Gene name:
MASTL (GW;GWL) ;
Protein name:
Serine/threonine-protein kinase greatwall (GW;GWL) ;
Alternative:
Microtubule-associated serine/threonine-protein kinase-like (MAST-L) ;
Organism:
Chicken (Gallus gallus).
General Annotation
Function:
Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited.
Subcellular Location:
Cytoplasm
cytoskeleton
centrosome
Nucleus
During interphase is mainly nuclear, upon nuclear envelope breakdown localizes at the cytoplasm and during mitosis at the centrosomes.
Protein Attributes:
50:
MSTVEPLSDE | GVAAGPRRIE | VPRPPSIEEF | TIVKPISRGA | FGKVYLGRKA |
100:
GRLYAVKVMK | KADMINKNMV | HQVQAERDAL | ALSKSPFIVH | LYYSLQSANN |
150:
VYLVMEYLIG | GDVKSLLHIY | GYFDEEMAVK | YISEAALALD | YLHRHGIIHR |
200:
DLKPDNMLIS | NQGHIKLTDF | GLSRVTLNRE | INMIDILTTP | SMAKPKHDYS |
250:
RTPGQLLSLI | SSLGFYTPVG | MKMPINPNSG | GASDSLHEVI | SPLSMIEKEN |
300:
TPLSTKLFKT | GLDTSPLTPV | MPVRSLTPAL | LQSRERFGAS | TASSQSCMYL |
350:
SSMESECCSS | PRLEKDVKQT | EDEMCSTGTS | NSRPPLPSSR | EVLNSKDPKV |
400:
LKKELESAIS | PISSNDCGSR | QKLGTERSEI | TDTPVTTLDT | KGIVRKCLSE |
450:
NKIWEEKLVA | RREMTNEMLE | TASSQQSPLF | LKDPVQPVKE | EEIFEKPGVK |
500:
RSFELVDTSP | CQELNYVKKT | NAEYKRGCWI | SELSASKSTG | LTTEIQSLML |
550:
SGEICESKEI | MRCIDRQQTE | KPLVPTVAKN | LLCDLDADHE | KDKEYMNSSL |
600:
LCADDEKPLG | ALSADSDLSF | PETSVSESHL | EKQLVDLDKG | VKDLSFEEPK |
650:
AEDLLTMSPN | CQEASRNGVE | ADVVQNCTML | CCEQDNHQKH | TEETDTISSP |
700:
SEKMTETVHL | FRKNNVVFRS | YNSPINVSNV | SDPCSMASLD | IMDLSPACSG |
750:
SYPTAITPLQ | KTPRQGDAGT | PYRTPKSVRR | GAAPVEGERI | LGTPDYLAPE |
800:
LLLTKPHGSA | VDWWALGVCL | FEFLTGIPPF | NDETPAQVFQ | NILKRDIPWP |
850:
EGEEKLSDNA | QNAIDILLTF | DSTKRAGLKE | LKHHPLFHGV | DWDNLQNQPM |
881:
PFIPQPDDET | DTSYFEARNN | AQHLTVSGFS | L
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
Dog
Chicken
Bovine
Polyclonal Antibody for Chicken GW
Polyclonal Antibody for Chicken GW
Polyclonal Antibody for Chicken GW
Polyclonal Antibody for Chicken GW
Polyclonal Antibody for Chicken GW
Monoclonal Antibody for Chicken GW
Monoclonal Antibody for Chicken GW
Monoclonal Antibody for Chicken GW
Monoclonal Antibody for Chicken GW
Monoclonal Antibody for Chicken GW
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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more...
Nature432:695-716(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]