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Index > Protein center > HERPUD1(Gene name) > Human
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  • HERPUD1 (Gene name),
  • Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (Protein name ),  HERP1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    HERPUD1(HERP;KIAA0025;MIF1);
    Protein name:
    Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein;
    Alternative:
    Methyl methanesulfonate (MMF)-inducible fragment protein 1;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Interacts with PSEN1 and PSEN2. Interacts with SYVN1 and UBXN6.
    Function:
    Component of the endoplasmic reticulum quality control (ERQC) system also called ER-associated degradation (ERAD) involved in ubiquitin-dependent degradation of misfolded endoplasmic reticulum proteins. Could enhance presenilin-mediated beta-amyloid protein 40 generation.
    Subcellular Location:
    Endoplasmic reticulum membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    391
    Sequence:
    50:
    MESETEPEPV | TLLVKSPNQR | HRDLELSGDR | GWSVGHLKAH | LSRVYPERPR | 
    100:
    PEDQRLIYSG | KLLLDHQCLR | DLLPKQEKRH | VLHLVCNVKS | PSKMPEINAK | 
    150:
    VAESTEEPAG | SNRGQYPEDS | SSDGLRQREV | LRNLSSPGWE | NISRPEAAQQ | 
    200:
    AFQGLGPGFS | GYTPYGWLQL | SWFQQIYARQ | YYMQYLAATA | ASGAFVPPPS | 
    250:
    AQEIPVVSAP | APAPIHNQFP | AENQPANQNA | APQVVVNPGA | NQNLRMNAQG | 
    300:
    GPIVEEDDEI | NRDWLDWTYS | AATFSVFLSI | LYFYSSLSRF | LMVMGATVVM | 
    350:
    YLHHVGWFPF | RPRPVQNFPN | DGPPPDVVNQ | DPNNNLQEGT | DPETEDPNHL | 
    391:
    PPDRDVLDGE | QTSPSFMSTA | WLVFKTFFAS | LLPEGPPAIA | N
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    MIM:
    KEGG:
    UniGene:
    SMR:
    String:
    Pfam:
    Uniprot:
     
    FOR
    ELISA Kit for Human Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
    Cat.:
    E11526h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
    Cat.:
    E11526m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
    Cat.:
    U11526h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
    Cat.:
    U11526m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
    Polyclonal Antibody for Human Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
    Cat.:
    P11526Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
    Monoclonal Antibody for Human Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
    Protein for Human Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein
    Protein for Human Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

    R&D Technical Data

    s

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    s
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Precision

    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤6.4%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤8.9%

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

    Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

    Intra-Assay CV: ≤3.9%

    Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

    Inter-Assay CV: ≤7.7%

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Recovery

    Recovery was determined by spiking various levels of HERP1 into serum and plasma .

    Sample Type

    Average(%)

    Recovery Range(%)

    Serum

    104

    95-107

    Plasma

    102

    96-105

     

     

     

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

    Recovery was determined by spiking various levels of ACE into serum and plasma .

    Sample Type

    Average(%)

    Recovery Range(%)

    Serum

    99

    91-103

    Plasma

    98

    93-106

     

     

     

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    Linearity

     

    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of HERP1and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    99-109%

    97-111%

    95-115%

    98-112%

    EDTA plasma(n=5)

    93-110%

    95-110%

    92-113%

    93-109%

    heparin plasma(n=5)

    97-108%

     

    94-112%

    96-108%

    96-107%

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

     

    The linearity of the kit was assayed by testing samples spiked with appropriate concentration of ACE and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.  

     

    Sample

    1:2

    1:4

    1:8

    1:16

    serum(n=5)

    92-105%

    90-101%

    95-105%

    92-109%

    EDTA plasma(n=5)

    89-95%

    93105%

    89-94%

    90-106%

    heparin plasma(n=5)

    93-104%

     

    94-110%

    101-111%

    91-110%

     

    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Herp, a new ubiquitin-like membrane protein induced by endoplasmic reticulum stress."
      Kokame K. , Agarwala K.L. , Kato H. , Miyata T.
      J. Biol. Chem.275:32846-32853(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);INDUCTION;SUBCELLULAR LOCATION;MEMBRANE TOPOLOGY
      tissue: Umbilical vein endothelial cell.
    2. 2.
      "Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1."
      Nomura N. , Miyajima N. , Sazuka T. , Tanaka A. , Kawarabayasi Y. , Sato S. , Nagase T. , Seki N. , Ishikawa K. , Tabata S.
      DNA Res.1:27-35(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
      tissue: Bone marrow.
    3. 3.
      Yu W. , Gibbs R.A.
      Submitted (1998-03) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      tissue: Brain.
    4. 4.
      "Identification of ERSE-II, a new cis-acting element responsible for the ATF6-dependent mammalian unfolded protein response."
      Kokame K. , Kato H. , Miyata T.
      J. Biol. Chem.276:9199-9205(2001) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA]
    5. 5.
      "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
      Submitted (2004-06) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1)
    6. 6.
      "The sequence and analysis of duplication-rich human chromosome 16."
      Martin J. , Han C. , Gordon L.A. , Terry A. , Prabhakar S. , She X. , Xie G. , Hellsten U. , Chan Y.M. , Altherr M. , Couronne O. , Aerts A. , Bajorek E. , Black S. , Blumer H. , Branscomb E. , Brown N.C. , Bruno W.J. , more...
      Nature432:988-994(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    7. 7.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3)
      tissue: Brain.
      tissue: Eye.
      tissue: Placenta.
      tissue: Testis.
    8. 8.
      "Endoplasmic reticulum stress-inducible protein, Herp, enhances presenilin-mediated generation of amyloid beta-protein."
      Sai X. , Kawamura Y. , Kokame K. , Yamaguchi H. , Shiraishi H. , Suzuki R. , Suzuki T. , Kawaichi M. , Miyata T. , Kitamura T. , De Strooper B. , Yanagisawa K. , Komano H.
      J. Biol. Chem.277:12915-12920(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH PSEN1 AND PSEN2
    9. 9.
      "The novel MMS-inducible gene Mif1/KIAA0025 is a target of the unfolded protein response pathway."
      van Laar T. , Schouten T. , Hoogervorst E. , van Eck M. , van der Eb A.J. , Terleth C.
      FEBS Lett.469:123-131(2000) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: CHARACTERIZATION
      tissue: Skin fibroblast.
    10. 10.
      "The ubiquitin-domain protein HERP forms a complex with components of the endoplasmic reticulum associated degradation pathway."
      Schulze A. , Standera S. , Buerger E. , Kikkert M. , van Voorden S. , Wiertz E. , Koning F. , Kloetzel P.-M. , Seeger M.
      J. Mol. Biol.354:1021-1027(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INTERACTION WITH SYVN1
    11. 11.
      "Luman/CREB3 induces transcription of the endoplasmic reticulum (ER) stress response protein Herp through an ER stress response element."
      Liang G. , Audas T.E. , Li Y. , Cockram G.P. , Dean J.D. , Martyn A.C. , Kokame K. , Lu R.
      Mol. Cell. Biol.26:7999-8010(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INDUCTION
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH UBXN6
    13. 13.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    15. 15.
      "Solution structure of the UBL-domain of HERP."
      RIKEN structural genomics initiative (RSGI)
      Submitted (2004-11) to the PDB data bank
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: STRUCTURE BY NMR OF 10-90
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