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Index > Protein center > Hace1(Gene name) > Rat
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  • Hace1 (Gene name),
  • E3 ubiquitin-protein ligase HACE1 (Protein name ),  HACE1_RAT from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Gene name:
    Hace1;
    Protein name:
    E3 ubiquitin-protein ligase HACE1;
    Alternative:
    HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1;
    Organism:
    Rat (Rattus norvegicus). 
    General Annotation
    Sub Unit:
    Interacts with RARB. Interacts with RAB1 (RAB1A, RAB1B or RAB1C), RAB4 (RAB4A or RAB4B) and RAB11 (RAB11A or RAB11B); in a GTP-dependent manner. Interacts with RAC1; in a GTP-dependent manner. Interacts with the 26S proteasomal complex through the 20S core proteasomal subunit.
    Function:
    E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases. Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion. Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division. Specifically interacts with GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens. May also act as a transcription regulator via its interaction with RARB.
    Subcellular Location:
    Golgi apparatus Golgi stack membrane Cytoplasm Endoplasmic reticulum A significant portion localizes to the endoplasmic reticulum. Targeted to Golgi membrane via its interaction with Rab proteins.
    Protein Attributes:
    Sequence length:
    909
    Sequence:
    50:
    MERAMEQLNR | LTRSLRRART | VELPEDNETA | VYTLMPMVMA | DQHRSVSELL | 
    100:
    SNSKFDVNYA | FGRVKRSLLH | IAANCGSVEC | LVLLLKKGAN | PNYQDISGCT | 
    150:
    PLHLAARNGQ | KKCMSKLLEY | SADVNICNNE | GLTAIHWLAV | NGRTELLHDL | 
    200:
    VQHVTDVDVE | DAMGQTALHV | ACQNGHKTTV | QCLLDSGADI | NRPNVAGATP | 
    250:
    LYFACSHGQR | DTAQILLLRG | AKYLPDKNGV | TPLDLCVQGG | YGQTCEVLIQ | 
    300:
    YHPRLFQTIV | QMTQNEDLRE | NMLRQVLQHL | SQQSESQYLK | ILTGLAEVAT | 
    350:
    TNGHKLLSLS | SSYEAQMKSL | LRIVRIFCHV | FRIGPSSPSN | GMDMGYNGNK | 
    400:
    TPRSQVFKPL | ELLWHSLDEW | LVLIATELMK | NKEDSADITS | ILLKQKGQDQ | 
    450:
    EASCISAFEP | PGPGSYERLS | TGPGESKPDV | LAGKQEASAD | CQDVISVTAN | 
    500:
    RLSAVIQAFY | MCCSCQMPPG | MTSPRFIEFV | CKHDEVLKCF | VNRNPKIIFD | 
    550:
    HFHFLLECPE | LMSRFMHIIK | AQPFKDRCEW | FYEHLHSGQP | DSDMVHRPVS | 
    600:
    ENDILLVHRD | SIFRSSCEIV | SKANCAKLKQ | GIAVRFHGEE | GMGQGVVREW | 
    650:
    FDILSNEIVN | PDYALFTQSA | DGTTFQPNSN | SYVNPDHLNY | FRFAGQILGL | 
    700:
    ALNHRQLVNI | YFTRSFYKHI | LGIPVNYQDV | ASIDPEYAKN | LQWILDNDIS | 
    750:
    DLGLELTFSV | ETDVFGAMEE | VPLKPGGGSI | LVTQNNKAEY | VQLVTELRMT | 
    800:
    RAIQPQINAF | LQGFHMFIPP | SLIQLFDEYE | LELLLSGMPE | IDVNDWIKNT | 
    850:
    EYTSGYERED | PVIQWFWEVV | EDMTQEERVL | LLQFVTGSSR | VPHGGFANIM | 
    900:
    GGSGLQNFTI | AAVPYTPNLL | PTSSTCINML | KLPEYPSKEI | LKDRLLVALH | 
    909:
    CGSYGYTMA
    3D Structure:
    N/A
    Predicted Eptitope:
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    EIAab Sequence  Vaild Sequence:
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    Related Databases
    UniGene:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Rat E3 ubiquitin-protein ligase HACE1
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    E4918h
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    96T
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    ELISA Kit for Rat E3 ubiquitin-protein ligase HACE1
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    ELISA Kit for Rat E3 ubiquitin-protein ligase HACE1
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    E4918m
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    ELISA Kit for Rat E3 ubiquitin-protein ligase HACE1
    Cat.:
    E4918r
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    Packing:
    96T
    ELISA Kit for Rat E3 ubiquitin-protein ligase HACE1
    Cat.:
    E4918b
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Rat E3 ubiquitin-protein ligase HACE1
    Cat.:
    U4918r
    Price:
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    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat E3 ubiquitin-protein ligase HACE1
    Cat.:
    U4918m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Rat E3 ubiquitin-protein ligase HACE1
    MSDS:
    Please sign in first.
    CLIA Kit for Rat E3 ubiquitin-protein ligase HACE1
    Cat.:
    U4918h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Rat E3 ubiquitin-protein ligase HACE1
    Cat.:
    U4918b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Rat E3 ubiquitin-protein ligase HACE1
    Polyclonal Antibody for Rat E3 ubiquitin-protein ligase HACE1
    Polyclonal Antibody for Rat E3 ubiquitin-protein ligase HACE1
    Cat.:
    P4918Rb-h
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Rat E3 ubiquitin-protein ligase HACE1
    Polyclonal Antibody for Rat E3 ubiquitin-protein ligase HACE1
    Cat.:
    P4918Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Rat E3 ubiquitin-protein ligase HACE1
    Monoclonal Antibody for Rat E3 ubiquitin-protein ligase HACE1
    Monoclonal Antibody for Rat E3 ubiquitin-protein ligase HACE1
    Monoclonal Antibody for Rat E3 ubiquitin-protein ligase HACE1
    Monoclonal Antibody for Rat E3 ubiquitin-protein ligase HACE1
    Protein for Rat E3 ubiquitin-protein ligase HACE1
    Protein for Rat E3 ubiquitin-protein ligase HACE1
    Protein for Rat E3 ubiquitin-protein ligase HACE1
    Protein for Rat E3 ubiquitin-protein ligase HACE1
    Protein for Rat E3 ubiquitin-protein ligase HACE1

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    References
    1. 1.
      "Genome sequence of the Brown Norway rat yields insights into mammalian evolution."
      Gibbs R.A. , Weinstock G.M. , Metzker M.L. , Muzny D.M. , Sodergren E.J. , Scherer S. , Scott G. , Steffen D. , Worley K.C. , Burch P.E. , Okwuonu G. , Hines S. , Lewis L. , Deramo C. , Delgado O. , Dugan-Rocha S. , Miner G. , Morgan M. , more...
      Nature428:493-521(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: Brown Norway.
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