Gsk3a ELISA Kit for Rat(Rattus norvegicus) | EIAab.comGsk3a ELISA Kit for Rat(Rattus norvegicus)

Search Protein-oriented Product center.

For antibodies, ELISA/CLIA, proteins... Product center

Tips

Index > Protein center > Gsk3a(Gene name) > Rat

Gsk3a (Gene name),

Glycogen synthase kinase-3 alpha (Protein name ), GSK3A_RAT from NCBI database.

top

General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Feedback

Gene name:

Gsk3a;

Protein name:

Glycogen synthase kinase-3 alpha(GSK-3 alpha);

Alternative:

2.7.11.1;Serine/threonine-protein kinase GSK3A);Factor A(FA);

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

Monomer. Interacts with ARRB2, AXIN1 and CTNNB1/beta-catenin.

Function:

Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transctiption factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establishment of neuronal polarity and axon outgrowth.

Subcellular Location:

N/A

Protein Attributes:

Sequence length:

483

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

483:

PATLTSSSQA | LTETQTGQDW | QAPDATPTLT | NSS

3D Structure:

N/A

Predicted Eptitope:

Please Sign in.

Vaild Sequence:

Please Sign in.

Related Databases

SMR:

P18265

String:

P18265

STRING:

10116.ENSRNOP00000027677

Pfam:

PF00069

KEGG:

rno:50686

UniGene:

Rn.36807

Uniprot:

P18265

FOR

ELISA Kit for Rat GSK-3 alpha

Cat.:

E0767m

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Rat GSK-3 alpha

Cat.:

E0767r

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

ELISA Kit for Rat GSK-3 alpha

Cat.:

E0767h

Price:

Please sign in first.

Manual:

Looking for manual.

MSDS:

Please sign in first.

Packing:

96T

Range:

Please sign in first.

CLIA Kit for Rat GSK-3 alpha

Cat.:

U0767h

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Rat GSK-3 alpha

Cat.:

U0767m

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

CLIA Kit for Rat GSK-3 alpha

Cat.:

U0767r

Price:

Please sign in first.

MSDS:

Please sign in first.

Packing:

96T

Polyclonal Antibody for Rat GSK-3 alpha

Cat.:

P0767Rb-r

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Rat GSK-3 alpha

Cat.:

P0767Rb-h

Price:

Please sign in first.

Packing:

40ug/0.2ml

Polyclonal Antibody for Rat GSK-3 alpha

Cat.:

P0767Rb-m

Price:

Please sign in first.

Packing:

40ug/0.2ml

Monoclonal Antibody for Rat GSK-3 alpha

Protein for Rat GSK-3 alpha

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"Molecular cloning and expression of glycogen synthase kinase-3/factor A."
Woodgett J.R.
EMBO J.9:2431-2438(1990) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
strain: Sprague-Dawley.
tissue: Brain.
2.

"Modulation of the glycogen synthase kinase-3 family by tyrosine phosphorylation."
Hughes K. , Nikolakaki E. , Plyte S.E. , Totty N.F. , Woodgett J.R.
EMBO J.12:803-808(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION AT TYR-279
3.

"Inhibition of GSK3 promotes replication and survival of pancreatic beta cells."
Mussmann R. , Geese M. , Harder F. , Kegel S. , Andag U. , Lomow A. , Burk U. , Onichtchouk D. , Dohrmann C. , Austen M.
J. Biol. Chem.282:12030-12037(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN REGULATION OF PANCREATIC BETA-CELLS

Product Feedback Wall

* Email:
*Comments: