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Index > Protein center > H2afy2(Gene name) > Mouse
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  • H2afy2 (Gene name),
  • Core histone macro-H2A.2 (Protein name ),  H2AW_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    H2afy2(H2afy3);
    Protein name:
    Core histone macro-H2A.2(Histone macroH2A2;mH2A2);
    Alternative:

    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.
    Function:
    Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in stable X chromosome inactivation.
    Subcellular Location:
    Nucleus Chromosome Enriched in inactive X chromosome chromatin and in senescence-associated heterochromatin.
    Protein Attributes:
    Sequence length:
    372
    Sequence:
    50:
    MSGRSGKKKM | SKLSRSARAG | VIFPVGRLMR | YLKKGTFKYR | ISVGAPVYMA | 
    100:
    AVIEYLAAEI | LELAGNAARD | NKKARIAPRH | ILLAVANDEE | LNQLLKGVTI | 
    150:
    ASGGVLPRIH | PELLAKKRGT | KGKSETILSP | PPEKRGRKAA | SGKKGGKKSK | 
    200:
    ATKPRTSKKS | KAKDSDKEGT | SNSTSEDGPG | DGFTILSSKS | LVLGQKLSLT | 
    250:
    QSDISHIGSM | RVEGIVHPTT | AEIDLKEEIG | KALEKAGGKE | FLETVKELRK | 
    300:
    SQGPLEVAEA | AVSQSSGLAA | KFVIHCHIPQ | WGSDKCEEQL | EETIKNCLSA | 
    350:
    AEDKKLKSVA | FPPFPSGRNC | FPKQTAAQVT | LKAISAHFDD | SSSSSLKNVY | 
    372:
    FLLFDSESIG | IYVQEMAKLD | TK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    Pfam:
    UniGene:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Histone macroH2A2
    ELISA Kit for Mouse Histone macroH2A2
    CLIA Kit for Mouse Histone macroH2A2
    CLIA Kit for Mouse Histone macroH2A2
    Polyclonal Antibody for Mouse Histone macroH2A2
    Polyclonal Antibody for Mouse Histone macroH2A2
    Monoclonal Antibody for Mouse Histone macroH2A2
    Monoclonal Antibody for Mouse Histone macroH2A2
    Protein for Mouse Histone macroH2A2
    Protein for Mouse Histone macroH2A2

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant."
      Chadwick B.P. , Willard H.F.
      Hum. Mol. Genet.10:1101-1113(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      strain: C57BL/6J.
    2. 2.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6J.
      tissue: Cerebellum.
    3. 3.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      strain: C57BL/6.
      tissue: Brain.
      tissue: Olfactory epithelium.
    4. 4.
      "MACROH2A2, a new member of the MACROH2A core histone family."
      Costanzi C. , Pehrson J.R.
      J. Biol. Chem.276:21776-21784(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY;SUBCELLULAR LOCATION
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