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Index > Protein center > Hm13(Gene name) > Mouse
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  • Hm13 (Gene name),
  • Minor histocompatibility antigen H13 (Protein name ),  HM13_MOUSE from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    Hm13(H13;Psl3);
    Protein name:
    Minor histocompatibility antigen H13;
    Alternative:
    Signal peptide peptidase;Presenilin-like protein 3;
    Organism:
    Mouse (Mus musculus). 
    General Annotation
    Sub Unit:
    Interacts with RNF139.
    Function:
    Catalyzes intramembrane proteolysis of some signal peptides after they have been cleaved from a preprotein, resulting in the release of the fragment from the ER membrane into the cytoplasm. Required to generate lymphocyte cell surface (HLA-E) epitopes derived from MHC class I signal peptides. Involved in the intramembrane cleavage of the integral membrane protein PSEN1 (By similarity). May play a role in graft rejection.
    Subcellular Location:
    Isoform 4 Cell membrane Multi-pass membrane protein
    Protein Attributes:
    Sequence length:
    378
    Sequence:
    50:
    MDSAVSDPHN | GSAEAGTPAN | GTTRPPSTPE | GIALAYGSLL | LMALLPIFFG | 
    100:
    ALRSVRCARG | KSSSDMPETI | TSRDAARFPI | IASCTLLGLY | LFFKIFSQEY | 
    150:
    INLLLSMYFF | VLGILALSHT | ISPFMNKFFP | ANFPNRQYQL | LFTQGSGENK | 
    200:
    EEIINYEFDT | KDLVCLGLSS | VVGVWYLLRK | HWIANNLFGL | AFSLNGVELL | 
    250:
    HLNNVSTGCI | LLGGLFIYDI | FWVFGTNVMV | TVAKSFEAPI | KLVFPQDLLE | 
    300:
    KGLEADNFAM | LGLGDIVIPG | IFIALLLRFD | ISLKKNTHTY | FYTSFAAYIF | 
    350:
    GLGLTIFIMH | IFKHAQPALL | YLVPACIGFP | VLVALAKGEV | AEMFSYEESN | 
    378:
    PKDPAAETES | KEESTEASAS | KRLEKKEK
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    UniGene:
    String:
    Pfam:
    KEGG:
    Uniprot:
     
    FOR
    ELISA Kit for Mouse Minor histocompatibility antigen H13
    ELISA Kit for Mouse Minor histocompatibility antigen H13
    CLIA Kit for Mouse Minor histocompatibility antigen H13
    CLIA Kit for Mouse Minor histocompatibility antigen H13
    Polyclonal Antibody for Mouse Minor histocompatibility antigen H13
    Polyclonal Antibody for Mouse Minor histocompatibility antigen H13
    Monoclonal Antibody for Mouse Minor histocompatibility antigen H13
    Monoclonal Antibody for Mouse Minor histocompatibility antigen H13
    Protein for Mouse Minor histocompatibility antigen H13
    Protein for Mouse Minor histocompatibility antigen H13

    R&D Technical Data
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Precision
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Recovery
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
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    Linearity
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    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.
    References
    1. 1.
      "Expression of the presenilin-like signal peptide peptidase (SPP) in mouse adult brain and during development."
      Urny J. , Hermans-Borgmeyer I. , Gercken G. , Chica Schaller H.
      Gene Expr. Patterns3:685-691(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);SUBCELLULAR LOCATION;TISSUE SPECIFICITY;DEVELOPMENTAL STAGE
      tissue: Placenta.
    2. 2.
      "Cell-surface expression of a new splice variant of the mouse signal peptide peptidase."
      Urny J. , Hermans-Borgmeyer I. , Schaller H.C.
      Biochim. Biophys. Acta1759:159-165(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4);SUBCELLULAR LOCATION;TISSUE SPECIFICITY
    3. 3.
      "Characterization of a new protein family with homology to presenilins."
      Irmler M. , Tomiuk S. , Korner M.R. , Hofmann K. , Conradt M.
      Submitted (2001-09) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1)
      strain: BALB/c.
    4. 4.
      "Genomic analysis of the H13 minor histocompatibility antigen gene."
      Brown A.C. , Roopenian D.C.
      Submitted (2002-02) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1);NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 63-344
      strain: 129P3/J.
    5. 5.
      "The transcriptional landscape of the mammalian genome."
      Carninci P. , Kasukawa T. , Katayama S. , Gough J. , Frith M.C. , Maeda N. , Oyama R. , Ravasi T. , Lenhard B. , Wells C. , Kodzius R. , Shimokawa K. , Bajic V.B. , Brenner S.E. , Batalov S. , Forrest A.R. , Zavolan M. , Davis M.J. , more...
      Science309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2)
      strain: C57BL/6J.
      tissue: Adipose tissue.
      tissue: Cerebellum.
      tissue: Embryo.
      tissue: Lung.
      tissue: Ovary.
      tissue: Pancreas.
      tissue: Thymus.
      tissue: Uterus.
    6. 6.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
      strain: C57BL/6J.
    7. 7.
      Mural R.J. , Adams M.D. , Myers E.W. , Smith H.O. , Venter J.C.
      Submitted (2005-07) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    8. 8.
      "Minors held by majors: the H13 minor histocompatibility locus defined as a peptide/MHC class I complex."
      Mendoza L.M. , Paz P. , Zuberi A. , Christianson G.J. , Roopenian D.C. , Shastri N.
      Immunity7:461-472(1997) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE OF 119-193 (ISOFORM 3)
      strain: BALB/c.
      strain: C57BL/10.
      strain: C57BL/6.
      strain: C57BL/6J.
      strain: LP/J.
      tissue: Thymic lymphoma.
    9. 9.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 203-378 (ISOFORMS 1/3)
      strain: FVB/N.
      tissue: Mammary gland.
    10. 10.
      "The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER."
      Stagg H.R. , Thomas M. , van den Boomen D. , Wiertz E.J. , Drabkin H.A. , Gemmill R.M. , Lehner P.J.
      J. Cell Biol.186:685-692(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RNF139
    11. 11.
      "How H13 histocompatibility peptides differing by a single methyl group and lacking conventional MHC binding anchor motifs determine self-nonself discrimination."
      Ostrov D.A. , Roden M.M. , Shi W. , Palmieri E. , Christianson G.J. , Mendoza L. , Villaflor G. , Tilley D. , Shastri N. , Grey H. , Almo S.C. , Roopenian D.C. , Nathenson S.G.
      J. Immunol.168:283-289(2002) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 169-177 IN COMPLEX WITH H2-D
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