Hdac1 ELISA Kit for Mouse(Mus musculus) | EIAab.comHdac1 ELISA Kit for Mouse(Mus musculus)

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Hdac1 (Gene name),

Histone deacetylase 1 (Protein name ), HDAC1_MOUSE from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

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Gene name:

Hdac1;

Protein name:

Histone deacetylase 1(HD1);

Alternative:

Organism:

Mouse (Mus musculus).

General Annotation

Sub Unit:

Part of the core histone deacetylase (HDAC) complex composed of HDAC1, HDAC2, RBBP4 and RBBP7. The core complex associates with MTA2, MBD2, MBD3, MTA1L1, CHD3 and CHD4 to form the nucleosome remodeling and histone deacetylation (NuRD) complex, or with SIN3, SAP18 and SAP30 to form the SIN3 HDAC complex. Component of a BHC histone deacetylase complex that contains HDAC1, HDAC2, HMG20B/BRAF35, KDM1A, RCOR1/CoREST and PHF21A/BHC80. The BHC complex may also contain ZMYM2, ZNF217, ZMYM3, GSE1 and GTF2I. Associates with the 9-1-1 complex; interacts with HUS1. Found in a complex with DNMT3A and HDAC7. Interacts with BAZ2A/TIP5, BCOR, BRMS1L, DAXX, DNMT1, EP300, HCFC1, NFE4, PCAF, PHB2, MIER1, KDM4A, MINT, NRIP1, PRDM6, RERE, SETDB1, SMYD2, SUV39H1, TGIF, TGIF2, UHRF1, UHRF2 and ZNF541. Interacts with the non-histone region of H2AFY. Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3/SAP45, ARID4B/SAP180, HDAC1 and HDAC2. Interacts with KDM5B and BRMS1. Interacts with TRIM28; the interaction recruits HDAC1 to E2F1 and inhibits its acetylation (By similarity). Interacts with BANP and CBFA2T3. Interacts with SAP30L and KLF1. Interacts with E4F1. Interacts with CHFR, PRDM16, SP1, SP3, and SMAD3. Interacts with RB1 and SMARCA4/BRG1. Interacts with TRAF6. Interacts with TSHZ3 (via N-terminus); the interaction is direct. Found in a trimeric complex with APBB1 and TSHZ3; the interaction between HDAC1 and APBB1 is mediated by TSHZ3. Interacts with APEX1; the interaction is not dependent on the acetylated status of APEX1 (By similarity). Interacts with NR4A2/NURR1. Interacts with SAMSN1. Interacts with C10orf90/FATS (via its N-terminal); the interaction prevents binding of HDAC1 to CDKN1A/p21 and facilitates the acetylation and stabilization of CDKN1A/p21. Interacts with CDKN1A/p21; the interaction is prevented by binding of C10orf90/FATS facilitating acetylation and stabilization of CDKN1A/p21. Binds to CDK5 complexed to CDK5R1 (p25).

Function:

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Deacetylates SP proteins, SP1 and SP3, and regulates their function. Component of the BRG1-RB1-HDAC1 complex, which negatively regulates the CREST-mediated transcription in resting neurons. Upon calcium stimulation, HDAC1 is released from the complex and CREBBP is recruited, which facilitates transcriptional activation. Deacetylates TSHZ3 and regulates its transcriptional repressor activity. Deacetylates 'Lys-310' in RELA and thereby inhibits the transcriptional activity of NF-kappa-B.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

482

Sequence:

50:

100:

150:

200:

250:

300:

350:

400:

450:

482:

KDPEEKKEVT | EEEKTKEEKP | EAKGVKEEVK | LA

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

O09106

SMR:

O09106

KEGG:

mmu:433759

Pfam:

PF00850

UniGene:

Mm.202504

Uniprot:

O09106

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ELISA Kit for Mouse HD1

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E0883m

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ELISA Kit for Mouse HD1

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E0883h

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96T

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ELISA Kit for Mouse HD1

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E0883r

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ELISA Kit for Mouse HD1

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E0883b

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ELISA Kit for Mouse HD1

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E0883c

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96T

CLIA Kit for Mouse HD1

Cat.:

U0883b

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96T

CLIA Kit for Mouse HD1

Cat.:

U0883h

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96T

CLIA Kit for Mouse HD1

Cat.:

U0883r

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96T

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CLIA Kit for Mouse HD1

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U0883m

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96T

CLIA Kit for Mouse HD1

Cat.:

U0883c

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96T

Polyclonal Antibody for Mouse HD1

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P0883Rb-r

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40ug/0.2ml

Polyclonal Antibody for Mouse HD1

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P0883Rb-m

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Polyclonal Antibody for Mouse HD1

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P0883Rb-h

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Monoclonal Antibody for Mouse HD1

Protein for Mouse HD1

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Identification of mouse histone deacetylase 1 as a growth factor-inducible gene."
Bartl S. , Taplick J. , Lagger G. , Khier H. , Kuchler K. , Seiser C.
Mol. Cell. Biol.17:5033-5043(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
tissue: Fibroblast.
2.

Johnson C.A.
Submitted (1997-09) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
3.

"SAP30, a component of the mSin3 corepressor complex involved in N-CoR-mediated repression by specific transcription factors."
Laherty C.D. , Billin A.N. , Lavinsky R.M. , Yochum G.S. , Bush A.C. , Sun J.-M. , Mullen T.-M. , Davie J.R. , Rose D.W. , Glass C.K. , Rosenfeld M.G. , Ayer D.E. , Eisenman R.N.
Mol. Cell2:33-42(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SAP30
4.

"DNA methyltransferase Dnmt1 associates with histone deacetylase activity."
Fuks F. , Burgers W.A. , Brehm A. , Hughes-Davies L. , Kouzarides T.
Nat. Genet.24:88-91(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DNMT1
5.

"Identification of a nuclear domain with deacetylase activity."
Downes M. , Ordentlich P. , Kao H.-Y. , Alvarez J.G.A. , Evans R.M.
Proc. Natl. Acad. Sci. U.S.A.97:10330-10335(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HDAC7
6.

"Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor."
Zhang C.L. , McKinsey T.A. , Lu J.R. , Olson E.N.
J. Biol. Chem.276:35-39(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HDAC9
7.

"ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain."
Amann J.M. , Nip J. , Strom D.K. , Lutterbach B. , Harada H. , Lenny N. , Downing J.R. , Meyers S. , Hiebert S.W.
Mol. Cell. Biol.21:6470-6483(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CBFA2T3
8.

"The chromatin remodeling complex NoRC targets HDAC1 to the ribosomal gene promoter and represses RNA polymerase I transcription."
Zhou Y. , Santoro R. , Grummt I.
EMBO J.21:4632-4640(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BAZ2A
9.

"Identification of mammalian Sds3 as an integral component of the Sin3/histone deacetylase corepressor complex."
Alland L. , David G. , Shen-Li H. , Potes J. , Muhle R. , Lee H.-C. , Hou H. Jr. , Chen K. , DePinho R.A.
Mol. Cell. Biol.22:2743-2750(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SIN3B
10.

"Functional and physical interaction between the histone methyl transferase Suv39H1 and histone deacetylases."
Vaute O. , Nicolas E. , Vandel L. , Trouche D.
Nucleic Acids Res.30:475-481(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SUV39H1
11.

"An ERG (ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors mSin3A/B."
Yang L. , Mei Q. , Zielinska-Kwiatkowska A. , Matsui Y. , Blackburn M.L. , Benedetti D. , Krumm A.A. , Taborsky G.J. Jr. , Chansky H.A.
Biochem. J.369:651-657(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SETDB1
12.

"Biochemical fractionation reveals association of DNA methyltransferase (Dnmt) 3b with Dnmt1 and that of Dnmt 3a with a histone H3 methyltransferase and Hdac1."
Datta J. , Ghoshal K. , Sharma S.M. , Tajima S. , Jacob S.T.
J. Cell. Biochem.88:855-864(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A COMPLEX WITH DNMT3A
13.

"Atrophin 2 recruits histone deacetylase and is required for the function of multiple signaling centers during mouse embryogenesis."
Zoltewicz J.S. , Stewart N.J. , Leung R. , Peterson A.S.
Development131:3-14(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RERE
14.

"Transcriptional regulation by the repressor of estrogen receptor activity via recruitment of histone deacetylases."
Kurtev V. , Margueron R. , Kroboth K. , Ogris E. , Cavailles V. , Seiser C.
J. Biol. Chem.279:24834-24843(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PHB2
15.

"Circadian and light-induced transcription of clock gene Per1 depends on histone acetylation and deacetylation."
Naruse Y. , Oh-hashi K. , Iijima N. , Naruse M. , Yoshioka H. , Tanaka M.
Mol. Cell. Biol.24:6278-6287(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION IN CIRCADIAN CLOCK;INTERACTION WITH CRY1
16.

"Stage-specific repression by the EKLF transcriptional activator."
Chen X. , Bieker J.J.
Mol. Cell. Biol.24:10416-10424(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH KLF1;FUNCTION
17.

"Multiple domains of the receptor-interacting protein 140 contribute to transcription inhibition."
Castet A. , Boulahtouf A. , Versini G. , Bonnet S. , Augereau P. , Vignon F. , Khochbin S. , Jalaguier S. , Cavailles V.
Nucleic Acids Res.32:1957-1966(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NRIP1
18.

"The PHD finger/bromodomain of NoRC interacts with acetylated histone H4K16 and is sufficient for rDNA silencing."
Zhou Y. , Grummt I.
Curr. Biol.15:1434-1438(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BAZ2A
19.

"Structural characterization of the histone variant macroH2A."
Chakravarthy S. , Gundimella S.K. , Caron C. , Perche P.-Y. , Pehrson J.R. , Khochbin S. , Luger K.
Mol. Cell. Biol.25:7616-7624(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH H2AFY
20.

"Tumor suppressor SMAR1 mediates cyclin D1 repression by recruitment of the SIN3/histone deacetylase 1 complex."
Rampalli S. , Pavithra L. , Bhatt A. , Kundu T.K. , Chattopadhyay S.
Mol. Cell. Biol.25:8415-8429(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BANP
21.

"Histone deacetylase 9 couples neuronal activity to muscle chromatin acetylation and gene expression."
Mejat A. , Ramond F. , Bassel-Duby R. , Khochbin S. , Olson E.N. , Schaeffer L.
Nat. Neurosci.8:313-321(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HDAC9;TISSUE SPECIFICITY
22.

"Identification and characterization of Smyd2: a split SET/MYND domain-containing histone H3 lysine 36-specific methyltransferase that interacts with the Sin3 histone deacetylase complex."
Brown M.A. , Sims R.J. III , Gottlieb P.D. , Tucker P.W.
Mol. Cancer5:26-26(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SMYD2
23.

"PRISM/PRDM6, a transcriptional repressor that promotes the proliferative gene program in smooth muscle cells."
Davis C.A. , Haberland M. , Arnold M.A. , Sutherland L.B. , McDonald O.G. , Richardson J.A. , Childs G. , Harris S. , Owens G.K. , Olson E.N.
Mol. Cell. Biol.26:2626-2636(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PRDM6
24.

"Neuroprotection by histone deacetylase-related protein."
Morrison B.E. , Majdzadeh N. , Zhang X. , Lyles A. , Bassel-Duby R. , Olson E.N. , D'Mello S.R.
Mol. Cell. Biol.26:3550-3564(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HDAC9
25.

"Epigenetic regulation of hematopoietic differentiation by Gfi-1 and Gfi-1b is mediated by the cofactors CoREST and LSD1."
Saleque S. , Kim J. , Rooke H.M. , Orkin S.H.
Mol. Cell27:562-572(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY AS A COMPONENT OF A GFI-RCOR-KDM1A-HDAC COMPLEX;INTERACTION WITH GFI1 AND GFI1B;FUNCTION
26.

"A novel germ cell-specific protein, SHIP1, forms a complex with chromatin remodeling activity during spermatogenesis."
Choi E. , Han C. , Park I. , Lee B. , Jin S. , Choi H. , Kim do H. , Park Z.Y. , Eddy E.M. , Cho C.
J. Biol. Chem.283:35283-35294(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ZNF541
27.

"Pitx3 potentiates Nurr1 in dopamine neuron terminal differentiation through release of SMRT-mediated repression."
Jacobs F.M. , van Erp S. , van der Linden A.J. , von Oerthel L. , Burbach J.P. , Smidt M.P.
Development136:531-540(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH NR4A2
28.

"SLy2 targets the nuclear SAP30/HDAC1 complex."
Brandt S. , Ellwanger K. , Beuter-Gunia C. , Schuster M. , Hausser A. , Schmitz I. , Beer-Hammer S.
Int. J. Biochem. Cell Biol.42:1472-1481(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH SAMSN1
29.

"Glucocorticoid-induced leucine zipper (GILZ) and long GILZ inhibit myogenic differentiation and mediate anti-myogenic effects of glucocorticoids."
Bruscoli S. , Donato V. , Velardi E. , Di Sante M. , Migliorati G. , Donato R. , Riccardi C.
J. Biol. Chem.285:10385-10396(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH TSC22D3
strain: DBA/2.
tissue: Myoblast.
30.

"Zmynd15 encodes a histone deacetylase-dependent transcriptional repressor essential for spermiogenesis and male fertility."
Yan W. , Si Y. , Slaymaker S. , Li J. , Zheng H. , Young D.L. , Aslanian A. , Saunders L. , Verdin E. , Charo I.F.
J. Biol. Chem.285:31418-31426(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ZMYND15
31.

"An HDAC1-binding domain within FATS bridges p21 turnover to radiation-induced tumorigenesis."
Li Z. , Zhang Q. , Mao J.H. , Weise A. , Mrasek K. , Fan X. , Zhang X. , Liehr T. , Lu K.H. , Balmain A. , Cai W.W.
Oncogene29:2659-2671(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH C10ORF90/FATS AND CDKN1A/P21
32.

"Stress-induced C/EBP homology protein (CHOP) represses MyoD transcription to delay myoblast differentiation."
Alter J. , Bengal E.
PLoS ONE6:E29498-E29498(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DDIT3
33.

"A novel KRAB domain-containing zinc finger transcription factor ZNF431 directly represses Patched1 transcription."
He Z. , Cai J. , Lim J.W. , Kroll K. , Ma L.
J. Biol. Chem.286:7279-7289(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ZNF431
34.

"Histone lysine demethylase JARID1a activates CLOCK-BMAL1 and influences the circadian clock."
DiTacchio L. , Le H.D. , Vollmers C. , Hatori M. , Witcher M. , Secombe J. , Panda S.
Science333:1881-1885(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH KDM5A
35.

"Insm1 controls development of pituitary endocrine cells and requires a SNAG domain for function and for recruitment of histone-modifying factors."
Welcker J.E. , Hernandez-Miranda L.R. , Paul F.E. , Jia S. , Ivanov A. , Selbach M. , Birchmeier C.
Development140:4947-4958(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH INSM1
36.

"Temporal orchestration of repressive chromatin modifiers by circadian clock Period complexes."
Duong H.A. , Weitz C.J.
Nat. Struct. Mol. Biol.21:126-132(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION IN A LARGE PER COMPLEX
37.

"A novel protein, CHRONO, functions as a core component of the mammalian circadian clock."
Goriki A. , Hatanaka F. , Myung J. , Kim J.K. , Yoritaka T. , Tanoue S. , Abe T. , Kiyonari H. , Fujimoto K. , Kato Y. , Todo T. , Matsubara A. , Forger D. , Takumi T.
PLoS Biol.12:E1001839-E1001839(2014) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH CIART

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