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Index > Protein center > GSAP(Gene name) > Human
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  • GSAP (Gene name),
  • Gamma-secretase-activating protein (Protein name ),  GSAP_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    GSAP(PION);
    Protein name:
    Gamma-secretase-activating protein(GSAP);
    Alternative:
    Protein pigeon homolog;
    Organism:
    GSAP (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with APP; specifically interacts with the CTF-alpha product of APP. Interacts with the gamma-secretase complex.
    Function:
    Regulator of gamma-secretase activity, which specifically activates the production of beta-amyloid protein (beta-amyloid protein 40 and beta-amyloid protein 42), without affecting the cleavage of other gamma-secretase targets such has Notch. The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Specifically promotes the gamma-cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate beta-amyloid, while it reduces the epsilon-cleavage of APP CTF-alpha, leading to a low production of AICD.
    Subcellular Location:
    Golgi apparatus trans-Golgi network
    Protein Attributes:
    Sequence length:
    854
    Sequence:
    50:
    MALRLVADFD | LGKDVLPWLR | AQRAVSEASG | AGSGGADVLE | NDYESLHVLN | 
    100:
    VERNGNIIYT | YKDDKGNVVF | GLYDCQTRQN | ELLYTFEKDL | QVFSCSVNSE | 
    150:
    RTLLAASLVQ | STKEGKRNEL | QPGSKCLTLL | VEIHPVNNVK | VLKAVDSYIW | 
    200:
    VQFLYPHIES | HPLPENHLLL | ISEEKYIEQF | RIHVAQEDGN | RVVIKNSGHL | 
    250:
    PRDRIAEDFV | WAQWDMSEQR | LYYIDLKKSR | SILKCIQFYA | DESYNLMFEV | 
    300:
    PLDISLSNSG | FKLVNFGCDY | HQYRDKFSKH | LTLCVFTNHT | GSLCVCYSPK | 
    350:
    CASWGQITYS | VFYIHKGHSK | TFTTSLENVG | SHMTKGITFL | NLDYYVAVYL | 
    400:
    PGHFFHLLNV | QHPDLICHNL | FLTGNNEMID | MLPHCPLQSL | SGSLVLDCCS | 
    450:
    GKLYRALLSQ | SSLLQLLQNT | CLDCEKMAAL | HCALYCGQGA | QFLEAQIIQW | 
    500:
    ISENVSACHS | FDLIQEFIIA | SSYWSVYSET | SNMDKLLPHS | SVLTWNTEIP | 
    550:
    GITLVTEDIA | LPLMKVLSFK | GYWEKLNSNL | EYVKYAKPHF | HYNNSVVRRE | 
    600:
    WHNLISEEKT | GKRRSAAYVR | NILDNAVKVI | SNLEARNLGP | RLTPLLQEED | 
    650:
    SHQRLLMGLM | VSELKDHFLR | HLQGVEKKKI | EQMVLDYISK | LLDLICHIVE | 
    700:
    TNWRKHNLHS | WVLHFNSRGS | AAEFAVFHIM | TRILEATNSL | FLPLPPGFHT | 
    750:
    LHTILGVQCL | PLHNLLHCID | SGVLLLTETA | VIRLMKDLDN | TEKNEKLKFS | 
    800:
    IIVRLPPLIG | QKICRLWDHP | MSSNIISRNH | VTRLLQNYKK | QPRNSMINKS | 
    850:
    SFSVEFLPLN | YFIEILTDIE | SSNQALYPFE | GHDNVDAEFV | EEAALKHTAM | 
    854:
    LLGL
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    String:
    KEGG:
    MIM:
    Uniprot:
     
    FOR
    ELISA Kit for Human GSAP
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    E2079h
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    Packing:
    96T
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    ELISA Kit for Human GSAP
    Cat.:
    E2079m
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    MSDS:
    Please sign in first.
    Packing:
    96T
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    CLIA Kit for Human GSAP
    Cat.:
    U2079h
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human GSAP
    Cat.:
    U2079m
    Price:
    Please sign in first.
    MSDS:
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    Packing:
    96T
    Polyclonal Antibody for Human GSAP
    Cat.:
    P2079Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human GSAP
    Cat.:
    P2079Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human GSAP
    Monoclonal Antibody for Human GSAP
    Protein for Human GSAP
    Protein for Human GSAP

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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "The DNA sequence of human chromosome 7."
      Hillier L.W. , Fulton R.S. , Fulton L.A. , Graves T.A. , Pepin K.H. , Wagner-McPherson C. , Layman D. , Maas J. , Jaeger S. , Walker R. , Wylie K. , Sekhon M. , Becker M.C. , O'Laughlin M.D. , Schaller M.E. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , more...
      Nature424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    2. 2.
      "Human chromosome 7: DNA sequence and biology."
      Scherer S.W. , Cheung J. , MacDonald J.R. , Osborne L.R. , Nakabayashi K. , Herbrick J.-A. , Carson A.R. , Parker-Katiraee L. , Skaug J. , Khaja R. , Zhang J. , Hudek A.K. , Li M. , Haddad M. , Duggan G.E. , Fernandez B.A. , Kanematsu E. , Gentles S. , more...
      Science300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT ARG-47
    3. 3.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4)
      tissue: Brain.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 36-854 (ISOFORM 3)
      tissue: Lymph node.
    6. 6.
      The European IMAGE consortium
      Submitted (2000-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 587-854
    7. 7.
      "Gamma-secretase activating protein is a therapeutic target for Alzheimer's disease."
      He G. , Luo W. , Li P. , Remmers C. , Netzer W.J. , Hendrick J. , Bettayeb K. , Flajolet M. , Gorelick F. , Wennogle L.P. , Greengard P.
      Nature467:95-98(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;IDENTIFICATION BY MASS SPECTROMETRY;PROTEOLYTIC PROCESSING;IMATINIB-BINDING;TISSUE SPECIFICITY;INTERACTION WITH APP AND THE GAMMA-SECRETASE COMPLEX
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