HERC5 ELISA Kit for Human(Homo sapiens) | EIAab.comHERC5 ELISA Kit for Human(Homo sapiens) | EIAab.com

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HERC5 (Gene name),

E3 ISG15--protein ligase HERC5 (Protein name ), HERC5_HUMAN from NCBI database.

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General Annotation

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Antigen Annotation

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3D

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Predicted Eptitope

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Vaild Sequence

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Related Databases

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Gene name:

HERC5(CEB1;CEBP1);

Protein name:

E3 ISG15--protein ligase HERC5;

Alternative:

HECT domain and RCC1-like domain-containing protein 5;Cyclin-E-binding protein 1;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Binds to CCNA1, CCNB1, CCND1 and CCNE1. Interacts with UBE2L6. Interacts with IRF3, this interaction is marginal in resting cells but enhanced upon viral infection.

Function:

Major E3 ligase for ISG15 conjugation. Acts as a positive regulator of innate antiviral response in cells induced by interferon. Makes part of the ISGylation machinery that recognizes target proteins in a broad and relatively non-specific manner. Catalyzes ISGylation of IRF3 which results in sustained activation, it attenuates IRF3-PIN1 interaction, which antagonizes IRF3 ubiquitination and degradation, and boosts the antiviral response. Catalyzes ISGylation of influenza A viral NS1 which attenuates virulence; ISGylated NS1 fails to form homodimers and thus to interact with its RNA targets. Catalyzes ISGylation of papillomavirus type 16 L1 protein which results in dominant-negative effect on virus infectivity. Physically associated with polyribosomes, broadly modifies newly synthesized proteins in a cotranslational manner. In an interferon-stimulated cell, newly translated viral proteins are primary targets of ISG15.

Subcellular Location:

Cytoplasm perinuclear region Associated with the polyribosomes, probably via the 60S subunit.

Protein Attributes:

Sequence length:

1024

Sequence:

50:

MERRSRRKSR | RNGRSTAGKA | AATQPAKSPG | AQLWLFPSAA | GLHRALLRRV |

100:

EVTRQLCCSP | GRLAVLERGG | AGVQVHQLLA | GSGGARTPKC | IKLGKNMKIH |

150:

SVDQGAEHML | ILSSDGKPFE | YDNYSMKHLR | FESILQEKKI | IQITCGDYHS |

200:

LALSKGGELF | AWGQNLHGQL | GVGRKFPSTT | TPQIVEHLAG | VPLAQISAGE |

250:

AHSMALSMSG | NIYSWGKNEC | GQLGLGHTES | KDDPSLIEGL | DNQKVEFVAC |

300:

GGSHSALLTQ | DGLLFTFGAG | KHGQLGHNST | QNELRPCLVA | ELVGYRVTQI |

350:

ACGRWHTLAY | VSDLGKVFSF | GSGKDGQLGN | GGTRDQLMPL | PVKVSSSEEL |

400:

KLESHTSEKE | LIMIAGGNQS | ILLWIKKENS | YVNLKRTIPT | LNEGTVKRWI |

450:

ADVETKRWQS | TKREIQEIFS | SPACLTGSFL | RKRRTTEMMP | VYLDLNKARN |

500:

IFKELTQKDW | ITNMITTCLK | DNLLKRLPFH | SPPQEALEIF | FLLPECPMMH |

550:

ISNNWESLVV | PFAKVVCKMS | DQSSLVLEEY | WATLQESTFS | KLVQMFKTAV |

600:

ICQLDYWDES | AEENGNVQAL | LEMLKKLHRV | NQVKCQLPES | IFQVDELLHR |

650:

LNFFVEVCRR | YLWKMTVDAS | ENVQCCVIFS | HFPFIFNNLS | KIKLLHTDTL |

700:

LKIESKKHKA | YLRSAAIEEE | RESEFALRPT | FDLTVRRNHL | IEDVLNQLSQ |

750:

FENEDLRKEL | WVSFSGEIGY | DLGGVKKEFF | YCLFAEMIQP | EYGMFMYPEG |

800:

ASCMWFPVKP | KFEKKRYFFF | GVLCGLSLFN | CNVANLPFPL | ALFKKLLDQM |

850:

PSLEDLKELS | PDLGKNLQTL | LDDEGDNFEE | VFYIHFNVHW | DRNDTNLIPN |

900:

GSSITVNQTN | KRDYVSKYIN | YIFNDSVKAV | YEEFRRGFYK | MCDEDIIKLF |

950:

HPEELKDVIV | GNTDYDWKTF | EKNARYEPGY | NSSHPTIVMF | WKAFHKLTLE |

1000:

EKKKFLVFLT | GTDRLQMKDL | NNMKITFCCP | ESWNERDPIR | ALTCFSVLFL |

1024:

PKYSTMETVE | EALQEAINNN | RGFG

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

String:

STRING:

9606.ENSP00000264350

KEGG:

Pfam:

UniGene:

SMR:

MIM:

Uniprot:

FOR

ELISA Kit for Human E3 ISG15--protein ligase HERC5

CLIA Kit for Human E3 ISG15--protein ligase HERC5

Polyclonal Antibody for Human E3 ISG15--protein ligase HERC5

Monoclonal Antibody for Human E3 ISG15--protein ligase HERC5

Protein for Human E3 ISG15--protein ligase HERC5

R&D Technical Data

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For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

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Precision

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Recovery

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Linearity

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References

1.

"A novel human gene encoding HECT domain and RCC1-like repeats interacts with cyclins and is potentially regulated by the tumor suppressor proteins."
Mitsui K. , Nakanishi M. , Ohtsuka S. , Norwood T.H. , Okabayashi K. , Miyamoto C. , Tanaka K. , Yoshimura A. , Ohtsubo M.
Biochem. Biophys. Res. Commun.266:115-122(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];TISSUE SPECIFICITY;INTERACTION WITH CCNA1; CCNB1; CCND1 AND CCNE1
tissue: Embryonic kidney.
2.

"HERC5, a HECT E3 ubiquitin ligase tightly regulated in LPS activated endothelial cells."
Kroismayr R. , Baranyi U. , Stehlik C. , Dorfleutner A. , Binder B.R. , Lipp J.
J. Cell Sci.117:4749-4756(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];MUTAGENESIS OF CYS-994;TISSUE SPECIFICITY;INDUCTION
3.

"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."
Hillier L.W. , Graves T.A. , Fulton R.S. , Fulton L.A. , Pepin K.H. , Minx P. , Wagner-McPherson C. , Layman D. , Wylie K. , Sekhon M. , Becker M.C. , Fewell G.A. , Delehaunty K.D. , Miner T.L. , Nash W.E. , Kremitzki C. , Oddy L. , Du H. , more...
Nature434:724-731(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
tissue: Brain.
5.

"Identification and Herc5-mediated ISGylation of novel target proteins."
Takeuchi T. , Inoue S. , Yokosawa H.
Biochem. Biophys. Res. Commun.348:473-477(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION
6.

"Herc5, an interferon-induced HECT E3 enzyme, is required for conjugation of ISG15 in human cells."
Dastur A. , Beaudenon S. , Kelley M. , Krug R.M. , Huibregtse J.M.
J. Biol. Chem.281:4334-4338(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF CYS-994
7.

"HERC5 is an IFN-induced HECT-type E3 protein ligase that mediates type I IFN-induced ISGylation of protein targets."
Wong J.J. , Pung Y.F. , Sze N.S. , Chin K.C.
Proc. Natl. Acad. Sci. U.S.A.103:10735-10740(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF CYS-994;ISGYLATION;INDUCTION BY IFNB1;INTERACTION WITH ISGYLATED HSPA8 AND TXNRD1
8.

"Herc5 attenuates influenza A virus by catalyzing ISGylation of viral NS1 protein."
Tang Y. , Zhong G. , Zhu L. , Liu X. , Shan Y. , Feng H. , Bu Z. , Chen H. , Wang C.
J. Immunol.184:5777-5790(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF CYS-994
9.

"Positive regulation of interferon regulatory factor 3 activation by Herc5 via ISG15 modification."
Shi H.X. , Yang K. , Liu X. , Liu X.Y. , Wei B. , Shan Y.F. , Zhu L.H. , Wang C.
Mol. Cell. Biol.30:2424-2436(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;MUTAGENESIS OF CYS-994;INTERACTION WITH IRF3
10.

"The ISG15 conjugation system broadly targets newly synthesized proteins: implications for the antiviral function of ISG15."
Durfee L.A. , Lyon N. , Seo K. , Huibregtsesend J.M.
Mol. Cell38:722-732(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;SUBCELLULAR LOCATION;INTERACTION WITH 60S SUBUNIT;MUTAGENESIS OF CYS-994
11.

"ISG15 conjugation system targets the viral NS1 protein in influenza A virus-infected cells."
Zhao C. , Hsiang T.Y. , Kuo R.L. , Krug R.M.
Proc. Natl. Acad. Sci. U.S.A.107:2253-2258(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH INFLUENZA A VIRUS NS1

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