Gene name:
H2afy2 (H2afy3) ;
Protein name:
Core histone macro-H2A.2 (Histone macroH2A2;mH2A2) ;
Alternative:
Organism:
Mouse (Mus musculus).
General Annotation
Sub Unit:
The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.
Function:
Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.
Subcellular Location:
Nucleus
Chromosome
Enriched in inactive X chromosome chromatin and in senescence-associated heterochromatin.
Protein Attributes:
50:
MSGRSGKKKM | SKLSRSARAG | VIFPVGRLMR | YLKKGTFKYR | ISVGAPVYMA |
100:
AVIEYLAAEI | LELAGNAARD | NKKARIAPRH | ILLAVANDEE | LNQLLKGVTI |
150:
ASGGVLPRIH | PELLAKKRGT | KGKSETILSP | PPEKRGRKAA | SGKKGGKKSK |
200:
ATKPRTSKKS | KAKDSDKEGT | SNSTSEDGPG | DGFTILSSKS | LVLGQKLSLT |
250:
QSDISHIGSM | RVEGIVHPTT | AEIDLKEEIG | KALEKAGGKE | FLETVKELRK |
300:
SQGPLEVAEA | AVSQSSGLAA | KFVIHCHIPQ | WGSDKCEEQL | EETIKNCLSA |
350:
AEDKKLKSVA | FPPFPSGRNC | FPKQTAAQVT | LKAISAHFDD | SSSSSLKNVY |
372:
FLLFDSESIG | IYVQEMAKLD | TK
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Mouse
Human
ELISA Kit for Mouse Histone macroH2A2
ELISA Kit for Mouse Histone macroH2A2
CLIA Kit for Mouse Histone macroH2A2
CLIA Kit for Mouse Histone macroH2A2
Polyclonal Antibody for Mouse Histone macroH2A2
Polyclonal Antibody for Mouse Histone macroH2A2
Monoclonal Antibody for Mouse Histone macroH2A2
Monoclonal Antibody for Mouse Histone macroH2A2
Protein for Mouse Histone macroH2A2
Protein for Mouse Histone macroH2A2
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
1.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [MRNA]
strain :
C57BL/6J .
2.
"The transcriptional landscape of the mammalian genome."
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[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6J .
tissue :
Cerebellum .
3.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
strain :
C57BL/6 .
tissue :
Brain .
tissue :
Olfactory epithelium .
4.
[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s)
Cited for : TISSUE SPECIFICITY;SUBCELLULAR LOCATION