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Index > Protein center > HMOX1(Gene name) > Human
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  • HMOX1 (Gene name),
  • Heme oxygenase 1 (Protein name ),  HMOX1_HUMAN from NCBI database.
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  • General Annotation
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  • Antigen Annotation
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  • 3D
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  • Predicted Eptitope
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  • Vaild Sequence
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  • Related Databases
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  • Gene name:
    HMOX1(HO;HO1);
    Protein name:
    Heme oxygenase 1(HO-1);
    Alternative:

    Organism:
    Human (Homo sapiens). 
    General Annotation
    Sub Unit:
    N/A
    Function:
    Heme oxygenase cleaves the heme ring at the alpha methene bridge to form biliverdin. Biliverdin is subsequently converted to bilirubin by biliverdin reductase. Under physiological conditions, the activity of heme oxygenase is highest in the spleen, where senescent erythrocytes are sequestrated and destroyed.
    Subcellular Location:
    Microsome Endoplasmic reticulum
    Protein Attributes:
    Sequence length:
    288
    Sequence:
    50:
    MERPQPDSMP | QDLSEALKEA | TKEVHTQAEN | AEFMRNFQKG | QVTRDGFKLV | 
    100:
    MASLYHIYVA | LEEEIERNKE | SPVFAPVYFP | EELHRKAALE | QDLAFWYGPR | 
    150:
    WQEVIPYTPA | MQRYVKRLHE | VGRTEPELLV | AHAYTRYLGD | LSGGQVLKKI | 
    200:
    AQKALDLPSS | GEGLAFFTFP | NIASATKFKQ | LYRSRMNSLE | MTPAVRQRVI | 
    250:
    EEAKTAFLLN | IQLFEELQEL | LTHDTKDQSP | SRAPGLRQRA | SNKVQDSAPV | 
    288:
    ETPRGKPPLN | TRSQAPLLRW | VLTLSFLVAT | VAVGLYAM
    3D Structure:
    N/A
    Predicted Eptitope:
    Please Sign in.
    EIAab Sequence  Vaild Sequence:
    Please Sign in.
    Related Databases
    SMR:
    KEGG:
    Pfam:
    MIM:
    UniGene:
    String:
    Uniprot:
     
    FOR
    ELISA Kit for Human HO-1
    Cat.:
    E0584h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human HO-1
    Cat.:
    E0584m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human HO-1
    Cat.:
    E0584r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human HO-1
    Cat.:
    E0584b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human HO-1
    Cat.:
    E0584c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    ELISA Kit for Human HO-1
    Cat.:
    E0584p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human HO-1
    Cat.:
    U0584b
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human HO-1
    Cat.:
    U0584p
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    CLIA Kit for Human HO-1
    Cat.:
    U0584r
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human HO-1
    Cat.:
    U0584m
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human HO-1
    Cat.:
    U0584h
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Range:
    Please sign in first.
    CLIA Kit for Human HO-1
    Cat.:
    U0584c
    Price:
    Please sign in first.
    MSDS:
    Please sign in first.
    Packing:
    96T
    Polyclonal Antibody for Human HO-1
    Polyclonal Antibody for Human HO-1
    Polyclonal Antibody for Human HO-1
    Cat.:
    P0584Rb-m
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human HO-1
    Cat.:
    P0584Rb-h
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human HO-1
    Cat.:
    P0584Rb-r
    Price:
    Please sign in first.
    Packing:
    40ug/0.2ml
    Polyclonal Antibody for Human HO-1
    Monoclonal Antibody for Human HO-1
    Monoclonal Antibody for Human HO-1
    Monoclonal Antibody for Human HO-1
    Monoclonal Antibody for Human HO-1
    Monoclonal Antibody for Human HO-1
    Monoclonal Antibody for Human HO-1
    Protein for Human HO-1
    Protein for Human HO-1
    Protein for Human HO-1
    Cat.:
    R0584h
    Price:
    Please sign in first.
    Packing:
    1mg
    Purity:
    >90%
    Protein for Human HO-1
    Protein for Human HO-1
    Protein for Human HO-1

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    References
    1. 1.
      "Human heme oxygenase cDNA and induction of its mRNA by hemin."
      Yoshida T. , Biro P. , Cohen T. , Mueller R.M. , Shibahara S.
      Eur. J. Biochem.171:457-461(1988) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA]
    2. 2.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]
    3. 3.
      SeattleSNPs variation discovery resource
      Submitted (2003-11) to the EMBL/GenBank/DDBJ databases
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA];VARIANT HIS-7
    4. 4.
      "The DNA sequence of human chromosome 22."
      Dunham I. , Hunt A.R. , Collins J.E. , Bruskiewich R. , Beare D.M. , Clamp M. , Smink L.J. , Ainscough R. , Almeida J.P. , Babbage A.K. , Bagguley C. , Bailey J. , Barlow K.F. , Bates K.N. , Beasley O.P. , Bird C.P. , Blakey S.E. , Bridgeman A.M. , more...
      Nature402:489-495(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
    5. 5.
      "Heme oxygenase is the major 32-kDa stress protein induced in human skin fibroblasts by UVA radiation, hydrogen peroxide, and sodium arsenite."
      Keyse S.M. , Tyrrell R.M.
      Proc. Natl. Acad. Sci. U.S.A.86:99-103(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-103
      tissue: Foreskin.
    6. 6.
      "Structural organization of the human heme oxygenase gene and the function of its promoter."
      Shibahara S. , Sato M. , Muller R.M. , Yoshida T.
      Eur. J. Biochem.179:557-563(1989) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-7
    7. 7.
      "Oxidative stress causes enhanced endothelial cell injury in human heme oxygenase-1 deficiency."
      Yachie A. , Niida Y. , Wada T. , Igarashi N. , Kaneda H. , Toma T. , Ohta K. , Kasahara Y. , Koizumi S.
      J. Clin. Invest.103:129-135(1999) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INVOLVEMENT IN HMOX1D
    8. 8.
      "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
      Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    9. 9.
      "Mechanisms of cell protection by heme oxygenase-1."
      Gozzelino R. , Jeney V. , Soares M.P.
      Annu. Rev. Pharmacol. Toxicol.50:323-354(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: REVIEW ON ANTIAPOPTOTIC FUNCTION
    10. 10.
      "CXCR3-B can mediate growth-inhibitory signals in human renal cancer cells by down-regulating the expression of heme oxygenase-1."
      Datta D. , Banerjee P. , Gasser M. , Waaga-Gasser A.M. , Pal S.
      J. Biol. Chem.285:36842-36848(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: TISSUE SPECIFICITY
    11. 11.
      "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
      Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-229;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
      tissue: Cervix carcinoma.
    12. 12.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
    13. 13.
      "Endoplasmic reticulum anchored heme-oxygenase 1 faces the cytosol."
      Gottlieb Y. , Truman M. , Cohen L.A. , Leichtmann-Bardoogo Y. , Meyron-Holtz E.G.
      Haematologica97:1489-1493(2012) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: SUBCELLULAR LOCATION
    14. 14.
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.08 ANGSTROMS)
    15. 15.
      "Crystal structures of the ferric, ferrous, and ferrous-NO forms of the Asp140Ala mutant of human heme oxygenase-1: catalytic implications."
      Lad L. , Wang J. , Li H. , Friedman J. , Bhaskar B. , Ortiz de Montellano P.R. , Poulos T.L.
      J. Mol. Biol.330:527-538(2003) [PubMed] [Europe PMC] [Abstract]
      [15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (1.55 ANGSTROMS) OF 1-233 OF MUTANT ALA-140;HEME-BINDING SITES;MUTAGENESIS OF ASP-140
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