Protein name:
Gamma-secretase-activating protein (GSAP) ;
Alternative:
Protein pigeon homolog ;
Organism:
GSAP (Homo sapiens).
General Annotation
Sub Unit:
Interacts with APP; specifically interacts with the CTF-alpha product of APP. Interacts with the gamma-secretase complex.
Function:
Regulator of gamma-secretase activity, which specifically activates the production of beta-amyloid protein (beta-amyloid protein 40 and beta-amyloid protein 42), without affecting the cleavage of other gamma-secretase targets such has Notch. The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Specifically promotes the gamma-cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate beta-amyloid, while it reduces the epsilon-cleavage of APP CTF-alpha, leading to a low production of AICD.
Subcellular Location:
Golgi apparatus
trans-Golgi network
Protein Attributes:
50:
MALRLVADFD | LGKDVLPWLR | AQRAVSEASG | AGSGGADVLE | NDYESLHVLN |
100:
VERNGNIIYT | YKDDKGNVVF | GLYDCQTRQN | ELLYTFEKDL | QVFSCSVNSE |
150:
RTLLAASLVQ | STKEGKRNEL | QPGSKCLTLL | VEIHPVNNVK | VLKAVDSYIW |
200:
VQFLYPHIES | HPLPENHLLL | ISEEKYIEQF | RIHVAQEDGN | RVVIKNSGHL |
250:
PRDRIAEDFV | WAQWDMSEQR | LYYIDLKKSR | SILKCIQFYA | DESYNLMFEV |
300:
PLDISLSNSG | FKLVNFGCDY | HQYRDKFSKH | LTLCVFTNHT | GSLCVCYSPK |
350:
CASWGQITYS | VFYIHKGHSK | TFTTSLENVG | SHMTKGITFL | NLDYYVAVYL |
400:
PGHFFHLLNV | QHPDLICHNL | FLTGNNEMID | MLPHCPLQSL | SGSLVLDCCS |
450:
GKLYRALLSQ | SSLLQLLQNT | CLDCEKMAAL | HCALYCGQGA | QFLEAQIIQW |
500:
ISENVSACHS | FDLIQEFIIA | SSYWSVYSET | SNMDKLLPHS | SVLTWNTEIP |
550:
GITLVTEDIA | LPLMKVLSFK | GYWEKLNSNL | EYVKYAKPHF | HYNNSVVRRE |
600:
WHNLISEEKT | GKRRSAAYVR | NILDNAVKVI | SNLEARNLGP | RLTPLLQEED |
650:
SHQRLLMGLM | VSELKDHFLR | HLQGVEKKKI | EQMVLDYISK | LLDLICHIVE |
700:
TNWRKHNLHS | WVLHFNSRGS | AAEFAVFHIM | TRILEATNSL | FLPLPPGFHT |
750:
LHTILGVQCL | PLHNLLHCID | SGVLLLTETA | VIRLMKDLDN | TEKNEKLKFS |
800:
IIVRLPPLIG | QKICRLWDHP | MSSNIISRNH | VTRLLQNYKK | QPRNSMINKS |
850:
SFSVEFLPLN | YFIEILTDIE | SSNQALYPFE | GHDNVDAEFV | EEAALKHTAM |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Mouse
Polyclonal Antibody for Human GSAP
Polyclonal Antibody for Human GSAP
Monoclonal Antibody for Human GSAP
Monoclonal Antibody for Human GSAP
R&D Technical Data
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Precision
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Recovery
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Linearity
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Cited for : FUNCTION;SUBCELLULAR LOCATION;IDENTIFICATION BY MASS SPECTROMETRY;PROTEOLYTIC PROCESSING;IMATINIB-BINDING;TISSUE SPECIFICITY;INTERACTION WITH APP AND THE GAMMA-SECRETASE COMPLEX