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Index > Protein center > GRIK2(Gene name) > Human
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  • GRIK2 (Gene name),
  • Glutamate receptor, ionotropic kainate 2 (Protein name ),  GRIK2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    GRIK2(GLUR6);
    Protein name:
    Glutamate receptor, ionotropic kainate 2(GluK2);
    Alternative:
    Glutamate receptor 6(GluR-6;GluR6);Excitatory amino acid receptor 4(EAA4);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers (Probable). Assembles into a kainate-gated homomeric channel that does not bind AMPA. GRIK2 associated to GRIK5 forms functional channels that can be gated by AMPA (By similarity). Interacts with DLG4. Interacts with NETO2 (By similarity). Interacts (via C-terminus) with KLHL17 (via kelch repeats); the interaction targets GRIK2 for degradation via ubiquitin-proteasome pathway.
    Function:
    Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2.
    Subcellular Location:
    Cell membrane Multi-pass membrane protein Cell junction synapse postsynaptic cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    908
    Sequence:
    50:
    MKIIFPILSN | PVFRRTVKLL | LCLLWIGYSQ | GTTHVLRFGG | IFEYVESGPM | 
    100:
    GAEELAFRFA | VNTINRNRTL | LPNTTLTYDT | QKINLYDSFE | ASKKACDQLS | 
    150:
    LGVAAIFGPS | HSSSANAVQS | ICNALGVPHI | QTRWKHQVSD | NKDSFYVSLY | 
    200:
    PDFSSLSRAI | LDLVQFFKWK | TVTVVYDDST | GLIRLQELIK | APSRYNLRLK | 
    250:
    IRQLPADTKD | AKPLLKEMKR | GKEFHVIFDC | SHEMAAGILK | QALAMGMMTE | 
    300:
    YYHYIFTTLD | LFALDVEPYR | YSGVNMTGFR | ILNTENTQVS | SIIEKWSMER | 
    350:
    LQAPPKPDSG | LLDGFMTTDA | ALMYDAVHVV | SVAVQQFPQM | TVSSLQCNRH | 
    400:
    KPWRFGTRFM | SLIKEAHWEG | LTGRITFNKT | NGLRTDFDLD | VISLKEEGLE | 
    450:
    KIGTWDPASG | LNMTESQKGK | PANITDSLSN | RSLIVTTILE | EPYVLFKKSD | 
    500:
    KPLYGNDRFE | GYCIDLLREL | STILGFTYEI | RLVEDGKYGA | QDDANGQWNG | 
    550:
    MVRELIDHKA | DLAVAPLAIT | YVREKVIDFS | KPFMTLGISI | LYRKPNGTNP | 
    600:
    GVFSFLNPLS | PDIWMYILLA | YLGVSCVLFV | IARFSPYEWY | NPHPCNPDSD | 
    650:
    VVENNFTLLN | SFWFGVGALM | QQGSELMPKA | LSTRIVGGIW | WFFTLIIISS | 
    700:
    YTANLAAFLT | VERMESPIDS | ADDLAKQTKI | EYGAVEDGAT | MTFFKKSKIS | 
    750:
    TYDKMWAFMS | SRRQSVLVKS | NEEGIQRVLT | SDYAFLMEST | TIEFVTQRNC | 
    800:
    NLTQIGGLID | SKGYGVGTPM | GSPYRDKITI | AILQLQEEGK | LHMMKEKWWR | 
    850:
    GNGCPEEESK | EASALGVQNI | GGIFIVLAAG | LVLSVFVAVG | EFLYKSKKNA | 
    900:
    QLEKRSFCSA | MVEELRMSLK | CQRRLKHKPQ | APVIVKTEEV | INMHTFNDRR | 
    908:
    LPGKETMA
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    Pfam:
    MIM:
    UniGene:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human GluK2
    ELISA Kit for Human GluK2
    ELISA Kit for Human GluK2
    CLIA Kit for Human GluK2
    CLIA Kit for Human GluK2
    CLIA Kit for Human GluK2
    Polyclonal Antibody for Human GluK2
    Polyclonal Antibody for Human GluK2
    Polyclonal Antibody for Human GluK2
    Monoclonal Antibody for Human GluK2
    Monoclonal Antibody for Human GluK2
    Monoclonal Antibody for Human GluK2
    Protein for Human GluK2
    Protein for Human GluK2
    Protein for Human GluK2

    R&D Technical Data
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    Precision
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    Recovery
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    Linearity
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    References
    1. 1.
      "Functional expression and pharmacological characterization of the human EAA4 (GluR6) glutamate receptor: a kainate selective channel subunit."
      Hoo K.H. , Nutt S.L. , Fletcher E.J. , Elliott C.E. , Korczak B. , Deverill R.M. , Rampersad V. , Fantaske R.P. , Kamboj R.K.
      Recept. Channels2:327-337(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      tissue: Fetal brain.
    2. 2.
      "Human GluR6 kainate receptor (GRIK2): molecular cloning, expression, polymorphism, and chromosomal assignment."
      Paschen W. , Blackstone C.D. , Huganir R.L. , Ross C.A.
      Genomics20:435-440(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      "Myeloid progenitor cell growth and apoptosis involves know and cell-specific ionotropic glutamate receptor."
      Langer A. , Xu D. , Kuehcke K. , Fehse B. , Abdallah S. , Lother H.
      Submitted (2000-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5)
    4. 4.
      "Genomic organization of the human GRIK2 gene and characterization of multiple splicing variants."
      Barbon A. , Vallini I. , Barlati S.
      Gene274:187-197(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4);GENE ORGANIZATION
    5. 5.
      "Novel spliced variants of ionotropic glutamate receptor GluR6 in normal human fibroblast and brain cells are transcribed by tissue specific promoters."
      Zhawar V.K. , Kaur G. , deRiel J.K. , Kaur G.P. , Kandpal R.P. , Athwal R.S.
      Gene459:1-10(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 5; 6 AND 7);ALTERNATIVE SPLICING
      tissue: Brain.
    6. 6.
      "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
      Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "RNA editing of the glutamate receptor subunits GluR2 and GluR6 in human brain tissue."
      Paschen W. , Hedreen J.C. , Ross C.A.
      J. Neurochem.63:1596-1602(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: RNA EDITING OF POSITION 621
    9. 9.
      "RNA editing of human kainate receptor subunits."
      Nutt S.L. , Kamboj R.K.
      NeuroReport5:2625-2629(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: RNA EDITING OF POSITIONS 567; 571 AND 621
      tissue: Brain.
    10. 10.
      "The PDZ1 domain of SAP90. Characterization of structure and binding."
      Piserchio A. , Pellegrini M. , Mehta S. , Blackman S.M. , Garcia E.P. , Marshall J. , Mierke D.F.
      J. Biol. Chem.277:6967-6973(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DLG4
    11. 11.
      "Modification and movement: Phosphorylation and SUMOylation regulate endocytosis of GluK2-containing kainate receptors."
      Wilkinson K.A. , Konopacki F. , Henley J.M.
      Commun. Integr. Biol.5:223-226(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT SER-846 AND SER-868;SUMOYLATION AT LYS-886
    12. 12.
      "Binding and selectivity of the marine toxin neodysiherbaine A and its synthetic analogues to GluK1 and GluK2 kainate receptors."
      Unno M. , Shinohara M. , Takayama K. , Tanaka H. , Teruya K. , Doh-ura K. , Sakai R. , Sasaki M. , Ikeda-Saito M.
      J. Mol. Biol.413:667-683(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 429-806 IN COMPLEX WITH AGONIST
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT [LARGE SCALE ANALYSIS] GLN-187
    14. 14.
      "A defect in the ionotropic glutamate receptor 6 gene (GRIK2) is associated with autosomal recessive mental retardation."
      Motazacker M.M. , Rost B.R. , Hucho T. , Garshasbi M. , Kahrizi K. , Ullmann R. , Abedini S.S. , Nieh S.E. , Amini S.H. , Goswami C. , Tzschach A. , Jensen L.R. , Schmitz D. , Ropers H.H. , Najmabadi H. , Kuss A.W.
      Am. J. Hum. Genet.81:792-798(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN MRT6
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