GRN ELISA Kit for Human(Homo sapiens) | EIAab.comGRN ELISA Kit for Human(Homo sapiens)

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Index > Protein center > GRN(Gene name) > Human

GRN (Gene name),

Granulins (Protein name ), GRN_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

GRN;

Protein name:

Granulins;

Alternative:

Proepithelin(PEPI);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

Granulin-4 promotes proliferation of the epithelial cell line A431 in culture while granulin-3 acts as an antagonist to granulin-4, inhibiting the growth.

Subcellular Location:

Secreted

Protein Attributes:

Sequence length:

593

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

500:

550:

593:

CCADRRHCCP | AGFRCAARGT | KCLRREAPRW | DAPLRDPALR | QLL

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.514220

STRING:

9606.ENSP00000053867

MIM:

138945

Pfam:

PF00396

SMR:

P28799

String:

P28799

KEGG:

hsa:2896

Uniprot:

P28799

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ELISA Kit for Human Granulins

Cat.:

E0137h

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Manual:

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MSDS:

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Packing:

96T

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ELISA Kit for Human Granulins

Cat.:

E0137r

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MSDS:

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Packing:

96T

ELISA Kit for Human Granulins

Cat.:

E0137m

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MSDS:

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Packing:

96T

CLIA Kit for Human Granulins

Cat.:

U0137r

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MSDS:

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Packing:

96T

CLIA Kit for Human Granulins

Cat.:

U0137m

Price:

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MSDS:

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Packing:

96T

CLIA Kit for Human Granulins

Cat.:

U0137h

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Manual:

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MSDS:

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Packing:

96T

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Polyclonal Antibody for Human Granulins

Cat.:

P0137Rb-h

Price:

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Granulins

Cat.:

P0137Rb-m

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Granulins

Cat.:

P0137Rb-r

Price:

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human Granulins

Protein for Human Granulins

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Structure and chromosomal location of the human granulin gene."
Bhandari V. , Bateman A.
Biochem. Biophys. Res. Commun.188:57-63(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];SEQUENCE REVISION
2.

"The epithelin precursor encodes two proteins with opposing activities on epithelial cell growth."
Plowman G.D. , Green J.M. , Neubauer M.G. , Buckley S.D. , McDonald V.L. , Todaro G.J. , Shoyab M.
J. Biol. Chem.267:13073-13078(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Kidney.
3.

"Isolation and sequence of the granulin precursor cDNA from human bone marrow reveals tandem cysteine-rich granulin domains."
Bhandari V. , Palfree R.G.E. , Bateman A.
Proc. Natl. Acad. Sci. U.S.A.89:1715-1719(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PARTIAL PROTEIN SEQUENCE
tissue: Bone marrow.
4.

"PCDGF sequence from lambda phage human Jurkat T cell cDNA library (Clontech)."
Lu R. , Tian C. , Serrero G.
Submitted (2002-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
5.

Yu W. , Gibbs R.A.
Submitted (1998-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.
6.

"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
Submitted (2003-05) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
7.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3)
tissue: Ovary.
8.

Suzuki Y. , Sugano S. , Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S.
Submitted (2005-04) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
tissue: Adipose tissue.
9.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
tissue: Cervix.
tissue: Lung.
11.

"Granulins, a novel class of peptide from leukocytes."
Bateman A. , Belcourt D.R. , Bennett H.P. , Lazure C. , Solomon S.
Biochem. Biophys. Res. Commun.173:1161-1168(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 206-233; 281-336; 364-396 AND 442-447
tissue: Leukocyte.
12.

"Characterisation of UGP and its relationship with beta-core fragment."
Kardana A. , Bagshawe K.D. , Coles B. , Read D. , Taylor M.
Br. J. Cancer67:686-692(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 281-295
13.

"Mutations in progranulin cause tau-negative frontotemporal dementia linked to chromosome 17."
Baker M. , Mackenzie I.R. , Pickering-Brown S.M. , Gass J. , Rademakers R. , Lindholm C. , Snowden J. , Adamson J. , Sadovnick A.D. , Rollinson S. , Cannon A. , Dwosh E. , Neary D. , Melquist S. , Richardson A. , Dickson D. , Berger Z. , Eriksen J. , more...
Nature442:916-919(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN UP-FTD
14.

"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R. , Jiang X. , Sun D. , Han G. , Wang F. , Ye M. , Wang L. , Zou H.
J. Proteome Res.8:651-661(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-265
tissue: Liver.
15.

"Development and application of mass spectrometric methods for the analysis of progranulin N-glycosylation."
Songsrirote K. , Li Z. , Ashford D. , Bateman A. , Thomas-Oates J.
J. Proteomics73:1479-1490(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-118; ASN-265; ASN-368 AND ASN-530
16.

"Strikingly different clinicopathological phenotypes determined by progranulin-mutation dosage."
Smith K.R. , Damiano J. , Franceschetti S. , Carpenter S. , Canafoglia L. , Morbin M. , Rossi G. , Pareyson D. , Mole S.E. , Staropoli J.F. , Sims K.B. , Lewis J. , Lin W.L. , Dickson D.W. , Dahl H.H. , Bahlo M. , Berkovic S.F.
Am. J. Hum. Genet.90:1102-1107(2012) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN CLN11
17.

"Secreted progranulin is a homodimer and is not a component of high density lipoproteins (HDL)."
Nguyen A.D. , Nguyen T.A. , Cenik B. , Yu G. , Herz J. , Walther T.C. , Davidson W.S. , Farese R.V. Jr.
J. Biol. Chem.288:8627-8635(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT
18.

"Design and solution structure of a well-folded stack of two beta-hairpins based on the amino-terminal fragment of human granulin A."
Tolkatchev D. , Ng A. , Vranken W. , Ni F.
Biochemistry39:2878-2886(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 284-311
19.

"Structure dissection of human progranulin identifies well-folded granulin/epithelin modules with unique functional activities."
Tolkatchev D. , Malik S. , Vinogradova A. , Wang P. , Chen Z. , Xu P. , Bennett H.P. , Bateman A. , Ni F.
Protein Sci.17:711-724(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 123-179; 281-337 AND 364-417;DISULFIDE BONDS
20.

"HDDD2 is a familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions caused by a missense mutation in the signal peptide of progranulin."
Mukherjee O. , Pastor P. , Cairns N.J. , Chakraverty S. , Kauwe J.S.K. , Shears S. , Behrens M.I. , Budde J. , Hinrichs A.L. , Norton J. , Levitch D. , Taylor-Reinwald L. , Gitcho M. , Tu P.-H. , Tenenholz Grinberg L. , Liscic R.M. , Armendariz J. , Morris J.C. , more...
Ann. Neurol.60:314-322(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT UP-FTD ASP-9
21.

"Molecular characterization of novel progranulin (GRN) mutations in frontotemporal dementia."
Mukherjee O. , Wang J. , Gitcho M. , Chakraverty S. , Taylor-Reinwald L. , Shears S. , Kauwe J.S.K. , Norton J. , Levitch D. , Bigio E.H. , Hatanpaa K.J. , White C.L. , Morris J.C. , Cairns N.J. , Goate A.
Hum. Mutat.29:512-521(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION OF VARIANT UP-FTD ASP-9
22.

"A thorough assessment of benign genetic variability in GRN and MAPT."
Guerreiro R.J. , Washecka N. , Hardy J. , Singleton A.
Hum. Mutat.31:E1126-E1140(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS TRP-19; TRP-55; THR-69; ASN-119 DEL; TYR-120; MET-182; SER-221; LEU-275; ASN-376; LEU-398; GLN-433; ALA-515 AND HIS-564

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