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Index > Protein center > GUCY2C(Gene name) > Human
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  • GUCY2C (Gene name),
  • Heat-stable enterotoxin receptor (Protein name ),  GUC2C_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    GUCY2C(GUC2C;STAR);
    Protein name:
    Heat-stable enterotoxin receptor(STA receptor;hSTAR);
    Alternative:
    Intestinal guanylate cyclase;Guanylyl cyclase C(GC-C);
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homotrimer. Interacts via its C-terminal region with PDZK2.
    Function:
    Receptor for the E.coli heat-stable enterotoxin (E.coli enterotoxin markedly stimulates the accumulation of cGMP in mammalian cells expressing GC-C). Also activated by the endogenous peptide guanylin.
    Subcellular Location:
    Membrane Single-pass type I membrane protein
    Protein Attributes:
    Sequence length:
    1073
    Sequence:
    50:
    MKTLLLDLAL | WSLLFQPGWL | SFSSQVSQNC | HNGSYEISVL | MMGNSAFAEP | 
    100:
    LKNLEDAVNE | GLEIVRGRLQ | NAGLNVTVNA | TFMYSDGLIH | NSGDCRSSTC | 
    150:
    EGLDLLRKIS | NAQRMGCVLI | GPSCTYSTFQ | MYLDTELSYP | MISAGSFGLS | 
    200:
    CDYKETLTRL | MSPARKLMYF | LVNFWKTNDL | PFKTYSWSTS | YVYKNGTETE | 
    250:
    DCFWYLNALE | ASVSYFSHEL | GFKVVLRQDK | EFQDILMDHN | RKSNVIIMCG | 
    300:
    GPEFLYKLKG | DRAVAEDIVI | ILVDLFNDQY | FEDNVTAPDY | MKNVLVLTLS | 
    350:
    PGNSLLNSSF | SRNLSPTKRD | FALAYLNGIL | LFGHMLKIFL | ENGENITTPK | 
    400:
    FAHAFRNLTF | EGYDGPVTLD | DWGDVDSTMV | LLYTSVDTKK | YKVLLTYDTH | 
    450:
    VNKTYPVDMS | PTFTWKNSKL | PNDITGRGPQ | ILMIAVFTLT | GAVVLLLLVA | 
    500:
    LLMLRKYRKD | YELRQKKWSH | IPPENIFPLE | TNETNHVSLK | IDDDKRRDTI | 
    550:
    QRLRQCKYDK | KRVILKDLKH | NDGNFTEKQK | IELNKLLQID | YYNLTKFYGT | 
    600:
    VKLDTMIFGV | IEYCERGSLR | EVLNDTISYP | DGTFMDWEFK | ISVLYDIAKG | 
    650:
    MSYLHSSKTE | VHGRLKSTNC | VVDSRMVVKI | TDFGCNSILP | PKKDLWTAPE | 
    700:
    HLRQANISQK | GDVYSYGIIA | QEIILRKETF | YTLSCRDRNE | KIFRVENSNG | 
    750:
    MKPFRPDLFL | ETAEEKELEV | YLLVKNCWEE | DPEKRPDFKK | IETTLAKIFG | 
    800:
    LFHDQKNESY | MDTLIRRLQL | YSRNLEHLVE | ERTQLYKAER | DRADRLNFML | 
    850:
    LPRLVVKSLK | EKGFVEPELY | EEVTIYFSDI | VGFTTICKYS | TPMEVVDMLN | 
    900:
    DIYKSFDHIV | DHHDVYKVET | IGDAYMVASG | LPKRNGNRHA | IDIAKMALEI | 
    950:
    LSFMGTFELE | HLPGLPIWIR | IGVHSGPCAA | GVVGIKMPRY | CLFGDTVNTA | 
    1000:
    SRMESTGLPL | RIHVSGSTIA | ILKRTECQFL | YEVRGETYLK | GRGNETTYWL | 
    1050:
    TGMKDQKFNL | PTPPTVENQQ | RLQAEFSDMI | ANSLQKRQAA | GIRSQKPRRV | 
    1073:
    ASYKKGTLEY | LQLNTTDKES | TYF
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    Pfam:
    UniGene:
    String:
    MIM:
    SMR:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human STA receptor
    Cat.:
    E14905h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human STA receptor
    MSDS:
    Please sign in first.
    ELISA Kit for Human STA receptor
    MSDS:
    Please sign in first.
    ELISA Kit for Human STA receptor
    Cat.:
    E14905m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human STA receptor
    Cat.:
    U14905m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human STA receptor
    MSDS:
    Please sign in first.
    CLIA Kit for Human STA receptor
    MSDS:
    Please sign in first.
    CLIA Kit for Human STA receptor
    Cat.:
    U14905h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    Polyclonal Antibody for Human STA receptor
    Polyclonal Antibody for Human STA receptor
    Polyclonal Antibody for Human STA receptor
    Polyclonal Antibody for Human STA receptor
    Monoclonal Antibody for Human STA receptor
    Monoclonal Antibody for Human STA receptor
    Monoclonal Antibody for Human STA receptor
    Monoclonal Antibody for Human STA receptor
    Protein for Human STA receptor
    Protein for Human STA receptor
    Protein for Human STA receptor
    Protein for Human STA receptor

    R&D Technical Data

    s

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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    s
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision

    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤3.9%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤7.7%

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤3.9%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤7.7%

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Recovery

    Recovery was determined by spiking various levels of ACE into serum and plasma .

    Sample Type

    Average(%)

    Recovery Range(%)

    Serum

    99

    91-103

    Plasma

    98

    93-106

     

     

     

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

    Recovery was determined by spiking various levels of ACE into serum and plasma .

    Sample Type

    Average(%)

    Recovery Range(%)

    Serum

    99

    91-103

    Plasma

    98

    93-106

     

     

     

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Linearity

     

    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    92-105%

    90-101%

    95-105%

    92-109%

    EDTA plasma(n=5)

    89-95%

    93105%

    89-94%

    90-106%

    heparin plasma(n=5)

    93-104%

     

    94-110%

    101-111%

    91-110%

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

     

    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    92-105%

    90-101%

    95-105%

    92-109%

    EDTA plasma(n=5)

    89-95%

    93105%

    89-94%

    90-106%

    heparin plasma(n=5)

    93-104%

     

    94-110%

    101-111%

    91-110%

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Isolation and expression of a guanylate cyclase-coupled heat stable enterotoxin receptor cDNA from a human colonic cell line."
      Singh S. , Singh G. , Heim J.-M. , Gerzer R.
      Biochem. Biophys. Res. Commun.179:1455-1463(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT LEU-281
    2. 2.
      "Primary structure and functional expression of the human receptor for Escherichia coli heat-stable enterotoxin."
      de Sauvage F.J. , Camerato T.R. , Goeddel D.V.
      J. Biol. Chem.266:17912-17918(1991) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];VARIANT LEU-281
    3. 3.
      "The finished DNA sequence of human chromosome 12."
      Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
      Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    4. 4.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA];VARIANT LEU-281
    5. 5.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT LEU-281
    6. 6.
      "Cell line-specific transcriptional activation of the promoter of the human guanylyl cyclase C/heat-stable enterotoxin receptor gene."
      Mann E.A. , Jump M.L. , Giannella R.A.
      Biochim. Biophys. Acta1305:7-10(1996) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-72
      tissue: Placenta.
    7. 7.
      "Comparison of receptors for Escherichia coli heat-stable enterotoxin: novel receptor present in IEC-6 cells."
      Mann E.A. , Cohen M.B. , Giannella R.A.
      Am. J. Physiol.264:G172-G178(1993) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 24-1073;VARIANT LEU-281
      tissue: Colon carcinoma.
    8. 8.
      "Biochemical characterization of the intracellular domain of the human guanylyl cyclase C receptor provides evidence for a catalytically active homotrimer."
      Vijayachandra K. , Guruprasad M. , Bhandari R. , Manjunath U.H. , Somesh B.P. , Srinivasan N. , Suguna K. , Visweswariah S.S.
      Biochemistry39:16075-16083(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBUNIT
    9. 9.
      "A novel PDZ protein regulates the activity of guanylyl cyclase C, the heat-stable enterotoxin receptor."
      Scott R.O. , Thelin W.R. , Milgram S.L.
      J. Biol. Chem.277:22934-22941(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PDZK2
    10. 10.
      "Site-specific N-linked glycosylation of receptor guanylyl cyclase C regulates ligand binding, ligand-mediated activation and interaction with vesicular integral membrane protein 36, VIP36."
      Arshad N. , Ballal S. , Visweswariah S.S.
      J. Biol. Chem.288:3907-3917(2013) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT ASN-32; ASN-75; ASN-79; ASN-195; ASN-284; ASN-307; ASN-345 AND ASN-402;ABSENCE OF GLYCOSYLATION AT ASN-357;INTERACTION WITH VIP36;SUBCELLULAR LOCATION
    11. 11.
      "Meconium ileus caused by mutations in GUCY2C, encoding the CFTR-activating guanylate cyclase 2C."
      Romi H. , Cohen I. , Landau D. , Alkrinawi S. , Yerushalmi B. , Hershkovitz R. , Newman-Heiman N. , Cutting G.R. , Ofir R. , Sivan S. , Birk O.S.
      Am. J. Hum. Genet.90:893-899(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MECIL GLY-387;CHARACTERIZATION OF VARIANT MECIL GLY-387
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT DIAR6 ILE-840;CHARACTERIZATION OF VARIANT DIAR6 ILE-840
    13. 13.
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