H2afy ELISA Kit for Rat(Rattus norvegicus) | EIAab.comH2afy ELISA Kit for Rat(Rattus norvegicus)

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H2afy (Gene name),

Core histone macro-H2A.1 (Protein name ), H2AY_RAT from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

H2afy;

Protein name:

Core histone macro-H2A.1(Histone macroH2A1;mH2A1);

Alternative:

H2A/y;H2A.y;

Organism:

Rat (Rattus norvegicus).

General Annotation

Sub Unit:

The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. Interacts with SPOP. Part of a complex consisting of H2AFY, CUL3 and SPOP. Interacts with HDAC1 and HDAC2.

Function:

Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation. Inhibits the binding of transcription factors and interferes with the activity of remodeling SWI/SNF complexes. Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces an hypoacetylated state of chromatin. In addition, isoform 1, but not isoform 2, binds ADP-ribose and O-acetyl-ADP-ribose, and may be involved in ADP-ribose-mediated chromatin modulation.

Subcellular Location:

Nucleus Chromosome Enriched in inactive X chromosome chromatin and in senescence-associated heterochromatin.

Protein Attributes:

Sequence length:

371

Sequence:

50:

100:

150:

200:

250:

300:

350:

371:

VLFDSESIGI | YVQEMAKLDA | N

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

SMR:

Q02874

UniGene:

Rn.11098

String:

Q02874

Pfam:

PF00125

KEGG:

rno:29384

STRING:

10116.ENSRNOP00000049143

Uniprot:

Q02874

FOR

ELISA Kit for Rat Histone macroH2A1

CLIA Kit for Rat Histone macroH2A1

Polyclonal Antibody for Rat Histone macroH2A1

Monoclonal Antibody for Rat Histone macroH2A1

Protein for Rat Histone macroH2A1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

References

1.

"MacroH2A, a core histone containing a large nonhistone region."
Pehrson J.R. , Fried V.A.
Science257:1398-1400(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2);PARTIAL PROTEIN SEQUENCE
tissue: Liver.
2.

Pehrson J.R.
Submitted (2006-02) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SEQUENCE REVISION (ISOFORM 1)
3.

"Developmental and tissue expression patterns of histone macroH2A1 subtypes."
Pehrson J.R. , Costanzi C. , Dharia C.
J. Cell. Biochem.65:107-113(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2);TISSUE SPECIFICITY
tissue: Thymus.
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2)
strain: Brown Norway.
tissue: Kidney.
5.

"Structural characterization of the histone variant macroH2A."
Chakravarthy S. , Gundimella S.K. , Caron C. , Perche P.-Y. , Pehrson J.R. , Khochbin S. , Luger K.
Mol. Cell. Biol.25:7616-7624(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.6 ANGSTROMS) OF 181-371 (ISOFORM 1);FUNCTION

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