Grb7 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comGrb7 ELISA Kit for Rat(Rattus norvegicus)

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Grb7 (Gene name),

Growth factor receptor-bound protein 7 (Protein name ), GRB7_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Grb7;

Protein name:

Growth factor receptor-bound protein 7;

Alternative:

GRB7 adapter protein;Epidermal growth factor receptor GRB-7;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Homodimer. Interacts (via SH2 domain) with EGFR, ERBB2, ERBB3 (when phosphorylated), ERBB4 (when phosphorylated), EPHB1, INSR, FGFR1 and PDGFRB (when phosphorylated). Interacts with RND1. Interacts (when tyrosine phosphorylated) with FHL2 and HAX1. Interacts (via SH2 domain) with RET and FAK1. Interacts (when not phosphorylated) with ELAVL1. In stressed cells, but not in normal cells, part of a complex that contains at least GRB7, FAK1, STAU1, ELAVL1 and TIA1. Interacts (via SH2 domain) with KIT (phosphorylated).

Function:

Adapter protein that interacts with the cytoplasmic domain of numerous receptor kinases and modulates down-stream signaling. Promotes activation of down-stream protein kinases, including STAT3, AKT1, MAPK1 and/or MAPK3. Promotes activation of HRAS. Plays a role in signal transduction in response to EGF. Plays a role in the regulation of cell proliferation and cell migration. Plays a role in the assembly and stability of RNA stress granules. Binds to the 5'UTR of target mRNA molecules and represses translation of target mRNA species, when not phosphorylated. Phosphorylation impairs RNA binding and promotes stress granule disassembly during recovery after cellular stress.

Subcellular Location:

Cytoplasm Cell projection Cell junction focal adhesion Cell membrane Peripheral membrane protein Cytoplasmic side Cytoplasmic granule Predominantly cytoplasmic. Detected in stress granules where mRNA is stored under stress conditions.

Protein Attributes:

Sequence length:

535

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

535:

GQTRFTDLLQ | LVEFHQLNRG | ILPCLLRHCC | ARVAL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

Q9QZC5

UniGene:

Rn.28109

STRING:

10116.ENSRNOP00000009299

Pfam:

PF08947

SMR:

Q9QZC5

KEGG:

rno:84427

Uniprot:

Q9QZC5

FOR

ELISA Kit for Rat Growth factor receptor-bound protein 7

CLIA Kit for Rat Growth factor receptor-bound protein 7

Polyclonal Antibody for Rat Growth factor receptor-bound protein 7

Monoclonal Antibody for Rat Growth factor receptor-bound protein 7

Protein for Rat Growth factor receptor-bound protein 7

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Evidence for an interaction between the insulin receptor and Grb7. A role for two of its binding domains, PIR and SH2."
Kasus-Jacobi A. , Bereziat V. , Perdereau D. , Girard J. , Burnol A.F.
Oncogene19:2052-2059(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];INTERACTION WITH INSR; EGFR; FGFR1 AND RET;MUTAGENESIS OF ARG-461;TISSUE SPECIFICITY
tissue: Liver.
2.

Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: Brown Norway.
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Kidney.

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