Protein name:
E3 ubiquitin-protein ligase HACE1 ;
Alternative:
HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1 ;
Organism:
Rat (Rattus norvegicus).
General Annotation
Sub Unit:
Interacts with RARB. Interacts with RAB1 (RAB1A, RAB1B or RAB1C), RAB4 (RAB4A or RAB4B) and RAB11 (RAB11A or RAB11B); in a GTP-dependent manner. Interacts with RAC1; in a GTP-dependent manner. Interacts with the 26S proteasomal complex through the 20S core proteasomal subunit.
Function:
E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.
Subcellular Location:
Golgi apparatus
Golgi stack membrane
Cytoplasm
Endoplasmic reticulum
A significant portion localizes to the endoplasmic reticulum. Targeted to Golgi membrane via its interaction with Rab proteins.
Protein Attributes:
50:
MERAMEQLNR | LTRSLRRART | VELPEDNETA | VYTLMPMVMA | DQHRSVSELL |
100:
SNSKFDVNYA | FGRVKRSLLH | IAANCGSVEC | LVLLLKKGAN | PNYQDISGCT |
150:
PLHLAARNGQ | KKCMSKLLEY | SADVNICNNE | GLTAIHWLAV | NGRTELLHDL |
200:
VQHVTDVDVE | DAMGQTALHV | ACQNGHKTTV | QCLLDSGADI | NRPNVAGATP |
250:
LYFACSHGQR | DTAQILLLRG | AKYLPDKNGV | TPLDLCVQGG | YGQTCEVLIQ |
300:
YHPRLFQTIV | QMTQNEDLRE | NMLRQVLQHL | SQQSESQYLK | ILTGLAEVAT |
350:
TNGHKLLSLS | SSYEAQMKSL | LRIVRIFCHV | FRIGPSSPSN | GMDMGYNGNK |
400:
TPRSQVFKPL | ELLWHSLDEW | LVLIATELMK | NKEDSADITS | ILLKQKGQDQ |
450:
EASCISAFEP | PGPGSYERLS | TGPGESKPDV | LAGKQEASAD | CQDVISVTAN |
500:
RLSAVIQAFY | MCCSCQMPPG | MTSPRFIEFV | CKHDEVLKCF | VNRNPKIIFD |
550:
HFHFLLECPE | LMSRFMHIIK | AQPFKDRCEW | FYEHLHSGQP | DSDMVHRPVS |
600:
ENDILLVHRD | SIFRSSCEIV | SKANCAKLKQ | GIAVRFHGEE | GMGQGVVREW |
650:
FDILSNEIVN | PDYALFTQSA | DGTTFQPNSN | SYVNPDHLNY | FRFAGQILGL |
700:
ALNHRQLVNI | YFTRSFYKHI | LGIPVNYQDV | ASIDPEYAKN | LQWILDNDIS |
750:
DLGLELTFSV | ETDVFGAMEE | VPLKPGGGSI | LVTQNNKAEY | VQLVTELRMT |
800:
RAIQPQINAF | LQGFHMFIPP | SLIQLFDEYE | LELLLSGMPE | IDVNDWIKNT |
850:
EYTSGYERED | PVIQWFWEVV | EDMTQEERVL | LLQFVTGSSR | VPHGGFANIM |
900:
GGSGLQNFTI | AAVPYTPNLL | PTSSTCINML | KLPEYPSKEI | LKDRLLVALH |
Vaild Sequence:
Related Databases
Uniprot:
ELISA Kit
CLIA Kit
Polyclonal Antibody
Monoclonal Antibody
Protein
FOR
Human
Chicken
Mouse
Rat
Bovine
ELISA Kit for Rat E3 ubiquitin-protein ligase HACE1
ELISA Kit for Rat E3 ubiquitin-protein ligase HACE1
ELISA Kit for Rat E3 ubiquitin-protein ligase HACE1
ELISA Kit for Rat E3 ubiquitin-protein ligase HACE1
ELISA Kit for Rat E3 ubiquitin-protein ligase HACE1
CLIA Kit for Rat E3 ubiquitin-protein ligase HACE1
CLIA Kit for Rat E3 ubiquitin-protein ligase HACE1
CLIA Kit for Rat E3 ubiquitin-protein ligase HACE1
CLIA Kit for Rat E3 ubiquitin-protein ligase HACE1
CLIA Kit for Rat E3 ubiquitin-protein ligase HACE1
Polyclonal Antibody for Rat E3 ubiquitin-protein ligase HACE1
Polyclonal Antibody for Rat E3 ubiquitin-protein ligase HACE1
Polyclonal Antibody for Rat E3 ubiquitin-protein ligase HACE1
Polyclonal Antibody for Rat E3 ubiquitin-protein ligase HACE1
Polyclonal Antibody for Rat E3 ubiquitin-protein ligase HACE1
Monoclonal Antibody for Rat E3 ubiquitin-protein ligase HACE1
Monoclonal Antibody for Rat E3 ubiquitin-protein ligase HACE1
Monoclonal Antibody for Rat E3 ubiquitin-protein ligase HACE1
Monoclonal Antibody for Rat E3 ubiquitin-protein ligase HACE1
Monoclonal Antibody for Rat E3 ubiquitin-protein ligase HACE1
Protein for Rat E3 ubiquitin-protein ligase HACE1
Protein for Rat E3 ubiquitin-protein ligase HACE1
Protein for Rat E3 ubiquitin-protein ligase HACE1
Protein for Rat E3 ubiquitin-protein ligase HACE1
Protein for Rat E3 ubiquitin-protein ligase HACE1
R&D Technical Data
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Precision
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Recovery
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Linearity
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References
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more...
Nature428:493-521(2004)
[
PubMed ]
[
Europe PMC ]
[
Abstract ]
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Cited for : NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
strain :
Brown Norway .