Grik2 ELISA Kit for Rat(Rattus norvegicus) | EIAab.comGrik2 ELISA Kit for Rat(Rattus norvegicus)

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Grik2 (Gene name),

Glutamate receptor, ionotropic kainate 2 (Protein name ), GRIK2_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Grik2(Glur6);

Protein name:

Glutamate receptor, ionotropic kainate 2(GluK2);

Alternative:

Glutamate receptor 6(GluR-6;GluR6);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Homotetramer or heterotetramer of pore-forming glutamate receptor subunits. Tetramers may be formed by the dimerization of dimers (Probable). Assembles into a kainate-gated homomeric channel that does not bind AMPA. GRIK2 associated to GRIK5 forms functional channels that can be gated by AMPA (By similarity). Interacts with DLG4. Interacts with NETO2. Interacts (via C-terminus) with KLHL17 (via kelch repeats); the interaction targets GRIK2 for degradation via ubiquitin-proteasome pathway.

Function:

Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist. May be involved in the transmission of light information from the retina to the hypothalamus. Modulates cell surface expression of NETO2.

Subcellular Location:

Cell membrane Multi-pass membrane protein Cell junction synapse postsynaptic cell membrane Multi-pass membrane protein

Protein Attributes:

Sequence length:

908

Sequence:

50:

100:

150:

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250:

300:

350:

400:

450:

500:

550:

600:

650:

700:

750:

800:

850:

900:

908:

LPGKETMA

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF01094

String:

P42260

SMR:

P42260

KEGG:

rno:54257

UniGene:

Rn.87696

STRING:

10116.ENSRNOP00000000415

Uniprot:

P42260

FOR

ELISA Kit for Rat GluK2

CLIA Kit for Rat GluK2

Polyclonal Antibody for Rat GluK2

Monoclonal Antibody for Rat GluK2

Protein for Rat GluK2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Cloning of a cDNA for a glutamate receptor subunit activated by kainate but not AMPA."
Egebjerg J. , Bettler B. , Hermans-Borgmeyer I. , Heinemann S.F.
Nature351:745-748(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: Sprague-Dawley.
tissue: Brain.
2.

"High-affinity kainate and domoate receptors in rat brain."
Lomeli H. , Wisden W. , Koehler M. , Keinaenen K. , Sommer B. , Seeburg P.H.
FEBS Lett.307:139-143(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Brain.
3.

"Determinants of Ca2+ permeability in both TM1 and TM2 of high affinity kainate receptor channels: diversity by RNA editing."
Koehler M. , Burnashev N. , Sakmann B. , Seeburg P.H.
Neuron10:491-500(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 560-585;RNA EDITING
tissue: Brain.
4.

"The PDZ1 domain of SAP90. Characterization of structure and binding."
Piserchio A. , Pellegrini M. , Mehta S. , Blackman S.M. , Garcia E.P. , Marshall J. , Mierke D.F.
J. Biol. Chem.277:6967-6973(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DLG4
5.

"Actinfilin is a Cul3 substrate adaptor, linking GluR6 kainate receptor subunits to the ubiquitin-proteasome pathway."
Salinas G.D. , Blair L.A. , Needleman L.A. , Gonzales J.D. , Chen Y. , Li M. , Singer J.D. , Marshall J.
J. Biol. Chem.281:40164-40173(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KLHL17;UBIQUITINATION;MUTAGENESIS OF VAL-883 AND ILE-884
6.

"SUMOylation regulates kainate-receptor-mediated synaptic transmission."
Martin S. , Nishimune A. , Mellor J.R. , Henley J.M.
Nature447:321-325(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUMOYLATION AT LYS-886;FUNCTION;SUBCELLULAR LOCATION;MUTAGENESIS OF LYS-886
7.

"A transmembrane accessory subunit that modulates kainate-type glutamate receptors."
Zhang W. , St-Gelais F. , Grabner C.P. , Trinidad J.C. , Sumioka A. , Morimoto-Tomita M. , Kim K.S. , Straub C. , Burlingame A.L. , Howe J.R. , Tomita S.
Neuron61:385-396(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NETO2
8.

"Crystal structures of the GluR5 and GluR6 ligand binding cores: molecular mechanisms underlying kainate receptor selectivity."
Mayer M.L.
Neuron45:539-552(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.65 ANGSTROMS) OF 429-806 IN COMPLEXES WITH GLUTAMATE; KAINATE; METHYLGLUTAMATE AND QUISQUALATE
9.

"Structure of the kainate receptor subunit GluR6 agonist-binding domain complexed with domoic acid."
Nanao M.H. , Green T. , Stern-Bach Y. , Heinemann S.F. , Choe S.
Proc. Natl. Acad. Sci. U.S.A.102:1708-1713(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (3.11 ANGSTROMS) OF 419-819 IN COMPLEX WITH DOMOATE;SUBUNIT;GLYCOSYLATION AT ASN-423 AND ASN-751
10.

"Conformational restriction blocks glutamate receptor desensitization."
Weston M.C. , Schuck P. , Ghosal A. , Rosenmund C. , Mayer M.L.
Nat. Struct. Mol. Biol.13:1120-1127(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.96 ANGSTROMS) OF 663-806;FUNCTION;SUBUNIT
11.

"Structure and assembly mechanism for heteromeric kainate receptors."
Kumar J. , Schuck P. , Mayer M.L.
Neuron71:319-331(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.91 ANGSTROMS) OF 32-420 IN COMPLEX WITH GRIK5;DISULFIDE BONDS;GLYCOSYLATION AT ASN-67; ASN-378 AND ASN-412;SUBUNIT

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