Protein name:
Glutamate receptor, ionotropic kainate 2 (GluK2) ;
Alternative:
Glutamate receptor 6 (GluR-6;GluR6) ;Excitatory amino acid receptor 4 (EAA4) ;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers (Probable). Assembles into a kainate-gated homomeric channel that does not bind AMPA. GRIK2 associated to GRIK5 forms functional channels that can be gated by AMPA (By similarity). Interacts with DLG4. Interacts with NETO2 (By similarity). Interacts (via C-terminus) with KLHL17 (via kelch repeats); the interaction targets GRIK2 for degradation via ubiquitin-proteasome pathway.
Function:
Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2.
Subcellular Location:
Cell membrane
Multi-pass membrane protein
Cell junction
synapse
postsynaptic cell membrane
Multi-pass membrane protein
Protein Attributes:
50:
MKIIFPILSN | PVFRRTVKLL | LCLLWIGYSQ | GTTHVLRFGG | IFEYVESGPM |
100:
GAEELAFRFA | VNTINRNRTL | LPNTTLTYDT | QKINLYDSFE | ASKKACDQLS |
150:
LGVAAIFGPS | HSSSANAVQS | ICNALGVPHI | QTRWKHQVSD | NKDSFYVSLY |
200:
PDFSSLSRAI | LDLVQFFKWK | TVTVVYDDST | GLIRLQELIK | APSRYNLRLK |
250:
IRQLPADTKD | AKPLLKEMKR | GKEFHVIFDC | SHEMAAGILK | QALAMGMMTE |
300:
YYHYIFTTLD | LFALDVEPYR | YSGVNMTGFR | ILNTENTQVS | SIIEKWSMER |
350:
LQAPPKPDSG | LLDGFMTTDA | ALMYDAVHVV | SVAVQQFPQM | TVSSLQCNRH |
400:
KPWRFGTRFM | SLIKEAHWEG | LTGRITFNKT | NGLRTDFDLD | VISLKEEGLE |
450:
KIGTWDPASG | LNMTESQKGK | PANITDSLSN | RSLIVTTILE | EPYVLFKKSD |
500:
KPLYGNDRFE | GYCIDLLREL | STILGFTYEI | RLVEDGKYGA | QDDANGQWNG |
550:
MVRELIDHKA | DLAVAPLAIT | YVREKVIDFS | KPFMTLGISI | LYRKPNGTNP |
600:
GVFSFLNPLS | PDIWMYILLA | YLGVSCVLFV | IARFSPYEWY | NPHPCNPDSD |
650:
VVENNFTLLN | SFWFGVGALM | QQGSELMPKA | LSTRIVGGIW | WFFTLIIISS |
700:
YTANLAAFLT | VERMESPIDS | ADDLAKQTKI | EYGAVEDGAT | MTFFKKSKIS |
750:
TYDKMWAFMS | SRRQSVLVKS | NEEGIQRVLT | SDYAFLMEST | TIEFVTQRNC |
800:
NLTQIGGLID | SKGYGVGTPM | GSPYRDKITI | AILQLQEEGK | LHMMKEKWWR |
850:
GNGCPEEESK | EASALGVQNI | GGIFIVLAAG | LVLSVFVAVG | EFLYKSKKNA |
900:
QLEKRSFCSA | MVEELRMSLK | CQRRLKHKPQ | APVIVKTEEV | INMHTFNDRR |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Rat
Human
ELISA Kit for Human GluK2
ELISA Kit for Human GluK2
ELISA Kit for Human GluK2
Polyclonal Antibody for Human GluK2
Polyclonal Antibody for Human GluK2
Polyclonal Antibody for Human GluK2
Monoclonal Antibody for Human GluK2
Monoclonal Antibody for Human GluK2
Monoclonal Antibody for Human GluK2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
tissue :
Fetal brain .
2.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5)
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4);GENE ORGANIZATION
5.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2; 5; 6 AND 7);ALTERNATIVE SPLICING
tissue :
Brain .
6.
"The DNA sequence and analysis of human chromosome 6."
Mungall A.J.
,
Palmer S.A.
,
Sims S.K.
,
Edwards C.A.
,
Ashurst J.L.
,
Wilming L.
,
Jones M.C.
,
Horton R.
,
Hunt S.E.
,
Scott C.E.
,
Gilbert J.G.R.
,
Clamp M.E.
,
Bethel G.
,
Milne S.
,
Ainscough R.
,
Almeida J.P.
,
Ambrose K.D.
,
Andrews T.D.
,
Ashwell R.I.S.
,
Babbage A.K.
,
Bagguley C.L.
,
Bailey J.
,
Banerjee R.
,
Barker D.J.
,
Barlow K.F.
,
Bates K.
,
Beare D.M.
,
Beasley H.
,
Beasley O.
,
Bird C.P.
,
Blakey S.E.
,
Bray-Allen S.
,
Brook J.
,
Brown A.J.
,
Brown J.Y.
,
Burford D.C.
,
Burrill W.
,
Burton J.
,
Carder C.
,
Carter N.P.
,
Chapman J.C.
,
Clark S.Y.
,
Clark G.
,
Clee C.M.
,
Clegg S.
,
Cobley V.
,
Collier R.E.
,
Collins J.E.
,
Colman L.K.
,
Corby N.R.
,
Coville G.J.
,
Culley K.M.
,
Dhami P.
,
Davies J.
,
Dunn M.
,
Earthrowl M.E.
,
Ellington A.E.
,
Evans K.A.
,
Faulkner L.
,
Francis M.D.
,
Frankish A.
,
Frankland J.
,
French L.
,
Garner P.
,
Garnett J.
,
Ghori M.J.
,
Gilby L.M.
,
Gillson C.J.
,
Glithero R.J.
,
Grafham D.V.
,
Grant M.
,
Gribble S.
,
Griffiths C.
,
Griffiths M.N.D.
,
Hall R.
,
Halls K.S.
,
Hammond S.
,
Harley J.L.
,
Hart E.A.
,
Heath P.D.
,
Heathcott R.
,
Holmes S.J.
,
Howden P.J.
,
Howe K.L.
,
Howell G.R.
,
Huckle E.
,
Humphray S.J.
,
Humphries M.D.
,
Hunt A.R.
,
Johnson C.M.
,
Joy A.A.
,
Kay M.
,
Keenan S.J.
,
Kimberley A.M.
,
King A.
,
Laird G.K.
,
Langford C.
,
Lawlor S.
,
Leongamornlert D.A.
,
Leversha M.
,
Lloyd C.R.
,
Lloyd D.M.
,
Loveland J.E.
,
Lovell J.
,
Martin S.
,
Mashreghi-Mohammadi M.
,
Maslen G.L.
,
Matthews L.
,
McCann O.T.
,
McLaren S.J.
,
McLay K.
,
McMurray A.
,
Moore M.J.F.
,
Mullikin J.C.
,
Niblett D.
,
Nickerson T.
,
Novik K.L.
,
Oliver K.
,
Overton-Larty E.K.
,
Parker A.
,
Patel R.
,
Pearce A.V.
,
Peck A.I.
,
Phillimore B.J.C.T.
,
Phillips S.
,
Plumb R.W.
,
Porter K.M.
,
Ramsey Y.
,
Ranby S.A.
,
Rice C.M.
,
Ross M.T.
,
Searle S.M.
,
Sehra H.K.
,
Sheridan E.
,
Skuce C.D.
,
Smith S.
,
Smith M.
,
Spraggon L.
,
Squares S.L.
,
Steward C.A.
,
Sycamore N.
,
Tamlyn-Hall G.
,
Tester J.
,
Theaker A.J.
,
Thomas D.W.
,
Thorpe A.
,
Tracey A.
,
Tromans A.
,
Tubby B.
,
Wall M.
,
Wallis J.M.
,
West A.P.
,
White S.S.
,
Whitehead S.L.
,
Whittaker H.
,
Wild A.
,
Willey D.J.
,
Wilmer T.E.
,
Wood J.M.
,
Wray P.W.
,
Wyatt J.C.
,
Young L.
,
Younger R.M.
,
Bentley D.R.
,
Coulson A.
,
Durbin R.M.
,
Hubbard T.
,
Sulston J.E.
,
Dunham I.
,
Rogers J.
,
Beck S.
more...
Nature425:805-811(2003)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
7.
Mural R.J.
,
Istrail S.
,
Sutton G.
,
Florea L.
,
Halpern A.L.
,
Mobarry C.M.
,
Lippert R.
,
Walenz B.
,
Shatkay H.
,
Dew I.
,
Miller J.R.
,
Flanigan M.J.
,
Edwards N.J.
,
Bolanos R.
,
Fasulo D.
,
Halldorsson B.V.
,
Hannenhalli S.
,
Turner R.
,
Yooseph S.
,
Lu F.
,
Nusskern D.R.
,
Shue B.C.
,
Zheng X.H.
,
Zhong F.
,
Delcher A.L.
,
Huson D.H.
,
Kravitz S.A.
,
Mouchard L.
,
Reinert K.
,
Remington K.A.
,
Clark A.G.
,
Waterman M.S.
,
Eichler E.E.
,
Adams M.D.
,
Hunkapiller M.W.
,
Myers E.W.
,
Venter J.C.
more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
8.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : RNA EDITING OF POSITION 621
9.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : RNA EDITING OF POSITIONS 567; 571 AND 621
tissue :
Brain .
10.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INTERACTION WITH DLG4
11.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : PHOSPHORYLATION AT SER-846 AND SER-868;SUMOYLATION AT LYS-886
12.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 429-806 IN COMPLEX WITH AGONIST
13.
"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T.
,
Jones S.
,
Wood L.D.
,
Parsons D.W.
,
Lin J.
,
Barber T.D.
,
Mandelker D.
,
Leary R.J.
,
Ptak J.
,
Silliman N.
,
Szabo S.
,
Buckhaults P.
,
Farrell C.
,
Meeh P.
,
Markowitz S.D.
,
Willis J.
,
Dawson D.
,
Willson J.K.V.
,
Gazdar A.F.
,
Hartigan J.
,
Wu L.
,
Liu C.
,
Parmigiani G.
,
Park B.H.
,
Bachman K.E.
,
Papadopoulos N.
,
Vogelstein B.
,
Kinzler K.W.
,
Velculescu V.E.
more...
Science314:268-274(2006)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : VARIANT [LARGE SCALE ANALYSIS] GLN-187
14.
"A defect in the ionotropic glutamate receptor 6 gene (GRIK2) is associated with autosomal recessive mental retardation."
Motazacker M.M.
,
Rost B.R.
,
Hucho T.
,
Garshasbi M.
,
Kahrizi K.
,
Ullmann R.
,
Abedini S.S.
,
Nieh S.E.
,
Amini S.H.
,
Goswami C.
,
Tzschach A.
,
Jensen L.R.
,
Schmitz D.
,
Ropers H.H.
,
Najmabadi H.
,
Kuss A.W.
Am. J. Hum. Genet.81:792-798(2007)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : INVOLVEMENT IN MRT6