GRB7 ELISA Kit for Human(Homo sapiens) | EIAab.comGRB7 ELISA Kit for Human(Homo sapiens) | EIAab.com

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GRB7 (Gene name),

Growth factor receptor-bound protein 7 (Protein name ), GRB7_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

GRB7;

Protein name:

Growth factor receptor-bound protein 7;

Alternative:

Epidermal growth factor receptor GRB-7;B47;GRB7 adapter protein;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer. Interacts (via SH2 domain) with EGFR, ERBB2, ERBB3 (when phosphorylated), ERBB4 (when phosphorylated), EPHB1, INSR, FGFR1 and PDGFRB (when phosphorylated). Interacts with RND1. Interacts (when tyrosine phosphorylated) with FHL2 and HAX1. Interacts (via SH2 domain) with RET and FAK1. Interacts (when not phosphorylated) with ELAVL1. In stressed cells, but not in normal cells, part of a complex that contains at least GRB7, FAK1, STAU1, ELAVL1 and TIA1. Interacts (via SH2 domain) with KIT (phosphorylated).

Function:

Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress.

Subcellular Location:

Cytoplasm Cell junction focal adhesion Cell membrane Peripheral membrane protein Cytoplasmic side Cytoplasmic granule Cell projection Predominantly cytoplasmic. Detected in stress granules, where mRNA is stored under stress conditions.

Protein Attributes:

Sequence length:

532

Sequence:

50:

MELDLSPPHL | SSSPEDLCPA | PGTPPGTPRP | PDTPLPEEVK | RSQPLLIPTT |

100:

GRKLREEERR | ATSLPSIPNP | FPELCSPPSQ | SPILGGPSSA | RGLLPRDASR |

150:

PHVVKVYSED | GACRSVEVAA | GATARHVCEM | LVQRAHALSD | ETWGLVECHP |

200:

HLALERGLED | HESVVEVQAA | WPVGGDSRFV | FRKNFAKYEL | FKSSPHSLFP |

250:

EKMVSSCLDA | HTGISHEDLI | QNFLNAGSFP | EIQGFLQLRG | SGRKLWKRFF |

300:

CFLRRSGLYY | STKGTSKDPR | HLQYVADVNE | SNVYVVTQGR | KLYGMPTDFG |

350:

FCVKPNKLRN | GHKGLRIFCS | EDEQSRTCWL | AAFRLFKYGV | QLYKNYQQAQ |

400:

SRHLHPSCLG | SPPLRSASDN | TLVAMDFSGH | AGRVIENPRE | ALSVALEEAQ |

450:

AWRKKTNHRL | SLPMPASGTS | LSAAIHRTQL | WFHGRISREE | SQRLIGQQGL |

500:

VDGLFLVRES | QRNPQGFVLS | LCHLQKVKHY | LILPSEEEGR | LYFSMDDGQT |

532:

RFTDLLQLVE | FHQLNRGILP | CLLRHCCTRV | AL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

UniGene:

MIM:

Pfam:

STRING:

9606.ENSP00000310771

KEGG:

String:

Uniprot:

FOR

ELISA Kit for Human Growth factor receptor-bound protein 7

ELISA Kit for Human Growth factor receptor-bound protein 7

ELISA Kit for Human Growth factor receptor-bound protein 7

ELISA Kit for Human Growth factor receptor-bound protein 7

CLIA Kit for Human Growth factor receptor-bound protein 7

CLIA Kit for Human Growth factor receptor-bound protein 7

CLIA Kit for Human Growth factor receptor-bound protein 7

CLIA Kit for Human Growth factor receptor-bound protein 7

Polyclonal Antibody for Human Growth factor receptor-bound protein 7

Polyclonal Antibody for Human Growth factor receptor-bound protein 7

Polyclonal Antibody for Human Growth factor receptor-bound protein 7

Polyclonal Antibody for Human Growth factor receptor-bound protein 7

Monoclonal Antibody for Human Growth factor receptor-bound protein 7

Monoclonal Antibody for Human Growth factor receptor-bound protein 7

Monoclonal Antibody for Human Growth factor receptor-bound protein 7

Monoclonal Antibody for Human Growth factor receptor-bound protein 7

Protein for Human Growth factor receptor-bound protein 7

Protein for Human Growth factor receptor-bound protein 7

Protein for Human Growth factor receptor-bound protein 7

Protein for Human Growth factor receptor-bound protein 7

R&D Technical Data

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Precision

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Recovery

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Linearity

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References

1.

"Molecular cloning of human GRB-7 co-amplified with CAB1 and c-ERBB-2 in primary gastric cancer."
Kishi T. , Sasaki H. , Akiyama N. , Ishizuka T. , Sakamoto H. , Aizawa S. , Sugimura T. , Terada M.
Biochem. Biophys. Res. Commun.232:5-9(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue: Esophageal carcinoma.
2.

"A novel variant of human Grb7 is associated with invasive esophageal carcinoma."
Tanaka S. , Mori M. , Akiyoshi T. , Tanaka Y. , Mafune K. , Wands J.R. , Sugimachi K.
J. Clin. Invest.102:821-827(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2)
3.

"Genomic organization and amplification of the human GRB7 gene."
Whittock N.V. , Eady R.A.J. , McGrath J.A.
Submitted (2000-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
4.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
5.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 3 AND 4)
tissue: Ovary.
tissue: Prostate.
tissue: Thalamus.
6.

"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C. , Garber M. , Adams D.J. , Sharpe T. , Harrow J. , Lupski J.R. , Nicholson C. , Searle S.M. , Wilming L. , Young S.K. , Abouelleil A. , Allen N.R. , Bi W. , Bloom T. , Borowsky M.L. , Bugalter B.E. , Butler J. , Chang J.L. , more...
Nature440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Lung.
9.

"Coexpression of Grb7 with epidermal growth factor receptor or Her2/erbB2 in human advanced esophageal carcinoma."
Tanaka S. , Mori M. , Akiyoshi T. , Tanaka Y. , Mafune K. , Wands J.R. , Sugimachi K.
Cancer Res.57:28-31(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 130-343
10.

"Analysis of Grb7 recruitment by heregulin-activated erbB receptors reveals a novel target selectivity for erbB3."
Fiddes R.J. , Campbell D.H. , Janes P.W. , Sivertsen S.P. , Sasaki H. , Wallasch C. , Daly R.J.
J. Biol. Chem.273:7717-7724(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ERBB3 AND ERBB4;SERINE AND THREONINE PHOSPHORYLATION
11.

"Interaction of the Grb7 adapter protein with Rnd1, a new member of the Rho family."
Vayssiere B. , Zalcman G. , Mahe Y. , Mirey G. , Ligensa T. , Weidner K.M. , Chardin P. , Camonis J.
FEBS Lett.467:91-96(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RND1
12.

"Role of Grb7 targeting to focal contacts and its phosphorylation by focal adhesion kinase in regulation of cell migration."
Han D.C. , Shen T.L. , Guan J.L.
J. Biol. Chem.275:28911-28917(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION;SUBCELLULAR LOCATION
13.

"Evidence for an interaction between the insulin receptor and Grb7. A role for two of its binding domains, PIR and SH2."
Kasus-Jacobi A. , Bereziat V. , Perdereau D. , Girard J. , Burnol A.F.
Oncogene19:2052-2059(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH INSR
14.

"Association of Grb7 with phosphoinositides and its role in the regulation of cell migration."
Shen T.L. , Han D.C. , Guan J.L.
J. Biol. Chem.277:29069-29077(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH PTK2/FAK1;MUTAGENESIS OF ARG-239;DOMAIN
15.

"EphB1 associates with Grb7 and regulates cell migration."
Han D.C. , Shen T.L. , Miao H. , Wang B. , Guan J.L.
J. Biol. Chem.277:45655-45661(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;PHOSPHORYLATION;INTERACTION WITH EPHB1
16.

"Signal transduction via the stem cell factor receptor/c-Kit."
Ronnstrand L.
Cell. Mol. Life Sci.61:2535-2548(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON INTERACTION WITH KIT AND ROLE IN KIT SIGNALING
17.

"Signaling by Kit protein-tyrosine kinase--the stem cell factor receptor."
Roskoski R. Jr.
Biochem. Biophys. Res. Commun.337:1-13(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON ROLE IN KIT SIGNALING
18.

"Grb7-SH2 domain dimerisation is affected by a single point mutation."
Porter C.J. , Wilce M.C. , Mackay J.P. , Leedman P. , Wilce J.A.
Eur. Biophys. J.34:454-460(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT;MUTAGENESIS OF PHE-511
19.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-361;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
20.

"Tyrosine phosphorylation of growth factor receptor-bound protein-7 by focal adhesion kinase in the regulation of cell migration, proliferation, and tumorigenesis."
Chu P.Y. , Huang L.Y. , Hsu C.H. , Liang C.C. , Guan J.L. , Hung T.H. , Shen T.L.
J. Biol. Chem.284:20215-20226(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-188 AND TYR-338;INTERACTION WITH PTK2/FAK1
21.

"The cell migration protein Grb7 associates with transcriptional regulator FHL2 in a Grb7 phosphorylation-dependent manner."
Siamakpour-Reihani S. , Argiros H.J. , Wilmeth L.J. , Haas L.L. , Peterson T.A. , Johnson D.L. , Shuster C.B. , Lyons B.A.
J. Mol. Recognit.22:9-17(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH FHL2;STRUCTURE BY NMR;MUTAGENESIS OF TYR-259; TYR-260; TYR-284; TYR-480 AND TYR-492;SUBCELLULAR LOCATION;TYROSINE PHOSPHORYLATION
22.

"EGF-induced Grb7 recruits and promotes Ras activity essential for the tumorigenicity of Sk-Br3 breast cancer cells."
Chu P.Y. , Li T.K. , Ding S.T. , Lai I.R. , Shen T.L.
J. Biol. Chem.285:29279-29285(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBUNIT;PHOSPHORYLATION AT TYR-188 AND TYR-338;MUTAGENESIS OF TYR-188 AND TYR-338
23.

"Grb7 binds to Hax-1 and undergoes an intramolecular domain association that offers a model for Grb7 regulation."
Siamakpour-Reihani S. , Peterson T.A. , Bradford A.M. , Argiros H.J. , Haas L.L. , Lor S.N. , Haulsee Z.M. , Spuches A.M. , Johnson D.L. , Rohrschneider L.R. , Shuster C.B. , Lyons B.A.
J. Mol. Recognit.24:314-321(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HAX1;MUTAGENESIS OF TYR-259; TYR-260; TYR-284; TYR-480 AND TYR-492;CIRCULAR DICHROISM;TYROSINE PHOSPHORYLATION
24.

"Solution structure of the human Grb7-SH2 domain/erbB2 peptide complex and structural basis for Grb7 binding to ErbB2."
Ivancic M. , Daly R.J. , Lyons B.A.
J. Biomol. NMR27:205-219(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 415-532 IN COMPLEX WITH ERBB2;INTERACTION WITH ERBB2
25.

"Solution structure of the RA domain of human GRB7 protein."
RIKEN structural genomics initiative (RSGI)
Submitted (2004-11) to the PDB data bank

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 100-186
26.

"Grb7 SH2 domain structure and interactions with a cyclic peptide inhibitor of cancer cell migration and proliferation."
Porter C.J. , Matthews J.M. , Mackay J.P. , Pursglove S.E. , Schmidberger J.W. , Leedman P.J. , Pero S.C. , Krag D.N. , Wilce M.C. , Wilce J.A.
BMC Struct. Biol.7:58-58(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.1 ANGSTROMS) OF 415-532;INTERACTION WITH THE SYNTHETIC INHIBITOR G7-18NATE;SUBUNIT

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