Gsk3a ELISA Kit for Mouse(Mus musculus) | EIAab.comGsk3a ELISA Kit for Mouse(Mus musculus)

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Gsk3a (Gene name),

Glycogen synthase kinase-3 alpha (Protein name ), GSK3A_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

Gsk3a;

Protein name:

Glycogen synthase kinase-3 alpha(GSK-3 alpha);

Alternative:

2.7.11.1;Serine/threonine-protein kinase GSK3A);

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Monomer. Interacts with AXIN1 and CTNNB1/beta-catenin (By similarity). Interacts with ARRB2.

Function:

Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transctiption factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

490

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

490:

GPASPLTTSY | NPSSQALTEA | QTGQDWQPSD | ATTATLASSS |

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q2NL51

String:

Q2NL51

UniGene:

Mm.491101

KEGG:

mmu:606496

STRING:

10090.ENSMUSP00000071654

Pfam:

PF00069

Uniprot:

Q2NL51

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ELISA Kit for Mouse GSK-3 alpha

Cat.:

E0767m

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96T

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ELISA Kit for Mouse GSK-3 alpha

Cat.:

E0767r

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96T

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ELISA Kit for Mouse GSK-3 alpha

Cat.:

E0767h

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96T

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CLIA Kit for Mouse GSK-3 alpha

Cat.:

U0767h

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MSDS:

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Packing:

96T

CLIA Kit for Mouse GSK-3 alpha

Cat.:

U0767m

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MSDS:

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Packing:

96T

CLIA Kit for Mouse GSK-3 alpha

Cat.:

U0767r

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Packing:

96T

Polyclonal Antibody for Mouse GSK-3 alpha

Cat.:

P0767Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse GSK-3 alpha

Cat.:

P0767Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Mouse GSK-3 alpha

Cat.:

P0767Rb-m

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Packing:

40ug/0.2ml

Monoclonal Antibody for Mouse GSK-3 alpha

Protein for Mouse GSK-3 alpha

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M. , Goodstadt L. , Hillier L.W. , Zody M.C. , Goldstein S. , She X. , Bult C.J. , Agarwala R. , Cherry J.L. , DiCuccio M. , Hlavina W. , Kapustin Y. , Meric P. , Maglott D. , Birtle Z. , Marques A.C. , Graves T. , Zhou S. , more...
PLoS Biol.7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain: C57BL/6J.
2.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 227-490
tissue: Eye.
3.

"An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior."
Beaulieu J.-M. , Sotnikova T.D. , Marion S. , Lefkowitz R.J. , Gainetdinov R.R. , Caron M.G.
Cell122:261-273(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ARRB2
4.

"Role that phosphorylation of GSK3 plays in insulin and Wnt signalling defined by knockin analysis."
McManus E.J. , Sakamoto K. , Armit L.J. , Ronaldson L. , Shpiro N. , Marquez R. , Alessi D.R.
EMBO J.24:1571-1583(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF SER-21;PHOSPHORYLATION AT SER-21
5.

"Glycogen synthase kinase-3 regulates mitochondrial outer membrane permeabilization and apoptosis by destabilization of MCL-1."
Maurer U. , Charvet C. , Wagman A.S. , Dejardin E. , Green D.R.
Mol. Cell21:749-760(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN MCL1 PHOSPHORYLATION
6.

"GSK3 alpha and GSK3 beta are necessary for axon formation."
Garrido J.J. , Simon D. , Varea O. , Wandosell F.
FEBS Lett.581:1579-1586(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN AXON FORMATION;TISSUE SPECIFICITY
7.

"Glycogen synthase kinase 3alpha-specific regulation of murine hepatic glycogen metabolism."
MacAulay K. , Doble B.W. , Patel S. , Hansotia T. , Sinclair E.M. , Drucker D.J. , Nagy A. , Woodgett J.R.
Cell Metab.6:329-337(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN HEPATIC GLYCOGEN METABOLISM;DISRUPTION PHENOTYPE

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