

"The influence of N-linked glycosylation on the function of platelet glycoprotein VI."
Kunicki T.J. , Cheli Y. , Moroi M. , Furihata K.
Blood106:2744-2749(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-92;MUTAGENESIS OF ASN-92; SER-94 AND LEU-95
8.

"Gain- and loss-of-function mutants confirm the importance of apical residues to the primary interaction of human glycoprotein VI with collagen."
O'connor M.N. , Smethurst P.A. , Farndale R.W. , Ouwehand W.H.
J. Thromb. Haemost.4:869-873(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: MUTAGENESIS OF LYS-61; LYS-79; ARG-80 AND ARG-186
9.

"Structural basis for platelet collagen responses by the immune-type receptor glycoprotein VI."
Horii K. , Kahn M.L. , Herr A.B.
Blood108:936-942(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 21-203;DISULFIDE BONDS
10.

"Absence of collagen-induced platelet activation caused by compound heterozygous GPVI mutations."
Dumont B. , Lasne D. , Rothschild C. , Bouabdelli M. , Ollivier V. , Oudin C. , Ajzenberg N. , Grandchamp B. , Jandrot-Perrus M.
Blood114:1900-1903(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BDPLT11 CYS-58;CHARACTERIZATION OF VARIANT BDPLT11 CYS-58
11.

"A compound heterozygous mutation in glycoprotein VI in a patient with a bleeding disorder."
Hermans C. , Wittevrongel C. , Thys C. , Smethurst P.A. , Van Geet C. , Freson K.
J. Thromb. Haemost.7:1356-1363(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT BDPLT11 ASN-175;CHARACTERIZATION OF VARIANT BDPLT11 ASN-175

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