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Index > Protein center > HMGCS1(Gene name) > Human
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  • HMGCS1 (Gene name),
  • Hydroxymethylglutaryl-CoA synthase, cytoplasmic (Protein name ),  HMCS1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Gene name:
    HMGCS1(HMGCS);
    Protein name:
    Hydroxymethylglutaryl-CoA synthase, cytoplasmic(HMG-CoA synthase);
    Alternative:
    3-hydroxy-3-methylglutaryl coenzyme A synthase;
    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    Function:
    This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase.
    Subcellular Location:
    Cytoplasm
    Protein Attributes:
    Sequence length:
    520
    Sequence:
    50:
    MPGSLPLNAE | ACWPKDVGIV | ALEIYFPSQY | VDQAELEKYD | GVDAGKYTIG | 
    100:
    LGQAKMGFCT | DREDINSLCM | TVVQNLMERN | NLSYDCIGRL | EVGTETIIDK | 
    150:
    SKSVKTNLMQ | LFEESGNTDI | EGIDTTNACY | GGTAAVFNAV | NWIESSSWDG | 
    200:
    RYALVVAGDI | AVYATGNARP | TGGVGAVALL | IGPNAPLIFE | RGLRGTHMQH | 
    250:
    AYDFYKPDML | SEYPIVDGKL | SIQCYLSALD | RCYSVYCKKI | HAQWQKEGND | 
    300:
    KDFTLNDFGF | MIFHSPYCKL | VQKSLARMLL | NDFLNDQNRD | KNSIYSGLEA | 
    350:
    FGDVKLEDTY | FDRDVEKAFM | KASSELFSQK | TKASLLVSNQ | NGNMYTSSVY | 
    400:
    GSLASVLAQY | SPQQLAGKRI | GVFSYGSGLA | ATLYSLKVTQ | DATPGSALDK | 
    450:
    ITASLCDLKS | RLDSRTGVAP | DVFAENMKLR | EDTHHLVNYI | PQGSIDSLFE | 
    500:
    GTWYLVRVDE | KHRRTYARRP | TPNDDTLDEG | VGLVHSNIAT | EHIPSPAKKV | 
    520:
    PRLPATAAEP | EAAVISNGEH | 
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
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    Related Databases
    MIM:
    KEGG:
    UniGene:
    SMR:
    Pfam:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human HMG-CoA synthase
    Cat.:
    E1759h
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    96T
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    ELISA Kit for Human HMG-CoA synthase
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    E1759m
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    Packing:
    96T
    ELISA Kit for Human HMG-CoA synthase
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    E1759c
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    96T
    ELISA Kit for Human HMG-CoA synthase
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    E1759r
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    Packing:
    96T
    CLIA Kit for Human HMG-CoA synthase
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    U1759m
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    MSDS:
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    Packing:
    96T
    CLIA Kit for Human HMG-CoA synthase
    Cat.:
    U1759h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human HMG-CoA synthase
    Cat.:
    U1759r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human HMG-CoA synthase
    Cat.:
    U1759c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human HMG-CoA synthase
    Cat.:
    P1759Rb-r
    Price:
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    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human HMG-CoA synthase
    Cat.:
    P1759Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human HMG-CoA synthase
    Polyclonal Antibody for Human HMG-CoA synthase
    Cat.:
    P1759Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Monoclonal Antibody for Human HMG-CoA synthase
    Monoclonal Antibody for Human HMG-CoA synthase
    Monoclonal Antibody for Human HMG-CoA synthase
    Monoclonal Antibody for Human HMG-CoA synthase
    Protein for Human HMG-CoA synthase
    Protein for Human HMG-CoA synthase
    Protein for Human HMG-CoA synthase
    Protein for Human HMG-CoA synthase

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    References
    1. 1.
      "Amplification and direct sequencing of a cDNA encoding human cytosolic 3-hydroxy-3-methylglutaryl-coenzyme A synthase."
      Russ A.P. , Ruzicka V. , Maerz W. , Appelhans H. , Gross W.
      Biochim. Biophys. Acta1132:329-331(1992) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
      tissue: Fibroblast.
    2. 2.
      "Human cytoplasmic 3-hydroxy-3-methylglutaryl coenzyme A synthase: expression, purification, and characterization of recombinant wild-type and Cys129 mutant enzymes."
      Rokosz L.L. , Boulton D.A. , Butkiewicz E.A. , Sanyal G. , Cueto M.A. , Lachance P.A. , Hermes J.D.
      Arch. Biochem. Biophys.312:1-13(1994) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];CHARACTERIZATION;MUTAGENESIS
      tissue: Fetal adrenal gland.
    3. 3.
      "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N. , Chen X. , Rolfs A. , Halleck A. , Hines L. , Eisenstein S. , Koundinya M. , Raphael J. , Moreira D. , Kelley T. , LaBaer J. , Lin Y. , Phelan M. , Farmer A.
      Submitted (2003-05) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    4. 4.
      "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T. , Suzuki Y. , Nishikawa T. , Otsuki T. , Sugiyama T. , Irie R. , Wakamatsu A. , Hayashi K. , Sato H. , Nagai K. , Kimura K. , Makita H. , Sekine M. , Obayashi M. , Nishi T. , Shibahara T. , Tanaka T. , Ishii S. , more...
      Nat. Genet.36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Placenta.
    5. 5.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    6. 6.
      "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
      tissue: Lung.
    7. 7.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-476 AND SER-495;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    8. 8.
      "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
      Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    9. 9.
      "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
      Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-495;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Leukemic T-cell.
    10. 10.
      "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
      Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-46 AND LYS-273;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    11. 11.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-495;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    13. 13.
      "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
      Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-4 AND SER-495;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
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