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Index > Protein center > HSD17B10(Gene name) > Human
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  • HSD17B10 (Gene name),
  • 3-hydroxyacyl-CoA dehydrogenase type-2 (Protein name ),  HCD2_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    HSD17B10(ERAB;HADH2;MRPP2;SCHAD;XH98G2);
    Protein name:
    3-hydroxyacyl-CoA dehydrogenase type-2;
    Alternative:
    1.1.1.178;3-hydroxy-2-methylbutyryl-CoA dehydrogenase);1.1.1.51;17-beta-hydroxysteroid dehydrogenase 10(17-beta-HSD 10);Endoplasmic reticulum-associated amyloid beta-peptide-binding protein;3-hydroxyacyl-CoA dehydrogenase type II;Short-chain type dehydrogenase/reductase XH98G2;Mitochondrial ribonuclease P protein 2(Mitochondrial RNase P protein 2);Type II HADH;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Homotetramer (By similarity). Interacts with MRPP1/RG9MTD1 and MRPP3/KIAA0391.
    Function:
    Functions in mitochondrial tRNA maturation. Part of mitochondrial ribonuclease P, an enzyme composed of MRPP1/RG9MTD1, MRPP2/HSD17B10 and MRPP3/KIAA0391, which cleaves tRNA molecules in their 5'-ends. By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD).
    Subcellular Location:
    Mitochondrion
    Protein Attributes:
    Sequence length:
    261
    Sequence:
    50:
    MAAACRSVKG | LVAVITGGAS | GLGLATAERL | VGQGASAVLL | DLPNSGGEAQ | 
    100:
    AKKLGNNCVF | APADVTSEKD | VQTALALAKG | KFGRVDVAVN | CAGIAVASKT | 
    150:
    YNLKKGQTHT | LEDFQRVLDV | NLMGTFNVIR | LVAGEMGQNE | PDQGGQRGVI | 
    200:
    INTASVAAFE | GQVGQAAYSA | SKGGIVGMTL | PIARDLAPIG | IRVMTIAPGL | 
    250:
    FGTPLLTSLP | EKVCNFLASQ | VPFPSRLGDP | AEYAHLVQAI | IENPFLNGEV | 
    261:
    IRLDGAIRMQ | P
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    Pfam:
    MIM:
    SMR:
    String:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Human 3-hydroxyacyl-CoA dehydrogenase type-2
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    E5607h
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    ELISA Kit for Human 3-hydroxyacyl-CoA dehydrogenase type-2
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    ELISA Kit for Human 3-hydroxyacyl-CoA dehydrogenase type-2
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    ELISA Kit for Human 3-hydroxyacyl-CoA dehydrogenase type-2
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    CLIA Kit for Human 3-hydroxyacyl-CoA dehydrogenase type-2
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    CLIA Kit for Human 3-hydroxyacyl-CoA dehydrogenase type-2
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    Packing:
    96T
    CLIA Kit for Human 3-hydroxyacyl-CoA dehydrogenase type-2
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    U5607r
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    CLIA Kit for Human 3-hydroxyacyl-CoA dehydrogenase type-2
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    Polyclonal Antibody for Human 3-hydroxyacyl-CoA dehydrogenase type-2
    Polyclonal Antibody for Human 3-hydroxyacyl-CoA dehydrogenase type-2
    Polyclonal Antibody for Human 3-hydroxyacyl-CoA dehydrogenase type-2
    Cat.:
    P5607Rb-m
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human 3-hydroxyacyl-CoA dehydrogenase type-2
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    P5607Rb-h
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    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human 3-hydroxyacyl-CoA dehydrogenase type-2
    Monoclonal Antibody for Human 3-hydroxyacyl-CoA dehydrogenase type-2
    Monoclonal Antibody for Human 3-hydroxyacyl-CoA dehydrogenase type-2
    Monoclonal Antibody for Human 3-hydroxyacyl-CoA dehydrogenase type-2
    Protein for Human 3-hydroxyacyl-CoA dehydrogenase type-2
    Protein for Human 3-hydroxyacyl-CoA dehydrogenase type-2
    Protein for Human 3-hydroxyacyl-CoA dehydrogenase type-2
    Protein for Human 3-hydroxyacyl-CoA dehydrogenase type-2

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    References
    1. 1.
      "An intracellular protein that binds amyloid-beta peptide and mediates neurotoxicity in Alzheimer's disease."
      Yan S.D. , Fu J. , Soto C. , Chen X. , Zhu H. , Al-Mohanna F. , Collinson K. , Zhu A. , Stern E. , Saido T. , Tohyama M. , Ogawa S. , Roher A. , Stern D.
      Nature389:689-695(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);FUNCTION;TISSUE SPECIFICITY
      tissue: Brain.
    2. 2.
      Zhuchenko O.P. , Wehnert M. , Bailey J. , Sun Z.S. , Lee C.C.
      Submitted (1997-01) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    3. 3.
      "Chromosomal basis of X chromosome inactivation: identification of a multigene domain in Xp11.21-p11.22 that escapes X inactivation."
      Miller A.P. , Willard H.F.
      Proc. Natl. Acad. Sci. U.S.A.95:8709-8714(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    4. 4.
      "A human brain L-3-hydroxyacyl-coenzyme A dehydrogenase is identical to an amyloid beta-peptide-binding protein involved in Alzheimer's disease."
      He X.Y. , Schulz H. , Yang S.Y.
      J. Biol. Chem.273:10741-10746(1998) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA] (ISOFORM 1);CATALYTIC ACTIVITY
      tissue: Brain.
    5. 5.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
    6. 6.
      "The DNA sequence of the human X chromosome."
      Ross M.T. , Grafham D.V. , Coffey A.J. , Scherer S. , McLay K. , Muzny D. , Platzer M. , Howell G.R. , Burrows C. , Bird C.P. , Frankish A. , Lovell F.L. , Howe K.L. , Ashurst J.L. , Fulton R.S. , Sudbrak R. , Wen G. , Jones M.C. , more...
      Nature434:325-337(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Brain.
      tissue: Lung.
    9. 9.
      "Expression, release and induction of endoplasmic reticulum-associated amyloid beta-binding protein in brain disease."
      Deininger M.H. , Meyermann R. , Schluesener H.J.
      Submitted (2002-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 51-246
    10. 10.
      "Expanded substrate screenings of human and Drosophila type 10 17beta-hydroxysteroid dehydrogenases (HSDs) reveal multiple specificities in bile acid and steroid hormone metabolism: characterization of multifunctional 3alpha/7alpha/7beta/17beta/20beta/21-HSD."
      Shafqat N. , Marschall H.U. , Filling C. , Nordling E. , Wu X.Q. , Bjork L. , Thyberg J. , Martensson E. , Salim S. , Jornvall H. , Oppermann U.
      Biochem. J.376:49-60(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;CATALYTIC ACTIVITY;BIOPHYSICOCHEMICAL PROPERTIES;SUBCELLULAR LOCATION
    11. 11.
      "The reduced expression of the HADH2 protein causes X-linked mental retardation, choreoathetosis, and abnormal behavior."
      Lenski C. , Kooy R.F. , Reyniers E. , Loessner D. , Wanders R.J.A. , Winnepenninckx B. , Hellebrand H. , Engert S. , Schwartz C.E. , Meindl A. , Ramser J.
      Am. J. Hum. Genet.80:372-377(2007) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN MRXS10
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN MRX17
    13. 13.
      "RNase P without RNA: identification and functional reconstitution of the human mitochondrial tRNA processing enzyme."
      Holzmann J. , Frank P. , Loeffler E. , Bennett K.L. , Gerner C. , Rossmanith W.
      Cell135:462-474(2008) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;FUNCTION;INTERACTION WITH KIAA0391 AND TRMT10C;SUBCELLULAR LOCATION
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    15. 15.
      "Crystal structure of human ABAD/HSD10 with a bound inhibitor: implications for design of Alzheimer's disease therapeutics."
      Kissinger C.R. , Rejto P.A. , Pelletier L.A. , Thomson J.A. , Showalter R.E. , Abreo M.A. , Agree C.S. , Margosiak S. , Meng J.J. , Aust R.M. , Vanderpool D. , Li B. , Tempczyk-Russell A. , Villafranca J.E.
      J. Mol. Biol.342:943-952(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.0 ANGSTROMS) IN COMPLEX WITH NAD
    16. 16.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.3 ANGSTROMS)
    17. 17.
      "2-methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency is caused by mutations in the HADH2 gene."
      Ofman R. , Ruiter J.P.N. , Feenstra M. , Duran M. , Poll-The B.T. , Zschocke J. , Ensenauer R. , Lehnert W. , Sass J.O. , Sperl W. , Wanders R.J.A.
      Am. J. Hum. Genet.72:1300-1307(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MHBD DEFICIENCY VAL-122 AND CYS-130
    18. 18.
      "2-methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency: an X-linked inborn error of isoleucine metabolism that may mimic a mitochondrial disease."
      Perez-Cerda C. , Garcia-Villoria J. , Ofman R. , Sala P.R. , Merinero B. , Ramos J. , Garcia-Silva M.T. , Beseler B. , Dalmau J. , Wanders R.J.A. , Ugarte M. , Ribes A.
      Pediatr. Res.58:488-491(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MHBD DEFICIENCY CYS-130 AND SER-247;CHARACTERIZATION OF VARIANT MHBD DEFICIENCY SER-247
    19. 19.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ERRATUM
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