Gria1 ELISA Kit for Mouse(Mus musculus) | EIAab.comGria1 ELISA Kit for Mouse(Mus musculus)

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Gria1 (Gene name),

Glutamate receptor 1 (Protein name ), GRIA1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Gria1(Glur1);

Protein name:

Glutamate receptor 1(GluR-1);

Alternative:

GluR-A;AMPA-selective glutamate receptor 1;Glutamate receptor ionotropic, AMPA 1(GluA1);GluR-K1;

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. Interacts with DLG1 via its C-terminus. Interacts with CACNG2 (By similarity). Interacts with HIP1 and RASGRF2. Interacts with SYNDIG1 and GRIA2. Interacts with LRFN1 (By similarity). Found in a complex with GRIA2, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with CNIH2, CACNG2 AND CACGN5.

Function:

Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

Subcellular Location:

Cell membrane Multi-pass membrane protein Endoplasmic reticulum membrane Multi-pass membrane protein Cell junction synapse postsynaptic cell membrane Multi-pass membrane protein Cell junction synapse postsynaptic cell membrane postsynaptic density Cell projection dendrite Cell projection dendritic spine Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression.

Protein Attributes:

Sequence length:

907

Sequence:

50:

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907:

PLGATGL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF01094

String:

P23818

KEGG:

mmu:14799

SMR:

P23818

UniGene:

Mm.4920

Uniprot:

P23818

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ELISA Kit for Mouse GluR-1

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E11293m

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96T

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ELISA Kit for Mouse GluR-1

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E11293h

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ELISA Kit for Mouse GluR-1

Cat.:

E11293r

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96T

CLIA Kit for Mouse GluR-1

Cat.:

U11293h

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96T

CLIA Kit for Mouse GluR-1

Cat.:

U11293r

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96T

CLIA Kit for Mouse GluR-1

Cat.:

U11293m

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96T

Polyclonal Antibody for Mouse GluR-1

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P11293Rb-m

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40ug/0.2ml

Polyclonal Antibody for Mouse GluR-1

Cat.:

P11293Rb-h

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40ug/0.2ml

Polyclonal Antibody for Mouse GluR-1

Cat.:

P11293Rb-r

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40ug/0.2ml

Monoclonal Antibody for Mouse GluR-1

Protein for Mouse GluR-1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Functional expression from cloned cDNAs of glutamate receptor species responsive to kainate and quisqualate."
Sakimura K. , Bujo H. , Kushiya E. , Araki K. , Yamazaki M. , Yamazaki M. , Meguro H. , Warashina A. , Numa S. , Mishina M.
FEBS Lett.272:73-80(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"Disruption of the endocytic protein HIP1 results in neurological deficits and decreased AMPA receptor trafficking."
Metzler M. , Li B. , Gan L. , Georgiou J. , Gutekunst C.A. , Wang Y. , Torre E. , Devon R.S. , Oh R. , Legendre-Guillemin V. , Rich M. , Alvarez C. , Gertsenstein M. , McPherson P.S. , Nagy A. , Wang Y.T. , Roder J.C. , Raymond L.A. , more...
EMBO J.22:3254-3266(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HIP1
3.

"Differential regulation of AMPA receptor subunit trafficking by palmitoylation of two distinct sites."
Hayashi T. , Rumbaugh G. , Huganir R.L.
Neuron47:709-723(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PALMITOYLATION AT CYS-603 AND CYS-829
4.

"Age-dependent participation of Ras-GRF proteins in coupling calcium-permeable AMPA glutamate receptors to Ras/Erk signaling in cortical neurons."
Tian X. , Feig L.A.
J. Biol. Chem.281:7578-7582(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RASGRF2
5.

"Direct interaction of post-synaptic density-95/Dlg/ZO-1 domain-containing synaptic molecule Shank3 with GluR1 alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid receptor."
Uchino S. , Wada H. , Honda S. , Nakamura Y. , Ondo Y. , Uchiyama T. , Tsutsumi M. , Suzuki E. , Hirasawa T. , Kohsaka S.
J. Neurochem.97:1203-1214(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SHANK3;MUTAGENESIS OF 905-THR--LEU-907
6.

"SynDIG1: an activity-regulated, AMPA- receptor-interacting transmembrane protein that regulates excitatory synapse development."
Kalashnikova E. , Lorca R.A. , Kaur I. , Barisone G.A. , Li B. , Ishimaru T. , Trimmer J.S. , Mohapatra D.P. , Diaz E.
Neuron65:80-93(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SYNDIG1 AND GRIA2
7.

"Hippocampal AMPA receptor gating controlled by both TARP and cornichon proteins."
Kato A.S. , Gill M.B. , Ho M.T. , Yu H. , Tu Y. , Siuda E.R. , Wang H. , Qian Y.W. , Nisenbaum E.S. , Tomita S. , Bredt D.S.
Neuron68:1082-1096(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
8.

"Loss of sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating glutamate receptor recycling in Down's syndrome."
Wang X. , Zhao Y. , Zhang X. , Badie H. , Zhou Y. , Mu Y. , Loo L.S. , Cai L. , Thompson R.C. , Yang B. , Chen Y. , Johnson P.F. , Wu C. , Bu G. , Mobley W.C. , Zhang D. , Gage F.H. , Ranscht B. , more...
Nat. Med.19:473-480(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SNX27

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