Gene name:
HNRNPU(HNRPU;SAFA;U21.1);
Protein name:
Heterogeneous nuclear ribonucleoprotein U(hnRNP U);
Alternative:
p120;Scaffold attachment factor A(SAF-A);pp120;
Organism:
Human (Homo sapiens).
General Annotation
Sub Unit:
Identified in the spliceosome C complex. Component of the coding region determinant (CRD)-mediated complex, composed of DHX9, HNRNPU, IGF2BP1, SYNCRIP and YBX1. Identified in a mRNP complex, at least composed of DHX9, DDX3X, ELAVL1, HNRNPU, IGF2BP1, ILF3, PABPC1, PCBP2, PTBP2, STAU1, STAU2, SYNCRIP and YBX1. Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with IGF2BP1 and ERBB4. Ligand for CR2.
Function:
Component of the CRD-mediated complex that promotes MYC mRNA stabilization. Binds to pre-mRNA. Has high affinity for scaffold-attached region (SAR) DNA. Binds to double- and single-stranded DNA and RNA.
Subcellular Location:
Nucleus
Cytoplasm
Cell surface
Localized in cytoplasmic mRNP granules containing untranslated mRNAs. Component of ribonucleosomes. Also found associated with the cell surface.
Protein Attributes:
50:
MSSSPVNVKK | LKVSELKEEL | KKRRLSDKGL | KAELMERLQA | ALDDEEAGGR |
100:
PAMEPGNGSL | DLGGDSAGRS | GAGLEQEAAA | GGDEEEEEEE | EEEEGISALD |
150:
GDQMELGEEN | GAAGAADSGP | MEEEEAASED | ENGDDQGFQE | GEDELGDEEE |
200:
GAGDENGHGE | QQPQPPATQQ | QQPQQQRGAA | KEAAGKSSGP | TSLFAVTVAP |
250:
PGARQGQQQA | GGKKKAEGGG | GGGRPGAPAA | GDGKTEQKGG | DKKRGVKRPR |
300:
EDHGRGYFEY | IEENKYSRAK | SPQPPVEEED | EHFDDTVVCL | DTYNCDLHFK |
350:
ISRDRLSASS | LTMESFAFLW | AGGRASYGVS | KGKVCFEMKV | TEKIPVRHLY |
400:
TKDIDIHEVR | IGWSLTTSGM | LLGEEEFSYG | YSLKGIKTCN | CETEDYGEKF |
450:
DENDVITCFA | NFESDEVELS | YAKNGQDLGV | AFKISKEVLA | GRPLFPHVLC |
500:
HNCAVEFNFG | QKEKPYFPIP | EEYTFIQNVP | LEDRVRGPKG | PEEKKDCEVV |
550:
MMIGLPGAGK | TTWVTKHAAE | NPGKYNILGT | NTIMDKMMVA | GFKKQMADTG |
600:
KLNTLLQRAP | QCLGKFIEIA | ARKKRNFILD | QTNVSAAAQR | RKMCLFAGFQ |
650:
RKAVVVCPKD | EDYKQRTQKK | AEVEGKDLPE | HAVLKMKGNF | TLPEVAECFD |
700:
EITYVELQKE | EAQKLLEQYK | EESKKALPPE | KKQNTGSKKS | NKNKSGKNQF |
750:
NRGGGHRGRG | GFNMRGGNFR | GGAPGNRGGY | NRRGNMPQRG | GGGGGSGGIG |
800:
YPYPRAPVFP | GRGSYSNRGN | YNRGGMPNRG | NYNQNFRGRG | NNRGYKNQSQ |
825:
GYNQWQQGQF | WGQKPWSQHY | HQGYY
Vaild Sequence:
Related Databases
Uniprot: