HBEGF ELISA Kit for Human(Homo sapiens) | EIAab.comHBEGF ELISA Kit for Human(Homo sapiens)

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Index > Protein center > HBEGF(Gene name) > Human

HBEGF (Gene name),

Proheparin-binding EGF-like growth factor (Protein name ), HBEGF_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (1)

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Gene name:

HBEGF(DTR;DTS;HEGFL);

Protein name:

Proheparin-binding EGF-like growth factor;

Alternative:

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Function:

May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts and smooth muscle but not endothelial cells. It is able to bind EGF receptors with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.

Subcellular Location:

Proheparin-binding EGF-like growth factor Cell membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

208

Sequence:

50:

100:

150:

200:

208:

KLGMTNSH

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF00008

UniGene:

Hs.592942

STRING:

9606.ENSP00000230990

UniGene:

Hs.799

KEGG:

hsa:1839

String:

Q99075

MIM:

126150

SMR:

Q99075

Uniprot:

Q99075

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ELISA Kit for Human Proheparin-binding EGF-like growth factor

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E1479h

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96T

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ELISA Kit for Human Proheparin-binding EGF-like growth factor

Cat.:

E1479m

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ELISA Kit for Human Proheparin-binding EGF-like growth factor

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E1479p

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ELISA Kit for Human Proheparin-binding EGF-like growth factor

Cat.:

E1479r

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96T

ELISA Kit for Human Proheparin-binding EGF-like growth factor

Cat.:

E1479c

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96T

CLIA Kit for Human Proheparin-binding EGF-like growth factor

Cat.:

U1479p

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96T

CLIA Kit for Human Proheparin-binding EGF-like growth factor

Cat.:

U1479c

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Packing:

96T

CLIA Kit for Human Proheparin-binding EGF-like growth factor

Cat.:

U1479m

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Manual:

Looking for manual.

MSDS:

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Packing:

96T

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CLIA Kit for Human Proheparin-binding EGF-like growth factor

Cat.:

U1479h

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Manual:

Looking for manual.

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Packing:

96T

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CLIA Kit for Human Proheparin-binding EGF-like growth factor

Cat.:

U1479r

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Packing:

96T

Polyclonal Antibody for Human Proheparin-binding EGF-like growth factor

Cat.:

P1479Rb-r

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40ug/0.2ml

Polyclonal Antibody for Human Proheparin-binding EGF-like growth factor

Cat.:

P1479Rb-m

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40ug/0.2ml

Polyclonal Antibody for Human Proheparin-binding EGF-like growth factor

Cat.:

P1479Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human Proheparin-binding EGF-like growth factor

Monoclonal Antibody for Human Proheparin-binding EGF-like growth factor

Protein for Human Proheparin-binding EGF-like growth factor

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

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Linearity

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Citations

[1].

"ANNALS EXPRESS: Annexin A2 and its Downstream IL-6 and HB-EGF as Secretory Biomarkers in the Differential Diagnosis of Her-2 Negative Breast Cancer"

Shetty P, Patil V S, Mohan R, et al.

From:Annals of Clinical Biochemistry: An international journal of biochemistry and laboratory medicine

References

1.

"A heparin-binding growth factor secreted by macrophage-like cells that is related to EGF."
Higashiyama S. , Abraham J.A. , Miller J. , Fiddes J.C. , Klagsbrun M.
Science251:936-939(1991) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];PROTEIN SEQUENCE OF 73-93
tissue: Macrophage.
2.

NIEHS SNPs program
Submitted (2002-10) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
3.

"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
4.

"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J. , Martin J. , Terry A. , Couronne O. , Grimwood J. , Lowry S. , Gordon L.A. , Scott D. , Xie G. , Huang W. , Hellsten U. , Tran-Gyamfi M. , She X. , Prabhakar S. , Aerts A. , Altherr M. , Bajorek E. , Black S. , more...
Nature431:268-274(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
5.

Mural R.J. , Istrail S. , Sutton G.G. , Florea L. , Halpern A.L. , Mobarry C.M. , Lippert R. , Walenz B. , Shatkay H. , Dew I. , Miller J.R. , Flanigan M.J. , Edwards N.J. , Bolanos R. , Fasulo D. , Halldorsson B.V. , Hannenhalli S. , Turner R. , more...
Submitted (2005-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Eye.
7.

"Structure of heparin-binding EGF-like growth factor. Multiple forms, primary structure, and glycosylation of the mature protein."
Higashiyama S. , Lau K. , Besner G.E. , Abraham J.A. , Klagsbrun M.
J. Biol. Chem.267:6205-6212(1992) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PROTEIN SEQUENCE OF 63-141 AND 143-148;GLYCOSYLATION AT THR-75 AND THR-85
tissue: Histiocytic lymphoma.
8.

"Diphtheria toxin binds to the epidermal growth factor (EGF)-like domain of human heparin-binding EGF-like growth factor/diphtheria toxin receptor and inhibits specifically its mitogenic activity."
Mitamura T. , Higashiyama S. , Taniguchi N. , Klagsbrun M. , Mekada E.
J. Biol. Chem.270:1015-1019(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: DOMAIN TOXIN BINDING
9.

"Activation of HER4 by heparin-binding EGF-like growth factor stimulates chemotaxis but not proliferation."
Elenius K. , Paul S. , Allison G. , Sun J. , Klagsbrun M.
EMBO J.16:1268-1278(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ERBB4
10.

"ErbB and HB-EGF signaling in heart development and function."
Iwamoto R. , Mekada E.
Cell Struct. Funct.31:1-14(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW
11.

"Human urinary glycoproteomics; attachment site specific analysis of N-and O-linked glycosylations by CID and ECD."
Halim A. , Nilsson J. , Ruetschi U. , Hesse C. , Larson G.
Mol. Cell. Proteomics0:0-0(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT THR-44 AND THR-47;STRUCTURE OF CARBOHYDRATES;IDENTIFICATION BY MASS SPECTROMETRY
12.

"LC-MS/MS characterization of O-glycosylation sites and glycan structures of human cerebrospinal fluid glycoproteins."
Halim A. , Ruetschi U. , Larson G. , Nilsson J.
J. Proteome Res.12:573-584(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: GLYCOSYLATION AT THR-37; SER-38 AND THR-44;IDENTIFICATION BY MASS SPECTROMETRY
13.

"Crystal structure of the complex of diphtheria toxin with an extracellular fragment of its receptor."
Louie G.V. , Yang W. , Bowman M.E. , Choe S.
Mol. Cell1:67-78(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.65 ANGSTROMS) OF 73-147 IN COMPLEX WITH TOX

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