GRIA2 ELISA Kit for Human(Homo sapiens) | EIAab.comGRIA2 ELISA Kit for Human(Homo sapiens)

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GRIA2 (Gene name),

Glutamate receptor 2 (Protein name ), GRIA2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

GRIA2(GLUR2);

Protein name:

Glutamate receptor 2(GluR-2);

Alternative:

GluR-B;AMPA-selective glutamate receptor 2;Glutamate receptor ionotropic, AMPA 2(GluA2);GluR-K2;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers. May interact with MPP4. Forms a ternary complex with GRIP1 and CSPG4. Interacts with PICK1 (via PDZ domain). Interacts with PRKCABP, GRIP1 and GRIP2 (By similarity). Interacts with GRIA1 and SYNDIG1 (By similarity). Interacts with LRFN1 (By similarity). Found in a complex with GRIA1, GRIA3, GRIA4, CNIH2, CNIH3, CACNG2, CACNG3, CACNG4, CACNG5, CACNG7 and CACNG8. Interacts with CACNG5.

Function:

Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. In the presence of CACNG4 or CACNG7 or CACNG8, shows resensitization which is characterized by a delayed accumulation of current flux upon continued application of glutamate.

Subcellular Location:

Cell membrane Multi-pass membrane protein Endoplasmic reticulum membrane Multi-pass membrane protein Cell junction synapse postsynaptic cell membrane Multi-pass membrane protein Interaction with CACNG2, CNIH2 and CNIH3 promotes cell surface expression.

Protein Attributes:

Sequence length:

883

Sequence:

50:

100:

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450:

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600:

650:

700:

750:

800:

850:

883:

NAQNINPSSS | QNSQNFATYK | EGYNVYGIES | VKI

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF01094

SMR:

P42262

MIM:

138247

UniGene:

Hs.32763

String:

P42262

KEGG:

hsa:2891

STRING:

9606.ENSP00000264426

Uniprot:

P42262

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ELISA Kit for Human GluR-2

Cat.:

E11294m

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96T

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ELISA Kit for Human GluR-2

Cat.:

E11294h

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96T

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ELISA Kit for Human GluR-2

Cat.:

E11294r

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CLIA Kit for Human GluR-2

Cat.:

U11294r

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Packing:

96T

CLIA Kit for Human GluR-2

Cat.:

U11294m

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MSDS:

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Packing:

96T

CLIA Kit for Human GluR-2

Cat.:

U11294h

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96T

Polyclonal Antibody for Human GluR-2

Cat.:

P11294Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human GluR-2

Cat.:

P11294Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human GluR-2

Cat.:

P11294Rb-h

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40ug/0.2ml

Monoclonal Antibody for Human GluR-2

Protein for Human GluR-2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Primary structure and functional expression of the AMPA/kainate receptor subunit 2 from human brain."
Sun W. , Ferrer-Montiel A.V. , Montal M.
NeuroReport5:441-444(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM FLIP);VARIANT ARG-607
tissue: Brain.
2.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
3.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS FLOP AND 4);VARIANTS ARG-607 AND ARG-608
tissue: Brain.
4.

"RNA editing of the glutamate receptor subunits GluR2 and GluR6 in human brain tissue."
Paschen W. , Hedreen J.C. , Ross C.A.
J. Neurochem.63:1596-1602(1994) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: RNA EDITING OF POSITION 607
5.

"Glutamatergic plasticity by synaptic delivery of GluR-B(long)-containing AMPA receptors."
Kolleker A. , Zhu J.J. , Schupp B.J. , Qin Y. , Mack V. , Borchardt T. , Koehr G. , Malinow R. , Seeburg P.H. , Osten P.
Neuron40:1199-1212(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION (ISOFORM 3)
6.

"The PDZ domain of PICK1 differentially accepts protein kinase C-alpha and GluR2 as interacting ligands."
Dev K.K. , Nakanishi S. , Henley J.M.
J. Biol. Chem.279:41393-41397(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PICK1
7.

"A eukaryotic specific transmembrane segment is required for tetramerization in AMPA receptors."
Salussolia C.L. , Gan Q. , Kazi R. , Singh P. , Allopenna J. , Furukawa H. , Wollmuth L.P.
J. Neurosci.33:9840-9845(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT;SUBCELLULAR LOCATION
8.

"Crystal structure of the GluR2 amino-terminal domain provides insights into the architecture and assembly of ionotropic glutamate receptors."
Clayton A. , Siebold C. , Gilbert R.J. , Sutton G.C. , Harlos K. , McIlhinney R.A. , Jones E.Y. , Aricescu A.R.
J. Mol. Biol.392:1125-1132(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 25-412;SUBUNIT;DISULFIDE BOND;GLYCOSYLATION AT ASN-370
9.

"Discovery of N-[(2S)-5-(6-fluoro-3-pyridinyl)-2,3-dihydro-1H-inden-2-yl]-2-propanesulfonamide, a novel clinical AMPA receptor positive modulator."
Ward S.E. , Harries M. , Aldegheri L. , Andreotti D. , Ballantine S. , Bax B.D. , Harris A.J. , Harker A.J. , Lund J. , Melarange R. , Mingardi A. , Mookherjee C. , Mosley J. , Neve M. , Oliosi B. , Profeta R. , Smith K.J. , Smith P.W. , more...
J. Med. Chem.53:5801-5812(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.80 ANGSTROMS) OF 413-795 IN COMPLEX WITH GLUTAMATE AND SYNTHETIC INHIBITOR;FUNCTION
10.

"Quinazolinedione sulfonamides: a novel class of competitive AMPA receptor antagonists with oral activity."
Koller M. , Lingenhoehl K. , Schmutz M. , Vranesic I.T. , Kallen J. , Auberson Y.P. , Carcache D.A. , Mattes H. , Ofner S. , Orain D. , Urwyler S.
Bioorg. Med. Chem. Lett.21:3358-3361(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.10 ANGSTROMS) OF 413-796 IN COMPLEX WITH GLUTAMATE AND SYNTHETIC INHIBITOR;DISULFIDE BOND

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