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Index > Protein center > CXCL1(Gene name) > Human
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  • CXCL1 (Gene name),
  • Growth-regulated alpha protein (Protein name ),  GROA_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    CXCL1(GRO;GRO1;GROA;MGSA;SCYB1);
    Protein name:
    Growth-regulated alpha protein;
    Alternative:
    GRO-alpha(1-73);C-X-C motif chemokine 1;Neutrophil-activating protein 3(NAP-3);Melanoma growth stimulatory activity(MGSA);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Has chemotactic activity for neutrophils. May play a role in inflammation and exerts its effects on endothelial cells in an autocrine fashion. In vitro, the processed forms GRO-alpha(4-73), GRO-alpha(5-73) and GRO-alpha(6-73) show a 30-fold higher chemotactic activity.
    Subcellular Location:
    Secreted
    Protein Attributes:
    Sequence length:
    107
    Sequence:
    50:
    MARAALSAAP | SNPRLLRVAL | LLLLLVAAGR | RAAGASVATE | LRCQCLQTLQ | 
    100:
    GIHPKNIQSV | NVKSPGPHCA | QTEVIATLKN | GRKACLNPAS | PIVKKIIEKM | 
    107:
    LNSDKSN
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    String:
    Pfam:
    MIM:
    SMR:
    KEGG:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human Growth-regulated alpha protein
    Cat.:
    E1210h
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Growth-regulated alpha protein
    Cat.:
    E1210r
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    MSDS:
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    Packing:
    96T
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    ELISA Kit for Human Growth-regulated alpha protein
    Cat.:
    E1210m
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    MSDS:
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    Packing:
    96T
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    CLIA Kit for Human Growth-regulated alpha protein
    Cat.:
    U1210r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Growth-regulated alpha protein
    Cat.:
    U1210h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Growth-regulated alpha protein
    Cat.:
    U1210m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Growth-regulated alpha protein
    Cat.:
    P1210Rb-h
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Growth-regulated alpha protein
    Cat.:
    P1210Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human Growth-regulated alpha protein
    Cat.:
    P1210Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Growth-regulated alpha protein
    Monoclonal Antibody for Human Growth-regulated alpha protein
    Monoclonal Antibody for Human Growth-regulated alpha protein
    Protein for Human Growth-regulated alpha protein
    Protein for Human Growth-regulated alpha protein
    Cat.:
    R1210h
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%
    Protein for Human Growth-regulated alpha protein

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    Linearity
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    References
    1. 1.
      "Constitutive overexpression of a growth-regulated gene in transformed Chinese hamster and human cells."
      Anisowicz A. , Bardwell L. , Sager R.
      Proc. Natl. Acad. Sci. U.S.A.84:7188-7192(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      "Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor structurally related to beta-thromboglobulin."
      Richmond A. , Balentien E. , Thomas H.G. , Flaggs G. , Barton D.E. , Spiess J. , Bordoni R. , Francke U. , Derynck R.
      EMBO J.7:2025-2033(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    3. 3.
      "Nucleotide sequence of the human melanoma growth stimulatory activity (MGSA) gene."
      Baker N.E. , Kucera G. , Richmond A.
      Nucleic Acids Res.18:6453-6453(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
      tissue: Blood.
    4. 4.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Ovary.
    6. 6.
      "Isolation of the CXC chemokines ENA-78, GRO alpha and GRO gamma from tumor cells and leukocytes reveals NH2-terminal heterogeneity. Functional comparison of different natural isoforms."
      Wuyts A. , Govaerts C. , Struyf S. , Lenaerts J.-P. , Put W. , Conings R. , Proost P. , Van Damme J.
      Eur. J. Biochem.260:421-429(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 35-107;IDENTIFICATION OF GRO-ALPHA(4-73); GRO-ALPHA(5-73) AND GRO-ALPHA(6-73);PROTEOLYTIC PROCESSING OF N-TERMINAL;FUNCTION
      tissue: Peripheral blood monocyte.
    7. 7.
      "Lipopolysaccharide-stimulated human monocytes secrete, apart from neutrophil-activating peptide 1/interleukin 8, a second neutrophil-activating protein. NH2-terminal amino acid sequence identity with melanoma growth stimulatory activity."
      Schroeder J.-M. , Persoon N.L.M. , Christophers E.
      J. Exp. Med.171:1091-1100(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 35-65
    8. 8.
      "Inflammatory cytokines induce synthesis and secretion of gro protein and a neutrophil chemotactic factor but not beta 2-microglobulin in human synovial cells and fibroblasts."
      Golds E.E. , Mason P. , Nyirkos P.
      Biochem. J.259:585-588(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 35-57
    9. 9.
      "Biochemical and biological characterization of NAP-1/IL-8-related cytokines in lesional psoriatic scale."
      Schroeder J.-M.
      Adv. Exp. Med. Biol.305:97-107(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 35-51
      tissue: Skin.
    10. 10.
      "Signal peptide prediction based on analysis of experimentally verified cleavage sites."
      Zhang Z. , Henzel W.J.
      Protein Sci.13:2819-2824(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 35-49
    11. 11.
      "Expression and secretion of gro/MGSA by stimulated human endothelial cells."
      Wen D. , Rowland A. , Derynck R.
      EMBO J.8:1761-1766(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: POSSIBLE FUNCTION
    12. 12.
      "1H assignment and secondary structure determination of human melanoma growth stimulating activity (MGSA) by NMR spectroscopy."
      Fairbrother W.J. , Reilly D. , Colby T. , Horuk R.
      FEBS Lett.330:302-306(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR
    13. 13.
      "The solution structure of melanoma growth stimulating activity."
      Fairbrother W.J. , Reilly D. , Colby T. , Hesselgesser J. , Horuk R.
      J. Mol. Biol.242:252-270(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR
    14. 14.
      "Solution structure of GRO/melanoma growth stimulatory activity determined by 1H NMR spectroscopy."
      Kim K.S. , Clark-Lewis I. , Sykes B.D.
      J. Biol. Chem.269:32909-32915(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR
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