GSTA1 ELISA Kit for Human(Homo sapiens) | EIAab.comGSTA1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > GSTA1(Gene name) > Human

GSTA1 (Gene name),

Glutathione S-transferase A1 (Protein name ), GSTA1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

GSTA1;

Protein name:

Glutathione S-transferase A1;

Alternative:

GST class-alpha member 1;GST HA subunit 1;GSTA1-1;GST-epsilon;GTH1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Homodimer or heterodimer of GSTA1 and GSTA2.

Function:

Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles.

Subcellular Location:

Cytoplasm

Protein Attributes:

Sequence length:

222

Sequence:

50:

100:

150:

200:

222:

GSPRKPPMDE | KSLEEARKIF | RF

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

UniGene:

Hs.446309

String:

P08263

KEGG:

hsa:2938

STRING:

9606.ENSP00000335620

SMR:

P08263

MIM:

138359

Pfam:

PF00043

Uniprot:

P08263

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ELISA Kit for Human Glutathione S-transferase A1

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E8885h

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96T

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ELISA Kit for Human Glutathione S-transferase A1

Cat.:

E8885m

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96T

ELISA Kit for Human Glutathione S-transferase A1

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E8885r

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96T

ELISA Kit for Human Glutathione S-transferase A1

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E8885b

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96T

CLIA Kit for Human Glutathione S-transferase A1

Cat.:

U8885r

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96T

CLIA Kit for Human Glutathione S-transferase A1

Cat.:

U8885h

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96T

CLIA Kit for Human Glutathione S-transferase A1

Cat.:

U8885b

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96T

CLIA Kit for Human Glutathione S-transferase A1

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U8885m

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96T

Polyclonal Antibody for Human Glutathione S-transferase A1

Cat.:

P8885Rb-h

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40ug/0.2ml

Polyclonal Antibody for Human Glutathione S-transferase A1

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P8885Rb-r

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Polyclonal Antibody for Human Glutathione S-transferase A1

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P8885Rb-m

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Monoclonal Antibody for Human Glutathione S-transferase A1

Protein for Human Glutathione S-transferase A1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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References

1.

"Human liver glutathione S-transferases: complete primary sequence of an Ha subunit cDNA."
Tu C.-P.D. , Qian B.
Biochem. Biophys. Res. Commun.141:229-237(1986) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
2.

"The basic glutathione S-transferases from human livers are products of separate genes."
Rhoads D.M. , Zarlengo R.P. , Tu C.-P.D.
Biochem. Biophys. Res. Commun.145:474-481(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"Nucleotide sequence of the human liver glutathione S-transferase subunit 1 cDNA."
Tu C.-P.D. , Qian B.
Biochem. Soc. Trans.15:734-736(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Liver.
4.

"Isolation of a cDNA clone and localization of human glutathione S-transferase 2 genes to chromosome band 6p12."
Board P.G. , Webb G.C.
Proc. Natl. Acad. Sci. U.S.A.84:2377-2381(1987) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
5.

"Isolation and characterization of a human glutathione S-transferase Ha1 subunit gene."
Rozen F. , Nguyen T. , Pickett C.B.
Arch. Biochem. Biophys.292:589-593(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
6.

"Heterologous expression of recombinant human glutathione transferase A1-1 from a hepatoma cell line."
Stenberg G. , Bjornestedt R. , Mannervik B.
Protein Expr. Purif.3:80-84(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
7.

Chen P. , Zhang C. , Xie D. , Wu Y. , Han L. , Chen L.
Submitted (2004-01) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Liver.
8.

"The DNA sequence and analysis of human chromosome 6."
Mungall A.J. , Palmer S.A. , Sims S.K. , Edwards C.A. , Ashurst J.L. , Wilming L. , Jones M.C. , Horton R. , Hunt S.E. , Scott C.E. , Gilbert J.G.R. , Clamp M.E. , Bethel G. , Milne S. , Ainscough R. , Almeida J.P. , Ambrose K.D. , Andrews T.D. , more...
Nature425:805-811(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
9.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-07) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
10.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.
11.

"Human glutathione S-transferases. The Ha multigene family encodes products of different but overlapping substrate specificities."
Chow N.W. , Whang-Peng J. , Kao-Shan C.S. , Tam M.F. , Lai H.-C.J. , Tu C.-P.D.
J. Biol. Chem.263:12797-12800(1988) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE OF 1-9
12.

"Characterization of two novel subunits of the alpha-class glutathione S-transferases of human liver."
Ahmad H. , Singhal S.S. , Saxena M. , Awasthi Y.C.
Biochim. Biophys. Acta1161:333-336(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 2-170; 188-195 AND 209-222
13.

"Evidence that glutathione S-transferases B1B1 and B2B2 are the products of separate genes and that their expression in human liver is subject to inter-individual variation. Molecular relationships between the B1 and B2 subunits and other alpha class glutathione S-transferases."
Hayes J.D. , Kerr L.A. , Cronshaw A.D.
Biochem. J.264:437-445(1989) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 16-36; 63-155 AND 208-212
14.

"The contribution of the C-terminal sequence to the catalytic activity of GST2, a human alpha-class glutathione transferase."
Board P.G. , Mannervik B.
Biochem. J.275:171-174(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 200-222
15.

"Structure determination and refinement of human alpha class glutathione transferase A1-1, and a comparison with the Mu and Pi class enzymes."
Sinning I. , Kleywegt G.J. , Cowan S.W. , Reinemer P. , Dirr H.W. , Huber R. , Gilliland G.L. , Armstrong R.N. , Ji X. , Board P.G. , Olin B. , Mannervik B. , Jones T.A.
J. Mol. Biol.232:192-212(1993) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) IN COMPLEX WITH S-BENZYL-GLUTATHIONE;SUBUNIT
16.

"Structural analysis of human alpha-class glutathione transferase A1-1 in the apo-form and in complexes with ethacrynic acid and its glutathione conjugate."
Cameron A.D. , Sinning I. , L'Hermite G. , Olin B. , Board P.G. , Mannervik B. , Jones T.A.
Structure3:717-727(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.5 ANGSTROMS) IN COMPLEXES WITH ETHACRYNIC ACID AND GLUTATHIONE;SUBUNIT
17.

"1.3-A resolution structure of human glutathione S-transferase with S-hexyl glutathione bound reveals possible extended ligandin binding site."
Le Trong I. , Stenkamp R.E. , Ibarra C. , Atkins W.M. , Adman E.T.
Proteins48:618-627(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.3 ANGSTROMS) IN COMPLEXES WITH S-HEXYL GLUTATHIONE;SUBUNIT
18.

"Incorporation of a single His residue by rational design enables thiol-ester hydrolysis by human glutathione transferase A1-1."
Hederos S. , Broo K.S. , Jakobsson E. , Kleywegt G.J. , Mannervik B. , Baltzer L.
Proc. Natl. Acad. Sci. U.S.A.101:13163-13167(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.07 ANGSTROMS) IN COMPLEX WITH S-BENZYLGLUTATHIONE;MUTAGENESIS OF ALA-216
19.

"Tertiary interactions stabilise the C-terminal region of human glutathione transferase A1-1: a crystallographic and calorimetric study."
Kuhnert D.C. , Sayed Y. , Mosebi S. , Sayed M. , Sewell T. , Dirr H.W.
J. Mol. Biol.349:825-838(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.95 ANGSTROMS) OF MUTANT ALA-219 IN COMPLEX WITH S-HEXYLGLUTATHIONE
20.

"New crystal structures of human glutathione transferase A1-1 shed light on glutathione binding and the conformation of the C-terminal helix."
Grahn E. , Novotny M. , Jakobsson E. , Gustafsson A. , Grehn L. , Olin B. , Madsen D. , Wahlberg M. , Mannervik B. , Kleywegt G.J.
Acta Crystallogr. D62:197-207(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) IN COMPLEX WITH GLUTATHIONE;SUBUNIT
21.

"Structural analysis of a glutathione transferase A1-1 mutant tailored for high catalytic efficiency with toxic alkenals."
Balogh L.M. , Le Trong I. , Kripps K.A. , Tars K. , Stenkamp R.E. , Mannervik B. , Atkins W.M.
Biochemistry48:7698-7704(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.98 ANGSTROMS) OF 1-210 IN COMPLEX WITH GLUTATHIONE
22.

"The role of a topologically conserved isoleucine in glutathione transferase structure, stability and function."
Achilonu I. , Gildenhuys S. , Fisher L. , Burke J. , Fanucchi S. , Sewell B.T. , Fernandes M. , Dirr H.W.
Acta Crystallogr. F66:776-780(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.75 ANGSTROMS) OF MUTANTS ALA-71 AND VAL-71 IN COMPLEX WITH S-HEXYLGLUTATHIONE;FUNCTION;CATALYTIC ACTIVITY;MUTAGENESIS OF ILE-71

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