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Index > Protein center > GSR(Gene name) > Human
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  • GSR (Gene name),
  • Glutathione reductase, mitochondrial (Protein name ),  GSHR_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    GSR(GLUR;GRD1);
    Protein name:
    Glutathione reductase, mitochondrial(GR;GRase);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homodimer; disulfide-linked.
    Function:
    Maintains high levels of reduced glutathione in the cytosol.
    Subcellular Location:
    Isoform Cytoplasmic Cytoplasm
    Protein Attributes:
    Sequence length:
    522
    Sequence:
    50:
    MALLPRALSA | GAGPSWRRAA | RAFRGFLLLL | PEPAALTRAL | SRAMACRQEP | 
    100:
    QPQGPPPAAG | AVASYDYLVI | GGGSGGLASA | RRAAELGARA | AVVESHKLGG | 
    150:
    TCVNVGCVPK | KVMWNTAVHS | EFMHDHADYG | FPSCEGKFNW | RVIKEKRDAY | 
    200:
    VSRLNAIYQN | NLTKSHIEII | RGHAAFTSDP | KPTIEVSGKK | YTAPHILIAT | 
    250:
    GGMPSTPHES | QIPGASLGIT | SDGFFQLEEL | PGRSVIVGAG | YIAVEMAGIL | 
    300:
    SALGSKTSLM | IRHDKVLRSF | DSMISTNCTE | ELENAGVEVL | KFSQVKEVKK | 
    350:
    TLSGLEVSMV | TAVPGRLPVM | TMIPDVDCLL | WAIGRVPNTK | DLSLNKLGIQ | 
    400:
    TDDKGHIIVD | EFQNTNVKGI | YAVGDVCGKA | LLTPVAIAAG | RKLAHRLFEY | 
    450:
    KEDSKLDYNN | IPTVVFSHPP | IGTVGLTEDE | AIHKYGIENV | KTYSTSFTPM | 
    500:
    YHAVTKRKTK | CVMKMVCANK | EEKVVGIHMQ | GLGCDEMLQG | FAVAVKMGAT | 
    522:
    KADFDNTVAI | HPTSSEELVT | LR
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    Pfam:
    String:
    KEGG:
    MIM:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Human GR
    Cat.:
    E2081h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human GR
    Cat.:
    E2081r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human GR
    Cat.:
    E2081m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human GR
    Cat.:
    U2081m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human GR
    Cat.:
    U2081r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human GR
    Cat.:
    U2081h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human GR
    Cat.:
    P2081Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human GR
    Cat.:
    P2081Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human GR
    Cat.:
    P2081Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human GR
    Monoclonal Antibody for Human GR
    Monoclonal Antibody for Human GR
    Protein for Human GR
    Protein for Human GR
    Protein for Human GR

    R&D Technical Data
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    s

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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤8.1%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤10.5%

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    Recovery was determined by spiking various levels of GSHR into serum and plasma .

    Sample Type

    Average(%)

    Recovery Range(%)

    Serum

    95

    92-104

    Plasma

    96

    93-107

     

     

     

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of GSHR and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    92-97%

    90-101%

    92-100%

    91-99%

    EDTA plasma(n=5)

    91-103%

    94-98%

    90-102%

    92-99%

    heparin plasma(n=5)

    93-100%

     

    92-99%

    91-101%

    90-103%

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    References
    1. 1.
      "Cloning and sequencing of mammalian glutathione reductase cDNA."
      Tutic M. , Lu X.A. , Schirmer R.H. , Werner D.
      Eur. J. Biochem.188:523-528(1990) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM CYTOPLASMIC)
      tissue: Placenta.
    2. 2.
      "Structural organization of the human glutathione reductase (GSR) gene: determination of correct cDNA sequence and identification of a mitochondrial leader sequence."
      Kelner M.J. , Montoya M.A.
      Biochem. Biophys. Res. Commun.269:366-368(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM MITOCHONDRIAL);ALTERNATIVE INITIATION
    3. 3.
      NIEHS SNPs program
      Submitted (2003-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANTS CYS-153; SER-232; VAL-261 AND ASP-297
    4. 4.
      "Expression of glutathione reductase splice variants in human tissues."
      Satoh N. , Watanabe N. , Kanda A. , Sugaya-Fukazawa M. , Hisatomi H.
      Biochem. Genet.48:816-821(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 2; 3 AND 4);ALTERNATIVE SPLICING;TISSUE SPECIFICITY
    5. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM MITOCHONDRIAL)
      tissue: Lung.
    7. 8.
      "Glutathione reductase from human erythrocytes. The sequences of the NADPH domain and of the interface domain."
      Krauth-Siegel R.L. , Blatterspiel R. , Saleh M. , Schiltz E. , Schirmer R.H. , Untucht-Grau R.
      Eur. J. Biochem.121:259-267(1982) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 45-522
    8. 9.
      "Glutathione reductase from human erythrocytes. Isolation of the enzyme and sequence analysis of the redox-active peptide."
      Krohne-Ehrich G. , Schirmer R.H. , Untucht-Grau R.
      Eur. J. Biochem.80:65-71(1977) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 98-110
      tissue: Erythrocyte.
    9. 10.
      "Immunoaffinity profiling of tyrosine phosphorylation in cancer cells."
      Rush J. , Moritz A. , Lee K.A. , Guo A. , Goss V.L. , Spek E.J. , Zhang H. , Zha X.-M. , Polakiewicz R.D. , Comb M.J.
      Nat. Biotechnol.23:94-101(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    10. 11.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 12.
      "Three-dimensional structure of glutathione reductase at 2-A resolution."
      Thieme R. , Pai E.F. , Schirmer R.H. , Schulz G.E.
      J. Mol. Biol.152:763-782(1981) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2 ANGSTROMS) OF 45-522
    12. 13.
      "Refined structure of glutathione reductase at 1.54-A resolution."
      Karplus P.A. , Schulz G.E.
      J. Mol. Biol.195:701-729(1987) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.57 ANGSTROMS) OF 45-522
    13. 14.
      "Kinetics and crystallographic analysis of human glutathione reductase in complex with a xanthene inhibitor."
      Savvides S.N. , Karplus P.A.
      J. Biol. Chem.271:8101-8107(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) OF 62-522;DISULFIDE BONDS
    14. 15.
      "Glutathione reductase turned into trypanothione reductase: structural analysis of an engineered change in substrate specificity."
      Stoll V.S. , Simpson S.J. , Krauth-Siegel R.L. , Walsh C.T. , Pai E.F.
      Biochemistry36:6437-6447(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.4 ANGSTROMS) OF 62-522
    15. 16.
      "Enzyme inactivation through sulfhydryl oxidation by physiologic NO-carriers."
      Becker K. , Savvides S.N. , Keese M. , Schirmer R.H. , Karplus P.A.
      Nat. Struct. Biol.5:267-271(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.7 ANGSTROMS) OF 62-522
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